- Purification of DNA repair proteins RAD51, RAD52, RDM1, RPAs, PARP1, DNA helicases, etc. for structural and biophysical analysis, and for small molecule drug discovery.
- Analysis of the nucleoprotein complexes by CryoEM and X-ray crystallography (sample and greed preparation, screen, data collection and data analysis).
- Writing proposals for time on the CryoEM instruments at national facilities.
- Teaching junior lab members in using biochemical and structural techniques.
- Perform library research on topics studied, prepare research materials for reports, and assist in the preparation of papers for publication.
- Present the data at regional, national and/or international meetings.
- Order general laboratory supplies, maintain equipment, and sustain laboratory organization.
- Analyze and interpret data with the help of others in the laboratory, and determine the validity of the results. Keep detailed laboratory notebooks recording experimental data and analyses and present these findings at weekly lab meetings. Recommend further experiments and/or changes in procedures.
- Other duties as assigned.
- Welcoming - We strive for an environment where everyone has a voice that is heard, that promotes the dignity of our patients, trainees, and employees, and allows all to thrive in their health, work, research, and education.
- Excellence - We aim to achieve and deliver our personal and collective best in the pursuit of quality and accessible healthcare, education, and research.
- Collaboration - We encourage collaboration with healthcare systems, providers, and communities across Iowa and the region, as well as within our UI community. We believe teamwork - guided by compassion - is the best way to work.
- Accountability - We behave ethically, act with fairness and integrity, take responsibility for our own actions, and respond when errors in behavior or judgment occur.
- Respect - We are committed to ensuring that UI Health Care is an inclusive environment where individuals from the full spectrum of diversity - which includes identity, backgrounds, cultures, ability and perspective -feel safe, seen, and valued.
- Equity - We dedicate ourselves to equity and fairness in research, health care, education and health.
- Structural and biochemical analysis of protein-DNA interactions
- CryoEM sample preparation, data collection and model building
- Experience in purifying and working with human DNA repair proteins.
- Proficiency in computer use (Windows and Office applications, GraphPad Prism, contemporary CryoEM and X-ray crystallography software).
- Demonstrated excellent written and verbal communication skills
- Strong organizational skills
- Knowledge of the fundamental mechanisms of homologous recombination, DNA repair, DNA replication, genome stability
- Experience with bacterial and mammalian cell culture
- Resume
- Cover Letter
- Classification Title: Asst Research Scientist/Engin
- Appointment Type: Professional and Scientific
- Schedule: Full-time
- Work Modality Options: On Campus
- Pay Level: PRJ1
- Organization: Healthcare
- Contact Name: Rosemary Stratton
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Assistant Research Scientist-Biochemistry and Molecular Biology - Iowa City, United States - University of Iowa
Description
BASIC FUNCTION AND RESPONSIBILITY
This person will work in the research laboratory of Dr.
Maria Spies on the structural (CryoEM and X-ray crystallography) studies of the molecular machines maintaining human genome stability, and on structure-based drug discovery.
This person will be responsible for the generation and interpretation of experimental data, presentation of the data at scientific meetings, drafting the scientific manuscripts describing the data and assisting in the daily operations of the laboratory.
This person will be also encouraged to apply for extramural and/or intramural funding.CHARACTERISTIC DUTIES AND RESPONSIBILITIES
SUPERVISION RECEIVED
Functional supervision is received from the Principal Investigator.
WE CARE CORE VALUES
Department Summary:
For additional information about the Department of Biochemistry and Molecular Biology at the University of Iowa, please visit our website at:
BASIC QUALIFICATIONS
PhD in chemistry, biochemistry, structural biology, or related scientific discipline. Prior postdoctoral experience. Strong publication record. Expertise in CryoEM, X-ray crystallography and biochemical analysis of protein-DNA interactions, fluorescence spectroscopy, and HTS. Experience in purifying and working with human DNA repair proteins. Proficiency with Linux and PC.
EXPERIENCE REQUIRED
DESIRABLE QUALIFICATIONS
POSITION AND APPLICATION DETAILS
To be considered, applicants must upload the following documents and mark them as "Relevant File" to the submission:
Job openings are posted for a minimum of 14 calendar days and may be removed from posting and filled any time after the original posting period has ended.
Successful candidates will be required to self-disclose any conviction history and will be subject to a criminal background check and credential/education verification.
For additional questions, please contact Rosemary Stratton at rosemary-Additional Information
