Investigator, Modelling and Simulation - Collegeville, United States - GSK

GSK

Verified Company

Collegeville, United States

1 day ago

Posted by:

Mark Lane

beBee recruiter

Description

Site Name:
USA - Pennsylvania - Upper Providence

Posted Date:
Apr

This role will provide YOU the opportunity to lead key activities to progress YOUR career.

These responsibilities include the following:

As part of matrix project teams, develop and deploy mechanistic, data driven, and hybrid modelling solutions for sterile drug products and large molecule drug substance.
Use engineering, chemical, biological, and materials science knowledge to postulate mechanisms for physiochemical processes and develop or modify existing mathematical models to describes those mechanisms.
Design experimentation and analysis required to develop and verify system models.
Develop product performance models. Build systemsbased understanding of sterile drug products integrating materials science understanding, process, and product performance models.
Translate mathematical models to computer models using software platforms (e.g., gPROMS) or by writing custom programs.
Understand the requirements to develop modelbased soft sensors and model predictive control.
Work closely with the Quality, Regulatory and other experts to integrate process modelling approaches into QbD process development for small molecule drug substance.
Work closely with Statistical Sciences to develop the best insilico experimental design and to engage them to assess model uncertainty and model predictive confidence limits.
Stay current with new modelling techniques through publications, conferences and academic and precompetitive collaborations.
Track progress against deliverables and maintain a communication plan with stakeholders and partners across departments.
Advocate and comply with GMP requirements for recording experiments and associated data, and writing reports, including scientific review and data checking.
Comply with the requirements of Quality, Safety, and GSK policies and procedures and ensure that GSK intellectual property is protected.

_ Why you?_:

Basic Qualifications:

We are looking for professionals with these required skills to achieve our goals:

in Chemical Engineering, Chemistry, Materials Sciences with an emphasis on development and implementation of mechanistic mathematical models and / or data driven modelling approaches for sterile drug products or large molecule drug substance operations.

Experience translating mathematical models into computer programs using MATLAB, Python, or similar software tools.
An understanding of statistical science and related software tools that enable sound experimental design and interpretation of models.

Preferred Qualifications:

If you have the following characteristics, it would be a plus:

2+ years of previous industry or post-doctoral experience
Publications in peer reviewed journals.
Experience in system modelling and platforms such as gPROMs.
Understanding of in vitro and in vivo product performance modelling.
Prior experience working on modelbased soft sensors and development of digital twins.
Good interpersonal, organizational and communications skills.
LI-GSK

Please visit GSK US Benefits Summary to learn more about the comprehensive benefits program GSK offers US employees.

Why Us?

GSK is a global biopharma company with a special purpose - to unite science, technology and talent to get ahead of disease together - so we can positively impact the health of billions of people and deliver stronger, more sustainable shareholder returns - as an organization where people can thrive.

Getting ahead means preventing disease as well as treating it, and we aim to positively impact the health of 2.5 billion people by the end of 2030.

Our success absolutely depends on our people.

While getting ahead of disease together is about our ambition for patients and shareholders, it's also about making GSK a place where people can thrive.

We want GSK to be a workplace where everyone can feel a sense of belonging and thrive as set out in our Equal and Inclusive Treatment of Employees policy.

We're committed to being more proactive at all levels so that our workforce reflects the communities we work and hire in, and our GSK leadership reflects our GSK workforce.

GSK is an Equal Opportunity Employer and, in the US, we adhere to Affirmative Action principles.

This ensures that all qualified applicants will receive equal consideration for employment without regard to race, color, national origin, religion, sex, pregnancy, marital status, sexual orientation, gender identity/expression, age, disability, genetic information, military service, covered/protected veteran status or any other federal, state or local protected class.

Important notice to Employment businesses/ Agencies
Please note that if you are a US Licensed Healthcare Professional or Healthcare Professional as defined by the laws of the state issuing your license, GSK may be required to capture and report expenses GSK incurs, on your behalf, in the event