Jobs
>
Cleveland

    Research Assistant 2 - Cleveland, United States - Case Western Reserve University

    Case Western Reserve University
    Case Western Reserve University Cleveland, United States

    1 week ago

    Default job background
    Description
    Job Description


    POSITION OBJECTIVE


    Working under general supervision, the Research Assistant 2 will plan and carry out research projects that contribute to the overall objective of the lab, which is to better understand the immune microenvironment in brain tumors, identify potential new strategies to make immunotherapy more effective for these patients, select lead strategies through testing in preclinical models, and translate lead strategies into clinical trials.

    This is a key position within the lab and will be responsible for the planning and execution of experiments in close collaboration with the principal investigator.

    The lab works closely together with other principal investigators in Pathology and the School of Medicine, including collaborations with a multidisciplinary team of biologists, chemists, computational scientists, surgeons, pathologists, and oncologists.

    This position will work with primary patient specimens.


    ESSENTIAL FUNCTIONS:

    • Plan and carry out accessioning projects in accordance with general regulatory requirements. Perform biosafety level 2 (BSL2) cell culture techniques with primary human cells and maintain organoid cultures derived from primary patient samples, ensuring optimal growth conditions and monitoring for health and proliferation. Prepare cells, organoids, and patient specimens for single cell sequencing. Prepare organoids and patient specimens for spatial transcriptomic methods. Prepare DNA/RNA libraries for genomic sequencing, following protocols for quality control and ensuring the accurate representation of samples. (40%)
    • Conduct a series of experiments to supply scientific information as part of a larger project. Prepare, evaluate samples in coordination with relevant lab staff. Conduct multiplex immunofluorescent staining on cell and tissue samples to visualize specific proteins of interest. Prepare DNA/RNA libraries for genomic sequencing, following protocols for quality control and ensuring the accurate representation of samples. Operate microscopy equipment for imaging of stained samples, ensuring high-quality capture of fluorescence signals. Perform flow cytometry experiments to analyze cell populations within samples, including staining, running samples through flow cytometers, and performing basic data analysis. (30%)
    • May assist in developing improved techniques, projection methods or procedures. Coordinate and facilitate the transfer of research samples between the university and other institutions ensuring all applicable policies are adhered to. (10%)
    • Collect and analyze clinical data (test requisitions) and record keeping support with high level data entry and by implementing quality data controls. Coordinate the collection, processing, and storage of clinical samples from collaborators or clinical partners, adhering to ethical guidelines and ensuring sample integrity. Maintain detailed experimental records, including methods, results, and observations, in electronic lab notebooks and electronic databases. Contribute to the preparation of figures, tables, and sections of manuscripts and reports under the guidance of senior lab members. (10%)
    • Oversee inventory. Maintain certain equipment facilities. Assist in maintaining laboratory equipment and inventory, including reagent preparation, sterilization of equipment, and ordering supplies as needed. Ensure a clean, organized, and safe working environment in compliance with institutional safety protocols. Train new personnel with common lab tasks and orientation. (10%)

    NONESSENTIAL FUNCTIONS
    Perform other duties as assigned. (<1%)

    CONTACTS.

    Department:
    Almost daily contact with supervisor, either in person or through electronic communications to discuss research plans and results. Work with clinical fellows, and postdoctoral employees to exchange information. Regular contact (several times a week) with clinical staff, including surgeons, oncologists, pathologists, clinical research coordinators, and surgical staff.

    University:
    Occasional contact with members of other departments, clinical staff, and administrators to share/support research activities.

    External:
    Limited contact with vendors to exchange information necessary for purchase and protocol details.

    Students:
    Work closely with students daily to exchange information.


    SUPERVISORY RESPONSIBILITY
    This position has no direct supervision of staff employees. Train new staff on common lab tasks and orientation; direct the work of students.


    QUALIFICATIONS

    Education and experience:

    Bachelor's degree and 1 to 3 years of related experience or Associate's degree in an approved biology program and 2 to 4 years of experience.


