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    Associate Principal Scientist, Biology - San Francisco, United States - Atomwise

    Atomwise
    Atomwise San Francisco, United States

    1 day ago

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    Description
    [Full Time] Associate Principal Scientist, Biology at Atomwise (United States) | BEAMSTART Jobs

    Associate Principal Scientist, Biology

    Atomwise United States
    Date Posted
    20 Apr, 2023
    Work Location
    San Francisco, United States
    Salary Offered
    $164400 — $170000 yearly
    Job Type
    Full Time
    Experience Required
    6+ years
    Remote Work
    Yes
    Stock Options
    No
    Vacancies
    1 available
    Company Overview

    Atomwise is revolutionizing how drugs are discovered with AI.

    The Company invented the use of deep learning for structure-based drug discovery and is developing a pipeline of small-molecule drug candidates advancing into preclinical studies.

    The AtomNet technology has been used to unlock more undruggable targets than any other AI drug discovery platform. Atomwise is tackling over 600 unique disease targets across 775 collaborations spanning more than 250 partners around the world.

    The Atomwise portfolio of joint ventures and partnerships with leading pharmaceutical, agrochemical, and emerging biotechnology companies represents a collective deal value approaching $7 billion.

    To date, Atomwise has raised over $174 million from leading venture capital firms to advance its mission to

    make better medicines, faster.

    To support its mission, further its progress in enterprise building and leverage its robust discovery engine, Atomwise is building biology and pharmacology capabilities to fully leverage its small molecule AI expertise to advance molecules for clinical development.

    You will work closely with Atomwise interdisciplinary teams to provide guidance on pharmacology strategy, clinical indications of interest, and other aspects of drug development.

    Role Summary


    Atomwise is recruiting an experienced pharmacologist to support the organization's internal drug discovery portfolio into early-stage and late-stage development programs with a goal to design and oversee preclinical studies that will allow the robust evaluation of lead molecules and small molecule candidates.

    You will provide strategic and technical leadership to the teams supporting drug discovery projects from target discovery through IND-enabling studies.

    This role requires excellent communication skills, in-depth knowledge of

    in vitro

    pharmacology, and hands-on experience with biochemical and cellular assays.

    You will work effectively with an interdisciplinary team of computational and medicinal chemists, biologists, cheminformaticians, software engineers, CROs, and program managers to define, build, and optimize our discovery programs.

    Key Responsibilities

    Lead and collaborate with project teams to develop

    in vitro

    pharmacology strategies and support Atomwise preclinical discovery programs.

    Develop pharmacology criteria for the advancement of programs from hit identification to lead optimization including key milestones/decision points and timelines, identifying risks and mitigation strategies, and study planning and execution.

    Direct the selection, validation, and analysis of quantitative biophysical, biochemical, and cellular assays to evaluate binding and function of Atomwise molecules across diverse target classes and therapeutic areas.

    Oversee the design and execution of novel

    in vitro , including assay development/validation and quality control, through management of CRO partners.
    Participate in the evaluation and selection of new Atomwise targets across a range of target types and therapeutic indications.
    Required Qualifications

    Ph.
    D. in biochemistry or pharmacology plus 6+ years of relevant industry experience.
    Extensive hands-on experience building

    in vitro

    pharmacology assays (biochemical, biophysical, and cellular) in a drug discovery setting. Expertise developing quantitative plate-based assays using lab automation/liquid handlers.
    Expertise building

    in vitro

    pharmacology critical paths to support preclinical development for early discovery programs.
    Demonstrated success in the management of CROs, including evaluation/selection, setting up processes, and data management.

    Experience collaborating with medicinal chemists and project teams to build effective critical paths to drive structure-activity relationships (SAR) and selection of high-quality chemical series and development candidates.

    Demonstrated track record of clear communication, working with a multidisciplinary team, mentoring, and developing talent.
    Compensation & benefits

    Competitive salary, commensurate with experience
    Stock compensation plan – you'll be an Atomwise co-owner
    Platinum health, dental, and vision benefits
    401k with 4% match
    Funding for professional development and conference attendance
    Flexible work schedule
    Generous parental leave
    High performance culture
    Great colleagues
    Atomwise is an equal opportunity employer and strives to foster an inclusive workplace.

    Our mission is to develop better medicines faster, and we know that we need a diverse team to develop medicines that serve diverse populations.

    Accordingly, Atomwise does not make any employment decisions (including but not limited to, hiring, compensation, and promotions) on the basis of race, religion, color, national origin, gender, gender identity, sexual orientation, age, veteran status, disability status, or any other characteristics protected by applicable federal, state, and local law.

    We strongly encourage people of diverse backgrounds and perspectives to apply.
    *Pay range for this role is between $164,400- $170,000*About Atomwise

    Artificial intelligence for drug discovery.


    Company Size:
    People


    Year Founded:
    Not Specified


    Country:
    United States


    Company Status:
    Actively Hiring

    Looking for Partners

    Looking for Clients

    Raising Funds

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