Nanoparticle Formulation Library Scientist - Monrovia, United States - Rampart Bioscience

Rampart Bioscience Monrovia, United States

1 week ago

Pharmaceutical / Bio-tech

Description

Nanoparticle Formulation Library Scientist

Who We Are

Rampart Bioscience is an early-stage biotechnology company pioneering a new class of medicines for individuals, especially children, living with genetically driven diseases. Powered by its non-viral DNA vector platform, Rampart's mission is to develop transformative medicines that achieve higher standards for potency and safety than current gene therapies. Rampart is funded by several global, top-tier healthcare investment firms, and is led by seasoned experts in gene delivery, protein sciences, and clinical translation.

When you join Rampart, you are not simply advancing your career. You are joining a team that is dedicated to realizing the potential of gene therapy to provide effective, safe, and long-lasting treatments for a wide range of diseases. We are mission-driven and guided by our values:

· People first. Nothing shall be done to harm human dignity or get in the way of one's freedom.

· Unbound by convention. We embrace the unfamiliar and are willing to stand alone together.

· Actions speak. We have a bias for action and serve with humility as we work to achieve new ground.

· Relationships matter. We build authentic relationships founded on trust, integrity, diligence, and honor.

· We care. We are disciplined and passionate. We love what we do, who we do it with, and who we do it for.

As we advance our work in exciting ways, we are selectively hiring talented team members to join us in our Southern California locations. For more information, please visit

About The Job:

Rampart Bioscience is currently seeking a Nanoparticle Formulation Library Scientist.

You will report to the Director of Nanoparticle Formulation and will be working with our growing team on the development of vehicles to enable delivery of the Company's non-viral DNA-based gene therapy. You will research, develop, and optimize nanoparticle formulation libraries for various applications that achieve desired properties. Additionally, in this role you will work with others to complete cross-functional projects, such as developing formulation technologies that enable rapid imaging-based screening approaches. The ideal candidate will be highly detail- and task-oriented, have a collaborative mindset, and will be comfortable in a fast-paced environment.

Key Responsibilities:

· Design experiments, analyze data, and create libraries of nanoparticle formulations that can be used for DNA delivery across multiple applications and target organs.

· Evaluate formulation parameters, nanoparticle characteristics, and assess performance in targeted applications.

· Iterate on formulation design to achieve desired properties and functionality, such as drug delivery efficiency.

· Develop formulations and corresponding technologies that enable rapid screening approaches, such as those that utilize advanced imaging techniques.

· Support scale-up activities, as required.

· Present results of work at internal meetings.

Qualifications/Requirements:

· A PhD in Chemistry, Biochemistry, Biophysics or Pharmaceutical Sciences, with more than 2 years of direct experience (may include postdoctoral experience) in design and development of lipid nanoparticle LNP-based, or polymer nanoparticle (PN)-based nucleic acid delivery systems.

· Expertise in developing liquid, frozen, and lyophilized formulations of lipid based nucleic acid formulations.

· Expertise and knowledge in scale up of formulation production and purification unit operations and tech transfer activities.

· An in-depth understanding of all aspects of formulation development as well as downstream characterization including physico-chemical, stability, and biological evaluation.

· An independent thinker with a passion for developing innovative formulation technologies.

· Excellent scientific publication, patent, and/or presentation record in the field of lipid nanoparticle-based drug delivery systems.

· Background in designing assays for screening DNA delivery systems.

· Knowledge and understanding of PK/PD aspects of lipid nanoparticle-based formulations.

· Deep knowledge of design of experiment workflow.

· Leadership and mentoring skills.

· Excellent oral and written communication skills.

Compensation, Benefits & Additional Information

Compensation range: $105,000 - $130,000 commensurate with qualifications and dependent on the position.

We are proud to provide a robust benefits package for our employees, including:

Medical, dental and vision insurance for employees and their dependents, with a 90% - 100% company contribution.

Life, AD&D and disability insurance for employees, with a 100% company contribution.

401(k).

Generous amounts of paid time off through our vacation, holiday, sick and floating time off programs including floating "beach" days and your birthday off.

Ability to participate in the company's Stock Benefit Plan and annual Bonus Plan.

***Please attach a cover letter with your resume stating why you are a good fit for Rampart Bio.****

Rampart Bioscience is proud to be an equal opportunity employer, seeking to create a welcoming and diverse environment. All applicants will receive consideration for employment without regard to race, color, religion, gender, sexual orientation, national origin, disability, age, veteran status or any other applicable legally protected characteristics.

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