    REQUIRED SKILLS

    • Has knowledge of commonly-used concepts, practices, and procedures within the field of biology, immunology, biochemistry.
    • Follow instructions and pre-established guidelines to perform the functions of the job.
    • Ability to operate all the common laboratory equipment, such as: Pipettes, PCR Machine, Centrifuge, Biosafety Cabinets, Incubator, Tape Station, Nanodrop, Flow cytometer, and Microscope.
    • Ability to meet consistent attendance.
    • Ability to interact with colleagues, supervisors and clinical staff face to face.
    • Effective oral and written communication skills.
    • Good organization skills; ability to multi-task, prioritize and meet deadlines. Must demonstrate attention to detail and accuracy and follow-through on assigned tasks.
    • Ability to work with sensitive information and maintain confidentiality.
    • Good problem-solving skills; must demonstrate good analytical skills, sound judgment and good decision-making.
    • Familiarity with policies and procedures of lab and adhere to chemical and biological safety and manage them.
    • Computational knowledge necessary for research
    • Must be able and willing to maintain a high standard of personal cleanliness and utilize protective gear to protect the health of the animals.
    • Support the ongoing work of graduate students and postdocs

    WORKING CONDITIONS
    The physical work environment is a general laboratory environment. The employee will periodically work in Biosafety Level 2 (BSL-2) and BSL-2+ facilities.

    This job may include handling of primary biological specimens that may be infected with human pathogens, and may include using lentivirus, retrovirus, or AAV to infect human cells.

    The position will require handling of infectious materials, general laboratory chemicals (some of which are hazardous), blood-borne pathogens, repetitive motion (pipetting), and occasional DOT shipping or receiving of biological or infectious material.

    Personal protective equipment required for the job includes laboratory coat, eye protection, and gloves.

    Work hours will depend on the type of experiments and may involve early start, late finish, and working on weekends and holidays as required for specific experiments.

    May involve local travel for sample collection and collaborative work. This position may provide opportunities for travel to national conferences.

    Diversity Statement

    In employment, as in education, Case Western Reserve University is committed to Equal Opportunity and Diversity. Women, veterans, members of underrepresented minority groups, and individuals with disabilities are encouraged to apply.

    .

    Reasonable Accommodations

    Case Western Reserve University provides reasonable accommodations to applicants with disabilities.

    Applicants requiring a reasonable accommodation for any part of the application and hiring process should contact the Office of Equity at to request a reasonable accommodation.

    Determinations as to granting reasonable accommodations for any applicant will be made on a case-by-case basis.

  • Cleveland Clinic

    Research Assistant

    1 day ago

    Cleveland Clinic Cleveland, United States

    Join the Cleveland Clinic team, where you will work alongside passionate caregivers and provide patient-first healthcare. Cleveland Clinic is recognized as one of the top hospitals in the nation. At Cleveland Clinic, you will work alongside passionate and dedicated caregivers, re ...

  • Cleveland Clinic

    Research Assistant

    1 day ago

    Cleveland Clinic Cleveland, United States

    Join the Cleveland Clinic team, where you will work alongside passionate caregivers and provide patient-first healthcare. At Cleveland Clinic, you will work alongside passionate and dedicated caregivers, receive endless support and appreciation, and build a rewarding career with ...

  • The Cleveland Clinic

    Research Assistant

    2 days ago

    The Cleveland Clinic Cleveland, United States

    Assists research team with research study related tasks. Assists with the development and coordination of the research subject schedule in compliance with the research protocol. Assists with the collection, recording and maintenance of research study Research, Assistant, Healthca ...

  • Case Western Reserve University

    Research Assistant 1

    1 week ago

    Case Western Reserve University Cleveland, United States

    Working under moderate supervision, the Research Assistant 1 will perform research work in medical and related technical areas to support the DHRI's mission to ensure a better future for patients struggling with devastating digestive diseases, by tra Research, Assistant, Animal, ...

  • Case Western Reserve University

    Research Assistant 2

    1 week ago

    Case Western Reserve University Cleveland, United States

    Working under general supervision, the Research Assistant 2 will plan and carry out research projects in accordance with general plans. This position supports an NSF grant to study novel functions of proteins that form the occluding junction in Droso Research, Assistant, Biology, ...

  • Case Western Reserve University

    Research Assistant 1

    2 weeks ago

    Case Western Reserve University Cleveland, United States

    Working under moderate supervision, the Research Assistant 1 will perform research work in medial and related technical areas using lab skills, prepare samples for mass spectrometry analysis, operate mass spectrometers, and perform simple data analys Research, Assistant, Chemistr ...

  • Case Western Reserve University

    Research Assistant 2

    1 day ago

    Case Western Reserve University Cleveland, United States

    Job Description · POSITION OBJECTIVE · Working under general supervision, the primary role for this position is to coordinate a research study with the purpose of conducting a randomized control trial of a psychoeducational intervention designed to improve the self-efficacy of fa ...

