- supervise the site sequencing personnel, equipment, materials and process to ensure stable and orderly daily production
- Through knowledge of Sanger and Next Generation Sequencing(NGS) workflow, preparing DNA sequencing samples by organizing and setting up sequencing reactions, schedule sequencing runs on DNA analyzers
- Optimize and perform cleanup of sequencing reactions, operations knowledge of automated liquid handlers
- Lead sequencing team, track performance and participate in performance rating
- Analyze sequencing results, generate test reports, and give technical guidance to guide team members
- Evaluate sequencing run results, and coordinate with data analysis group
- Improve quality standards in sequence data generation, and lead key projects to continuously optimize sequencing workflow
- Perform instrument calibrations and regular maintenance including but not limited to DNA analyzers; acts as liaison with outside vendors relevant to sequencing instruments
- Troubleshoot instrument performance issues and make recommendations and/or adjustments to improve work efficiency
- Execute SOP through training and supervision. Continuously optimize SOP to improve operational efficiency
- Train and supervise lab personnel's, troubleshoot failed or poor results
- Keep abreast with the latest advancement in sequencing technologies, develop new protocols for streamlined as well as to handle complex workflow, and provide suggestions
- Responsible for team building and day to day management, including 5S, quality data generation, safety, and employee morale
- Other tasks as assigned
- Bachelor's or Master's degree in Biology, Biochemistry, Molecular Biology. Chemistry or related fields
- 2+ years of hands-on experience in DNA Sequencing platform(Sanger and/or NGS), analyzing DNA materials, sequencing workflow management, and data analysis
- Good understanding in the quantification and qualification methods of plasmid DNA, including spectrophotometric analysis, and electrophoresis
- Team management experience is preferred
- Must have experience working in a high throughput manufacturing environment, and flexible to modification in work environment
- Strong team management, communication and coordination skills
- Basic knowledge of molecular biology required, knowledge in project management, 5S management, quality management systems are preferred
- Experience with automation tools is preferred
- Have a strong sense of work responsibility and cost awareness
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Lab Supervisor/Manager - Piscataway, United States - GenScript
Description
Job Description
Job DescriptionAbout GenScript
GenScript Biotech Corporation (Stock Code: 1548.HK) is a global biotechnology group. Founded in 2002, GenScript has an established global presence across North America, Europe, the Greater China, and Asia Pacific. GenScript's businesses encompass four major categories based on its leading gene synthesis technology, including operation as a Life Science CRO, enzyme and synthetic biology products, biologics development and manufacturing, and cell therapy.
GenScript is committed to striving towards its vision of being the most reliable biotech company in the world to make humans and nature healthier through biotechnology
About GenScript ProBio
GenScript ProBio is the subsidiary of GenScript Biotech Corporation, proactively providing end-to-end CDMO service from drug discovery to commercialization with proactive strategies, professional solutions and efficient processes in cell and gene therapy (CGT), vaccine, biologics discovery and antibody protein drug to accelerate drug development for customers. GenScript ProBio's total cell and gene therapy solution covers CMC of plasmid and virus for IND filing as well as clinical manufacturing and commercial manufacturing. In terms of plasmid service, GenScript ProBio supports the most clinical approvals for CGT drugs including mRNA vaccines, CAR-T in China. It is also the first GMP manufacturing platform to provide in vitro transcription (IVT) template linearized plasmids for mRNA vaccines and has supported several mRNA vaccine global enterprises to obtain clinical approvals. In terms of viral vector service, GenScript ProBio has a stable and high-yield viral vector platform.
Job Scope:
We are looking for a Supervisor of DNA Sequencing Lab as part of US Based, highly automated gene synthesis operations. The incumbent will work with the Director, Manager, staff research associate/technicians, and laboratory assistants in a multi-disciplinary manufacturing environment; supports in daily operation, maintenance, and systematic workflow of the DNA sequencing facility. The candidate in this position is responsible for training and supervision of laboratory assistants/technicians, coordinating with the relevant stakeholders in the manufacturing operations, and also sets up efficient scheduling of sequencing workflow for a minimum turnaround time. The position is also expected to help with the data analysis/bioinformatics of full DNA/plasmid sequencing data.
Key Responsibilities:
Qualifications
#GS
#LI-LW1
GenScript USA Inc/GenScript ProBio USA Inc. is a proud equal opportunity/affirmative action employer committed to attracting, retaining, and maximizing the performance of a diverse and inclusive workforce. It is the Company's policy to ensure equal employment opportunity without discrimination or harassment based on race, color, religion, sex (including pregnancy, childbirth, or related medical conditions), sexual orientation, gender identity or expression, age, disability, national origin, marital or domestic/civil partnership status, genetic information, citizenship status, uniformed service member or veteran status, or any other characteristic protected by law.
GenScript USA Inc./GenScript ProBio USA Inc. maintains a drug-free workplace.
