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Preclinical Development Manager
3 weeks ago
AOP Health Oklahoma City, United States Full timeAOP Health is the European pioneer for integrated therapies for rare diseases and in critical care. To enhance our team in Vienna we are looking for a: · Preclinical Development Manager (f/m/d) · Start: as of now · What Your Day To Day Will Look Like · You elaborate analytical m ...
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Chief Scientific Officer
10 hours ago
Myro Therapeutics, Inc. Oklahoma City, United States· Chief Scientific Officer · About Us · Myrobalan Therapeutics is a biotechnology company headquartered in Medford, Massachusetts, with a focus on developing oral neurorestorative therapies aimed at reversing key pathologies underlying brain dysfunctions and CNS conditions. We ...
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Chief Scientific Officer
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American Society Of Gene & Cell Therapy Oklahoma City, United StatesKelonia Therapeutics · is seeking a strategic, highly accomplished scientist and enterprise leader, with a track record of translating science into medicines, to join the team as Chief Scientific Officer. The ideal candidate will have the following mix of personal and profession ...
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Marketing Manager
3 weeks ago
Proclinical Staffing Oklahoma City, United StatesScientific Marketing Manager · Position Summary: · Our client, an innovative biotech, is looking for a Marketing Manager to spearhead the marketing team's daily operations, orchestrating the execution of marketing strategies. This is an opportunity to join a fantastic company wor ...
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Principal Scientist
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Entactbio Oklahoma City, United StatesPrincipal Scientist Medicinal Chemistry · Location: Watertown, MA · About Us: Entact Bio is a preclinical stage biotechnology company developing a new class of drugs that enhance the function of beneficial proteins. Launched by a founding team deeply rooted in deubiquitinase (D ...
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Customer Experience
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Ichgcp Oklahoma City, United States**Customer Experience (CX) Analyst** · **Charles River Laboratories International Inc (CRL)** · ****Wilmington, MA, US, 01887**** · Customer Experience (CX) Analyst Req ID #: 92535 Location: · Wilmington, MA, US, 01887 At Charles River, we are passionate about improving the quali ...
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Director/Sr. Director Clinical Operations
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Klein Hersh Oklahoma City, United StatesOur client is developing novel therapeutics designed to improve immune cell trafficking including the ability for T-cells to track and destroy cancer cells. They are committed to advancing the field of cancer immunotherapy and immune disorders through innovation and investment in ...
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Senior Director, Head of Product Sciences
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Affini-T Therapeutics Inc. Oklahoma City, United StatesAbout Affini-T Therapeutics · Affini-T Therapeutics is a biotechnology company focused on targeting oncogenic driver mutations with a "best-in-class" TCR therapy platform. Our innovative method of discovering high affinity TCRs specific to oncogenic driver mutations is used to de ...
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Associate Director/Director, DMPK
3 weeks ago
Apex Systems Oklahoma City, United StatesAssociate Director/Director, DMPK · Location: Watertown MA (Onsite) · Science/Focus: · Immunological Diseases · Job Overview: · This job requires partnering with various project teams, setting DMPK strategy, and driving execution of projects in the pharmaceutical industry, uti ...
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IT Engineer
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Chineseantibody Oklahoma City, United StatesACROBiosystems is a worldwide leader in developing and manufacturing recombinant proteins and critical reagents/assays to support drug development and clinical applications from target discovery and validation, candidate drug screening and optimization, CMC development, preclinic ...
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Executive Director, DMPK
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Nimbus Therapeutics Oklahoma City, United StatesNimbus has an outstanding opportunity for an exceptional Executive Director, DMPK to join our team. This role will serve as the function head, applying subject matter expertise in absorption, distribution, metabolism, and excretion (ADME), pharmacokinetics, and pharmacodynamics, ...
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Clarivate Oklahoma City, United StatesClarivate is a leading global provider of transformative intelligence. We offer enriched data, insights & analytics, workflow solutions and expert services in the areas of Academia & Government, Intellectual Property and Life Sciences & Healthcare. Our connected data, deep expert ...
