- Execute in vitro and in vivo studies to support IND-enabling data packages.
- Conduct preclinical studies to evaluate efficacy and persistence of allogeneic CAR T cells in orthotopic tumor models.
- Generate CAR T cells and test functionality in in vitro assays.
- Perform phenotypic analysis of engineered CAR T cells using multicolor flow cytometry.
- Provide critical lab support and contribute to a collaborative team-oriented environment.
- Design and perform experimental plans with minimal guidance, document laboratory procedures and analyze and record data.
- Present at group meetings and project team meetings.
- Other duties as assigned.
- Bachelor's Degree in Biology or related discipline or Master of Science degree with experience in academic or industry setting.
- Experience in cell therapy, cellular biology, or immunology.
- Extensive in vivo skillset is required, including tumor inoculation and measurement (BLI imaging, caliper), animal dosing (i.v., i.p., and s.c.), blood/tissue collection and ex vivo analysis.
- Direct experience with tissue culture of cell lines and primary cells.
- Experience with T cell viral transduction and expansion is preferred.
- Direct experience performing in vitro functional assays is preferred, including cytotoxicity, proliferation, multi-color flow cytometry and cytokine release.
- Proficiency in the use of software tools to support data analysis (e.g., Prism, FlowJo).
- A willingness to learn and adopt new experimental skills as needed is essential.
- Excellent organizational skills and an ability to prioritize effectively to deliver results within reasonably established timelines.
- Comfortable in a fast-paced small company environment with minimal direction and able to adjust workload based upon changing priorities.
- Strong interpersonal skills including verbal and written communication are essential in this collaborative work environment.
- Ability to work independently and as part of a team.
- Candidates must be authorized to work in the U.S.
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Senior Associate Scientist, In Vitro - South San Francisco, United States - Allogene Therapeutics, Inc.
Description
About Allogene:
Allogene Therapeutics, with headquarters in South San Francisco, is a clinical-stage biotechnology company pioneering the development of allogeneic chimeric antigen receptor T cell (AlloCAR T) products for cancer and autoimmune disease.
Led by a management team with significant experience in cell therapy, Allogene is developing a pipeline of "off-the-shelf" CAR T cell product candidates with the goal of delivering readily available cell therapy on-demand, more reliably, and at greater scale to more patients.
For more information, please visit , and follow @AllogeneTx on X (formerly Twitter) and LinkedIn.About the role:
Allogene Therapeutics is seeking a highly motivated Senior Associate Scientist in the Research department. The position will be located at our headquarters in South San Francisco, CA.
The ideal candidate is an individual who is interested in working in a fast-paced, dynamic, and highly collaborative biotech environment with a willingness and ability to successfully take on new challenges.
We encourage applicants who believe they have the skills and drive to succeed at Allogene to apply for this role.
Responsibilities include, but are not limited to:
Position Requirements & Experience:
We offer a chance to work with talented people in a collaborative environment and provide a top-notch compensation and benefits package, which includes an annual performance bonus, equity, health insurance, generous time off (including 2 annual holiday company-wide shutdowns) and much more.
Actual pay will be determined based on experience, qualifications, geographic location, business needs, and other job-related factors permitted by law.
As an equal opportunity employer, Allogene is committed to a diverse workforce.Employment decisions regarding recruitment and selection will be made without discrimination based on race, color, religion, national origin, gender, age, sexual orientation, physical or mental disability, genetic information or characteristic, gender identity and expression, veteran status, or other non-job-related characteristics or other prohibited grounds specified in applicable federal, state and local laws.
We also embrace differences in experience and background, and welcome diversity of opinions and thought with active recruitment and internships designed to create a stronger and better Allogene that is focused on developing life-changing products for patients.
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