Jobs
>
Cambridge

    Computational Peptide Designer/Engineer - Cambridge, MA, United States - Fog pharma

    Fog pharma
    Fog pharma Cambridge, MA, United States

    2 weeks ago

    Default job background
    Description


    Why Join Us? FogPharma is a biopharmaceutical company pioneering the discovery and development of Helicon therapeutics, which are peptides capable of efficient cell entry and modulation of both protein-protein and protein-DNA interactions.

    Through Helicon therapeutics, FogPharma is poised to revolutionize the medical possibilities for patients by precisely drugging intracellular targets long understood to be significant drivers of disease but never before drugged due to the limitations of existing drug modalities to act within the cell.

    FOG-001, the company's first-in-class TCF-blocking β-catenin inhibitor, is being evaluated in a Phase 1/2 study for patients with advanced solid tumors, including colorectal cancer.

    FogPharma is fully leveraging the unprecedented potential Helicons present by deploying proprietary, custom-built machine learning and computational methods as part of its discovery and development process.

    FogPharma has raised more than $500 million to date from leading life sciences investors. FogPharma is headquartered in Cambridge, Mass.

    What's the opportunity?This position is a senior computational peptide design role reporting to the VP of Data Science, head of Computational Drug Discovery at Fog.

    We are seeking highly talented and motivated people to contribute to the development of the Computational Drug Discovery group, a strategic function in Data Science that is part of Fog's platform discovery engine for HeliconTM stapled-peptide drugs.

    The skill sets of the group includes state-of-the-art machine learning/generative AI, molecular modeling, cheminformatics, structural sciences and data science towards the discovery and development of HeliconTM stapled-peptide drugs.

    You'll be part of a data science team that is a central pillar of FogPharma's innovative discovery platform and pipelines targeting "undruggable" genes of major therapeutic interest to patients.

    Our data science team is an integrated team ranging from computational biology, bioinformatics, computational drug discovery, research informatics and data engineering.

    We work at the interface of chemistry, biology, clinical and computational sciences, and are responsible for all aspects of data science from building the discovery pipeline to supporting and developing our discovery platform.

    ResponsibilitiesProvide leadership and computational expertise towards, but not limited to, targeted screening library designs, hit-to-lead progression using multi-objective optimization, initiating new projects, new drug-target assessments and advancing drug-pipeline projects towards the clinic.

    Identify, implement, or apply 3D modeling techniques for sampling HeliconTM peptide conformations in presence of a target and in different physiological environments.

    Analyze and derive 3D peptide-structure relationships.

    Exemplify scientific leadership by partnering across functions and working within a team of talented and passionate scientists to discover drugs.

    Interface with CROs or external partners.

    What you'll need to be successfulPhD in Computational Biology, Computational Chemistry, Protein Engineering, Chemistry, Biophysics, Macromolecular sciences or related scientific field with 8+ years of experience in computational rational drug design (1-3 years industry).Demonstrated experience with peptide design or protein engineering including affinity maturation and a good understanding of peptide structure-property relationships (e.g.

    helicity and amphiphilicity metrics, cell penetration).Demonstrated mastery of modern computational chemistry including, but not limited to, peptide folding and docking, structure-based design (receptor and ligand-based), scaffold hopping, docking and conformational analysis.

    Expertise with active learning methods/approaches or similar for virtual screening.
    Expertise in one or more peptide modeling environments and methods (e.g. ICM, Rosetta, enhanced sampling MD, Monte Carlo) and general modeling environments.
    Expertise with 3D biomolecular modeling that incorporates constraints from NMR, CryoEM or other structural, biochemical data.
    Demonstrated understanding of critical assessment of molecule-property data and predictive model quality.
    Demonstrated understanding of experiments behind the data that can be translated to computational analysis.
    Experience with command line modeling applications. Familiarity with HPC workflow tools (e.g. Aiida) is a plus.
    Experience with enterprise research informatics systems such as Dotmatics, SQL databases and chemical and biological data warehouses.
    Experience with virtual screening and familiarity with cloud computing environments (e.g. Azure or AWS).An understanding of modern drug discovery including, but not limited to, medicinal chemistry, multi-parametric optimization, molecular recognition principles, and the ability to adapt and translate these principles to stapled peptides.