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Chief Scientific Officer
3 days ago
Myro Therapeutics, Inc. Oklahoma City, United StatesChief Scientific Officer · About Us · Myrobalan Therapeutics is a biotechnology company headquartered in Medford, Massachusetts, with a focus on developing oral neurorestorative therapies aimed at reversing key pathologies underlying brain dysfunctions and CNS conditions. We appl ...
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Senior Manager, GCP Quality Assurance
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Vertex Ventures HC Oklahoma City, United StatesBicycle Therapeutics (NASDAQ: BCYC) is a clinical-stage biopharmaceutical company developing a novel class of medicines. Our pipeline includes Bicycle Toxin Conjugates as well as fully synthetic Bicycle systemic immune cell agonists and Bicycle tumor-targeted immune cell agonists ...
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Clinical Project Manager
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Genfit SA Oklahoma City, United StatesGENFIT is a late-stage biopharmaceutical company dedicated to improving the lives of patients with rare and severe liver diseases characterized by high unmet medical needs. GENFIT is a pioneer in liver disease research and development with a rich history and strong scientific her ...
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Vice President of Children's Clinical Services
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Kennedy-Donovan Center Oklahoma City, United StatesVice President of Early Intervention & Therapy · 4 days ago · Be among the first 25 applicants · Are you looking for an organization that allows flexibility in your work schedule? · At KDC we are on a mission to empower and support all people to meet their full potential in a ...
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Principal Scientist/ Associate Director
3 days ago
Entactbio Oklahoma City, United StatesPrincipal Scientist/ Associate Director – Proteomics · Location: Watertown, MA · About Us : Entact Bio is a preclinical stage biotechnology company developing a new class of drugs that enhance the function of beneficial proteins. Launched by a founding team deeply rooted in deub ...
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Principal Scientist, Translational Modeling
3 days ago
Novartis Farmacéutica Oklahoma City, United StatesPrincipal Scientist, Translational Modeling & Simulation · Job ID · 394914BR · Mar 22, 2024 · USA · About the Role · The position is located in Cambridge, MA and will not have the ability to be located remotely. · #LI-Hybrid · About the role: · We are seeking an experienced ...
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ACIP Oklahoma City, United StatesNanobiotix – a brief history · Est. 2003, Nanobiotix is a clinical-stage biotechnology company focused on developing first-in- · class product candidates that use proprietary nanotechnology to transform cancer treatment. · Headquartered in Paris (c.70 staff) and with a US affilia ...
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Principal Scientist
3 days ago
Entactbio Oklahoma City, United StatesPrincipal Scientist – Medicinal Chemistry · Location: Watertown, MA · About Us: Entact Bio is a preclinical stage biotechnology company developing a new class of drugs that enhance the function of beneficial proteins. Launched by a founding team deeply rooted in deubiquitinase ( ...
Associate Director, Translational Toxicology, Preclinical Development - Oklahoma City, United States - Wave Life Sciences
Description
Wave Life Sciences is a biotechnology company focused on unlocking the broad potential of RNA medicines to transform human health.
Our RNA medicines platform, PRISM, combines multiple modalities, chemistry innovation and deep insights in human genetics to deliver scientific breakthroughs that treat both rare and prevalent disorders.
Our toolkit of RNA-targeting modalities includes editing, splicing, RNA interference and antisense silencing, providing us with unmatched capabilities for designing and sustainably delivering candidates that optimally address disease biology.
Our diversified pipeline includes clinical programs in Duchenne muscular dystrophy, Alpha-1 antitrypsin deficiency and Huntington's disease, as well as a preclinical program in obesity.
Driven by the calling to "Reimagine Possible", we are leading the charge toward a world in which human potential is no longer hindered by the burden of disease.
Description:
Wave Life Sciences is seeking a highly motivated individual to join the Preclinical and Clinical Development Sciences team in Lexington, Massachusetts.