  • Case Western Reserve University

    Research Assistant 2

    1 day ago

    Case Western Reserve University Cleveland, United States

    Working under general supervision, the Research Assistant 2 will perform and assist advanced research at the intersection of cancer biology, intracellular signal transduction, and membrane trafficking. The research assistant will join efforts to purs Research, Assistant, Public H ...

  • Case Western Reserve University

    Research Assistant 1

    1 week ago

    Case Western Reserve University Cleveland, United States

    Working under moderate supervision, perform research tasks to support the operations of Pulmonary, Critical Care, and Sleep Medicine including performing research work in medical and related technical areas. The research assistant will collect, verif Research, Assistant, Data Ent ...

  • Case Western Reserve University

    Research Assistant 1

    1 day ago

    Case Western Reserve University Cleveland, United States

    Working under moderate supervision of the project manager, the Research Assistant 1 will perform research in accordance with IRB-approved research protocols to support a PCORI funded study focusing on fatigue management for people with multiple scler Research, Assistant, HR, Data ...

  • Case Western Reserve University

    Research Assistant 1

    1 week ago

    Case Western Reserve University Cleveland, United States

    Job Description · POSITION OBJECTIVE · Working under moderate supervision, the Research Assistant 1 will perform research activities related to a research study focusing on self-management for people with Type 1 Diabetes in accordance with an IRB-approved protocol at University H ...

  • Case Western Reserve University

    Research Assistant 2

    1 day ago

    Case Western Reserve University Cleveland, United States

    Working under general supervision, the Research Assistant 2 will plan and carry out cellular, molecular and animal research projects in accordance with general plans. The lab utilizes cellular and animal models for studying tumor progression, metasta Research, Assistant, Animal, ...

  • Case Western Reserve University

    Research Assistant 1

    2 weeks ago

    Case Western Reserve University Cleveland, United States

    Working under moderate supervision, the Research Assistant 1 will perform research to support the investigation of pediatric neurodegeneration. This position will be primarily responsible for collaboratively performing laboratory experiments at the b Research, Assistant, Public H ...

  • Case Western Reserve University

    Research Assistant 2

    1 week ago

    Case Western Reserve University Cleveland, United States

    Job Description · POSITION OBJECTIVE · Working under general supervision, the research assistant will plan and carry out activities for a clinical research trial that involves exercise and psychotherapy in patients with comorbid pain and opioid addiction. Responsibilities include ...

  • Case Western Reserve University

    Research Assistant 1

    1 week ago

    Case Western Reserve University Cleveland, United States

    Job Description · POSITION OBJECTIVE · Working under moderate supervision, the Research Assistant 1 will perform research work with the goal of understanding how protein sequence alterations impact human disease or susceptibility to viral infection. The research assistant will ap ...

  • Case Western Reserve University

    Research Assistant 4

    1 day ago

    Case Western Reserve University Cleveland, United States

    Job Description · POSITION OBJECTIVE · Working with a high degree of independence and under general direction, the Research Assistant 4 will coordinate major activities in novel biomarker, diagnostic, and drug development for head and neck cancer. The research assistant will util ...

  • Case Western Reserve University

    Research Assistant 1

    1 day ago

    Case Western Reserve University Cleveland, United States

    Job Description · POSITION OBJECTIVE · Working under moderate supervision, the Research Assistant 1 will perform research work in medical and related technical areas involving the use of laboratory and research skills. The research assistant will primarily be responsible for runn ...

  • Case Western Reserve University

    Research Assistant 2

    1 day ago

    Case Western Reserve University Cleveland, United States

    Job Description · POSITION OBJECTIVE · Working under general supervision, the Research Assistant 2 will plan and carry out basic and preclinical research that endeavors to further delineate virus and host mechanisms that could be exploited to purge persistent reservoirs of HIV in ...

  • Case Western Reserve University

    Research Assistant 1

    1 day ago

    Case Western Reserve University Cleveland, United States

    Job Description · POSITION OBJECTIVE · Working under moderate supervision, the Research Assistant 1 will provide technical support and perform cancer-focused research with a selected faculty investigator to be determined. Working with the selected faculty member, the individual w ...

  • Case Western Reserve University

    Research Assistant 2

    1 week ago

    Case Western Reserve University Cleveland, United States

    Job Description · Position Objective · Working under general supervision, the Research Assistant 2 will plan and carry out research projects in accordance with general research guidelines. The responsibilities include planning and performing experiments on projects related to car ...