    Excellent communication, collaboration and scientific leadership skills within and across functions that contribute to and inspire a vibrant community of drug hunters.

    Familiarity with cheminformatics techniques is a plus.
    Demonstrated experience in leading teams (technical or drug-discovery focused) and the potential or experience in managing direct reports.
    Strong scientific programming skills (Python) in a Linux environment.
    As an equal opportunity employer, Fog values diversity and welcomes applicants of all backgrounds and experiences.

    All qualified applicants will receive consideration for employment without discrimination on the basis of race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability, or any other factors prohibited by law.

  • USA Tech Recruitment

    Machine Design Engineer

    4 weeks ago

    USA Tech Recruitment Cambridge, United States

    Machine Design Engineer · Job Description · The Senior Machine Design Engineer will be a member of the Advanced Manufacturing Team focused on developing the next generation high volume manufacturing processes that will connect a revolutionary product to the high growth energy sto ...

  • Strativ Group

    Mechanical Design Engineer

    5 days ago

    Strativ Group Cambridge, United States

    Mechanical Engineer (2-5 years exp.) · $100-$120K + Equity & Benefits · Cambridge, MA (Hybrid) · Want to be involved in designing the next generation of highly complex manufacturing equipment? · We are partnered with a world leading energy storage business that offer a revolution ...

  • MIT

    Facility Design and Equipment Engineer

    3 weeks ago

    MIT Cambridge, United States Full time

    Job Description · FACILITY DESIGN AND EQUIPMENT ENGINEER , , to maintain the environmental conditions, utilities, support systems, and logistics of the facility. Will install research equipment, including metrology instruments, semiconductor fabrication tools, abatement, safety ...

  • USA Tech Recruitment

    Senior Machine Design Engineer

    1 week ago

    USA Tech Recruitment Cambridge, United States

    Senior Machine Design Engineer · European Recruitment are working closely with an exciting battery company, based in Cambridge, who are looking for a talented Senior Machine Design Engineer to join their team. · In this role you will work within the Advanced Manufacturing Team fo ...

  • USA Tech Recruitment

    Senior Battery Design Engineer

    1 day ago

    USA Tech Recruitment Cambridge, United States

    Senior Battery Design Engineer · USA Tech Recruitment are working closely with an exciting battery company, based in Cambridge, who are looking for a talented SeniorBattery Design Engineer to join their team. · In this role you will work within the Product Development team to s ...

  • USA Tech Recruitment

    Senior Battery Design Engineer

    1 week ago

    USA Tech Recruitment Cambridge, United States

    Senior Battery Design Engineer · European Recruitment are working closely with an exciting battery company, based in Cambridge, who are looking for a talented Senior Battery Design Engineer to join their team. · In this role you will work within the Product Development team to su ...

  • European Recruitment

    Senior Battery Design Engineer

    5 days ago

    European Recruitment Cambridge, United States

    Senior Battery Design Engineer - Mechanical Cell Design · Are you interested in joining a dynamic team at a cutting-edge lithium-ion technology company in Boston? · Do you have a passion for Mechanical Engineering and want to contribute to innovative projects within a diverse and ...

  • USA Tech Recruitment

    Senior Machine Design Engineer

    1 week ago

    USA Tech Recruitment Cambridge, United States

    Senior Machine Design Engineer - CAD design / Battery Manufacturing / SolidWorks / ANSI · Are you passionate about next-gen cell technology? · Have 20+ years CAD Design Experience? · Have solid knowledge of various welding technologies, specifically, laser welding and ultrasonic ...

  • 24M Technologies

    Machine Design Engineer

    2 weeks ago

    24M Technologies Cambridge, Massachusetts, United States Permanent

    Job Description · The Machine Design Engineer will be a member of the Advanced Manufacturing Team focused on developing the next generation high volume manufacturing processes that will connect 24M's revolutionary product to the high growth energy storage market. The team member ...

