Joseph Dobosy

Seasoned and innovative molecular biology scientist with over 18 years performing, overseeing, and evaluating research projects within the biotechnology industry. Skilled scientific professional with extensive experience in laboratory research, data presentation, management, and intellectual property writing. Possessing exceptional laboratory skills to support the delivery of accurate research results. Talents include an in-depth knowledge of enzyme screening, mutagenesis, and characterization. Experienced in epigenetics research, focusing on DNA methylation and histone acetylation. Highly skilled in both DNA and RNA nucleic acid analysis, while maintaining exceptional ethical and quality standards.

Developed innovative RNase H2-dependant PCR (IDT rhAMPTM) methodologies. These novel techniques are incorporated in multiple products, including IDT’s rhAmpSNPTM, high-multiplex NGS (IDT rhAmpSeqTM), and rare allele detection. 

Oversaw development and testing of novel Taq DNA polymerase mutants with enhanced mismatch discrimination ability, creating both patents and products for IDT. 

Invented, characterized and patented multiple novel RNase H2 enzyme mutants, with enhanced mismatch discrimination ability. 

Created techniques and led development for the creation of long single-stranded DNA products (IDT MegamersTM). 

Led the development and characterization of multiple chemically hot start modified enzymes, including Taq polymerase and RNase H2. 

Led the IDT development of unique molecular identifiers beads for NGS analysis 

Guided subordinate team research, distributing workload and assigning tasks. 

Drafted intellectual property documentation for company product protection, resulting in over 30 patents for IDT.  

Senior Staff Scientist Aug 2007 – April 2025 (Current) 

Integrated DNA Technologies, Coralville, IA 

Performing and overseeing bench work on a wide variety of molecular biology and biochemistry projects while ensuring that the associated products are completed to time, budget, and customer requirements. 

Developed innovative RNase H2-dependant PCR (IDT rhAMPTM) methodologies. These novel techniques are incorporated in multiple products, including IDT’s rhAmpSNPTM, high-multiplex NGS (IDT rhAmpSeqTM), and rare allele detection. 

Oversaw development and testing of novel Taq DNA polymerase mutants with enhanced mismatch discrimination ability, creating both patents and products for IDT. 

Invented, characterized and patented multiple novel RNase H2 enzyme mutants, with enhanced mismatch discrimination ability. 

Created techniques and led development for the creation of long single-stranded DNA products (IDT MegamersTM). 

Led the development and characterization of multiple chemically hot start modified enzymes, including Taq polymerase and RNase H2. 

Led the IDT development of unique molecular identifiers beads for NGS analysis 

Guided subordinate team research, distributing workload and assigning tasks. 

Drafted intellectual property documentation for company product protection, resulting in over 30 patents for IDT. 

Postdoctoral researcher    Month/Year of Completion 

University of Wisconsin, Madison           August 2007 

Research on chromatin and gene expression analysis in prostate cancer in both animal and human models. 

Doctor of Philosophy (Ph.D.) 

University of Oregon, Eugene            March 2003 

Research on histone modifications control over DNA methylation in the filamentous fungus N. crassa.