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Postdoctoral Fellow-Arthroplasty Research Lab - New York, United States - Hospital for Special Surgery
Description
OverviewHow you move is why we're here. Now more than ever.
Get back to what you need and love to do.
The possibilities are endless...
Now more than ever, our guiding principles are helping us in our search for exceptional talent - candidates who align with our unique workplace culture and who want to maximize
the abundant opportunities for growth and success.
If this describes you then let's talk
HSS is consistently among the top-ranked hospitals for orthopedics and rheumatology by U.S. News & World Report.
As a recipient of the Magnet Award for Nursing Excellence, HSS was the first hospital in New York City to receive the distinguished designation.
Whether you are early in your career or an expert in your field, you will find HSS an innovative, supportive and inclusive environment.
Working with colleagues who love what they do and are deeply committed to our Mission, you too can be part of our transformation across the enterprise.
Bostrom Lab
Full-Time
Position Overview:
Postdoctoral Fellow position is available in the Arthroplasty Research Lab of Dr.
Mathias Bostrom at Hospital for Special Surgery Research Institute (HSSRI), to study the role of immune cells in successful and failed osseointegration.
Using a set of mouse implant osseointegration models developed by Dr.Xu Yang of the Arthroplasty Research Lab, we have recently demonstrated that LepR+ cells are the origin of peri-implant fibroblasts.
The paper reporting this finding has been accepted by Nature Biomedical Engineering. We will now use these models to study the interactions between immune cells and skeletal stem/progenitor cells after implantation.A special focus will be put on the mechanism and consequence of the formation of fibrosis tissue around implant during failed osseointegration.
Human macrophages or skeletal stem/progenitors from bone marrow or periprosthetic tissue of patients receiving primary or revision joint replacement surgeries will also be used to direct the design of animal models or confirm the findings from animal models.
Dr. Xu Yang is also collaborating with Dr.Lionel Ivashkiv, a bone immunologist, at HSSRI on a NIH R01 grant to investigate the inflammatory and bone marrow responses that drive osteoclastogenesis, and the feedback mechanisms that suppress the adaptive immune response to periprosthetic joint infection.
The position requires a Ph.D.
in Immunology or Molecular Biology, who has direct experience working with immune cells using advanced cellular, molecular, and genomic techniques.
This position combines in vivo research with molecular and cellular biology.For in vivo work, the candidate will be capable of assisting animal surgeries and have experience with isolating proteins and nucleic acids from mouse bone and clinical samples from patients receiving joint replacements.
For cellular and molecular studies, the candidate will also have experience with flowcytometry, immunofluorescence, cell culture, RT-PCR, and RNA-seq.The candidate is expected to have one or more high quality first author publications on immunology or mouse models of inflammation disease or both.
The candidate should be highly motivated and productive and interested in a career in research.Expertise in mouse models for wound healing and/or in working with immune cells in skeletal system would be a plus.
The postdoctoral fellow will report directly to Dr.Xu Yang to discuss the experimental plan and research direction in the area of interest and attend the weekly lab meeting with Dr.
Bostrom and Dr. Ivashkiv.Major duties and responsibilities
Minimum Job Requirements
#LI-Onsite
Pay Range - Minimum
USD $50,000.00/Yr.
Pay Range - Maximum
USD $60,000.00/Yr.
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