  • SMMA

    HVAC Design Engineer

    20 hours ago

    SMMA Cambridge, United States

    Job Description · Job DescriptionSMMA has an opportunity for a Mechanical Engineer with 5+ years of experience. This position offers the ability to lead a range of multiple design project types and requires a good balance of leadership, technical, communication, and organizationa ...

  • HyperLight

    Photonic Design Engineer

    1 week ago

    HyperLight Cambridge, United States

    Photonic Design Engineer · HyperLight is a venture-backed startup spun off from Harvard University in 2018 based on discoveries that enabled thin-film lithium niobate (TFLN) photonics. Our photonic integrated circuits offer exceptional performance unmatched by other materials an ...

  • Apple

    Physical Design Engineer

    2 weeks ago

    Apple Cambridge, United States

    Summary · Posted: May 9, 2024 · Weekly Hours: · 40 · Role Number: · At Apple we work every single day to craft products that enrich people's lives. Do you love working on challenges that no one has solved yet? Do you like changing the game? We have an opportunity for a forwa ...

  • 24M Technologies

    Machine Design Engineer

    1 week ago

    24M Technologies Cambridge, United States

    Job Description · Job DescriptionCompany Description · 24M Technologies answers the world's need for affordable energy storage by enabling a new, more cost-effective solution — SemiSolidTM lithium-ion technology. Our breakthrough manufacturing platform provides for low-cost, high ...

  • Jobot

    Design Engineer

    3 weeks ago

    Jobot Watertown, United States

    Job Description · Job DescriptionApplication Engineer - (Responsive) · This Jobot Job is hosted by: David Six · Are you a fit? Easy Apply now by clicking the "Apply Now" buttonand sending us your resume. · Salary: $80,000 - $110,000 per year · A bit about us: · We are seeking a d ...

  • Commonwealth of Virginia

    Engineer Senior Roadway Design

    2 weeks ago

    Commonwealth of Virginia Suffolk, United States

    Job Duties · Core responsibilities for job & position · Responsible Charge Engineer · Fulfill duties as responsible charge engineer in compliance with policies, procedures and the Code of Virginia. · Policies and Procedures · Assist in the development of policies, procedures a ...

  • AHA Consulting Engineers, Inc.

    Designer (Electrical Engineering)

    1 day ago

    AHA Consulting Engineers, Inc. Boston, United States

    Job Description · Job DescriptionBackground · Over the past 33 years, AHA Consulting Engineers has worked successfully with owners, operators, Fortune 500 companies, Ivy League schools, top real estate developers, and award-winning architects. Our clients have relied on our passi ...

  • Pure Lithium Corporation

    Senior Mechanical Design Engineer

    3 weeks ago

    Pure Lithium Corporation Boston, United States

    Job Description: · We are seeking a highly experienced and innovative Senior Mechanical Design Engineer to join our team. The ideal candidate will be responsible for leading design projects in a team, providing technical expertise, and driving innovation in product development. T ...

  • BRIOHEALTH SOLUTIONS INC

    Design Quality Engineer

    2 days ago

    BRIOHEALTH SOLUTIONS INC Boston, United States

    Job Description · Job DescriptionThe Design Quality Engineer role is an exempt level position with responsibilities for supporting QA compliance activities for an active implantable medical device. As a Design Quality Engineer, you will play a crucial role in ensuring the quality ...

  • Nanobiosym

    Engineer: Sr. Electrical Design Engineer

    5 days ago

    Nanobiosym Cambridge, United States

    Job Description · Job DescriptionNanobiosym is an innovative nanotechnology Company in Cambridge, MA, that is developing advanced detectiontechnology to address a broad range of diseases. Nanobiosym was founded by an MIT/Harvard alum to work at the interface of physics, nanotechn ...

  • FootBridge

    Mechanical Design Engineering

    2 weeks ago

    FootBridge Boston, MA, United States

    Title: Senior Mechanical Engineer · Reports to: Lead Mechanical Engineer · Our client, a national engineering firm, is searching for a Senior Mechanical Engineer for their Boston office. This permanent position requires 4 days onsite in Boston, working with a collaborative, fun l ...