The candidate will be expected to provide scientific expertise and leadership across the Discovery and Development portfolio by contributing to the safety assessment of novel therapeutic oligonucleotides intended for the treatment of rare diseases.
The candidate should possess an in-depth understanding of safety pharmacology, investigative and regulatory toxicology, and have experience designing and critically evaluating results of exploratory and GLP-compliant toxicology studies.
Previous experience in authoring and reviewing nonclinical regulatory documents as well as interactions with regulatory authorities is required as is a background in the safety assessment of drugs intended to treat diseases of the hepatic, kidney, muscular and central nervous systems.
Experience:
DVM/PhD or PhD in biology, toxicology or related field, Board certification in toxicology is highly desirable
Relevant experience (7+ years) in preclinical safety assessment of novel therapeutic entities
Experience with regulatory submissions and responses
Responsibilities:
This position will be part of the Preclinical and Clinical Development Sciences (PCDS) team supporting development as a primary representative of PCDS on Program Teams.
Provide risk assessment and de-risking strategies for discovery programs
Design preclinical strategies for Discovery and Development candidate molecules
Design toxicity studies:
coordinate with Preclinical Outsourcing for placement and monitoring of the studies as well as the Bioanalytical and DMPK groups regarding integration of bioanalysis and toxicokinetic aspects into these studies to ensure on-time delivery of key data and study reports
Work with Platform Discovery Sciences, Translational Medicine and program teams to utilize and interpret animal models of diseases for efficacy/tolerability assessment and PK/PD evaluation
Lead the development of early hypothesis-driven investigation into mechanisms of toxicity for the proactive management of potential safety liabilities and communication of impact to teams
Provide strategic guidance to project teams and senior management including evaluation of conclusions and potential impact of toxicology results on program and clinical/regulatory strategy
Lead issue-resolution teams, driving the science for investigative and discovery toxicology as needed
Provide leadership as a key member of the Preclinical Development Leadership Team with opportunities for continual organizational advancement
Key Skills:
Knowledge of GLP compliance and relevant ICH & FDA guidance documents
Outstanding interpersonal skills and verbal and written communication skills
Ability to work effectively both independently and collaboratively in a dynamic team-oriented environment
Ability to oversee CRO interface, as appropriate, to deliver high quality, cost-effective, and timely safety assessment
Ability to collaborate with colleagues, internally and externally, to execute on the appropriate studies to support selection of therapeutic targets, and the identification and development of new drug candidates
Ability to travel to monitor out-sourced studies
Outstanding organizational skills/ability to prioritize and deliver in timely fashion
Wave Life Sciences provides equal employment opportunities (EEO) to all employees and applicants for employment without regard to race, color, religion, sex, national origin, age, disability or genetics.
In addition to federal law requirements, Wave Life Sciences complies with applicable state and local laws governing nondiscrimination in employment in every location in which the company has facilities.
This policy applies to all terms and conditions of employment, including recruiting, hiring, placement, promotion, termination, layoff, recall, transfer, leaves of absence, compensation and training.
Wave Life Sciences expressly prohibits any form of workplace harassment based on race, color, religion, gender, sexual orientation, gender identity or expression, national origin, age, genetic information, disability, or veteran status.
Improper interference with the ability of Wave Life Sciences' employees to perform their job duties may result in discipline up to and including discharge.
We value our relationships with professional recruitment firms.To protect the interests of all parties, and given the large volume of inquiries received from third-party placement agencies, we are not able to respond to all agency inquiries.
We do not accept unsolicited resumes from any source other than directly from candidates for current or future positions.Submission of unsolicited resumes in advance of a signed agreement between our company and a placement agency does not create an implied obligation and, if an unsolicited candidate represented by a placement agency is hired, we are not obligated to pay a fee.
Only approved recruitment firms will be allowed to provide services to Wave Life Sciences.#J-18808-Ljbffr
Associate Director, Translational Toxicology, Preclinical Development professionals in Oklahoma City
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Maria Collado Rivera
Bilingual (Spanish) Human Resources