- Work with discovery scientists within J&J Innovative Medicine to design and execute studies to further our understanding of mechanisms of resistance to T cell redirection therapeutics (ie. Bispecific/multispecific antibodies and CART), with a focus on the multiple myeloma (MM) disease area
- Integrate internal and external data in the design and interpretation of experiments
- Develop and utilize assays to mimic bone marrow-like conditions
- Investigate MM protein biology
- Use CRISPR/Cas9 screening technologies
- Design and analyze multi-color flow cytometry experiments to characterize immune cell function (e.g., celesta, fortessa, symphony)
- Perform advanced molecular and cellular biology techniques (e.g., viral and non-viral cell transduction, Western blot, DNA/RNA isolation, and qRT-PCR)
- Perform functional T cell redirection assays using bispecific/multispecific antibodies and CART cell therapy
- Maintain detailed and organized experimental records and stay compliant on all relevant internal and external training requirements
- Communicate scientific results to multidisciplinary teams including computational biologists, bench scientists, clinicians, and management in an appropriate biological context
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Postdoctoral Fellow- Oncology Discovery - Spring House, United States - Johnson & Johnson
Description
At Johnson & Johnson, we believe health is everything.Our strength in healthcare innovation empowers us to build a world where complex diseases are prevented, treated, and cured, where treatments are smarter and less invasive, and solutions are personal.
Through our expertise in Innovative Medicine and MedTech, we are uniquely positioned to innovate across the full spectrum of healthcare solutions today to deliver the breakthroughs of tomorrow, and profoundly impact health for humanity.
Learn more at
The Post-doctoral Research Scientist-Oncology Discovery Hematological Malignancies [focused on Multiple Myeloma (MM)] will work independently on a project designed to further the understanding of MM and hematological malignancy biology with the goal of investigating mechanisms of T cell engager resistance.
You will have the ability to work with and learn from experts within discovery oncology research, specialized in cell and molecular biology, flow cytometry, computational biology, and in vivo sciences, while also leveraging additional resources at J&J Innovative Medicine.
The length of the position will be 2 years, the candidate is expected to present and publish their research.In this role you will:
