Jobs

    Lab Manager - Stanford, CA, United States - Stanford University

    Stanford University
    Stanford University Stanford, CA, United States

    3 weeks ago

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    Description

    We are seeking a highly motivated and organized individual to join us as a Lab Manager and Research Associate in Genomics and Heart Disease.

    In this role, the candidate will support three interrelated laboratories (Jesse Engreitz, Casey Gifford, and Xiaojie Qiu) in the Stanford Children's Heart Center Basic Science and Engineering Initiative and Department of Genetics, which are all located together in the Biomedical Innovations Building on Stanford main campus.


    Lab overview:
    Our overall mission is to leverage advances in genetics and genomics to cure children's heart diseases.

    In particular, DNA regulatory elements in the human genome, which harbor thousands of genetic risk variants for common and rare heart diseases and could reveal targets for therapeutics that aim to precisely tune cellular functions — if only we could map the complex regulatory wiring that connects 2 million regulatory elements with 21,000 genes in thousands of cell types in the human body.

    We have recently developed new approaches that could enable mapping this regulatory wiring at massive scale (see Fulco et al. Science 2016, Fulco et al.

    Nature 2021), and applied these and other approaches to understand the genetic basis of congenital heart defects (Gifford et al.

    Science 2019, Schricker et al.

    We have now identified enhancers that contain disease variants that affect risk for congenital heart defects, and aim to study the functions of these enhancers in mouse models and human cardiac organoids.

    These studies will ultimately help to uncover biological mechanisms of congenital heart defects, and help to guide diagnosis and treatment for children with heart disease.

    We are looking for a creative and passionate person at any stage in their career to lead management of our combined experimental/computational laboratory.

    The Gifford, Engreitz, and Qiu Laboratories are located adjacent to one another and provide a dynamic, interdisciplinary workplace with unique access to cutting edge technologies and scientific thought, with the potential for widespread recognition of scientific contributions.

    We value a diversity of values, backgrounds, and approaches to solving problems.

    The candidate for this position should have hands-on experience in molecular biology, genomics, and cellular assay development; experience building or managing teams; ability to adapt to and effectively manage changes in a fast paced and dynamic environment; and have a passion for science and sense of urgency to find new medicines to benefit patients.

    Candidates with or without prior laboratory management experience are welcome to apply. On-the-job training will be provided.

    In addition to submitting your application via the Stanford web portal, please email your CV and cover letter directly to Profs.

    Make fundamental discoveries about gene regulation and the genetics of cardiovascular disease
    Together with PIs, oversee lab management including protocols, procedures, inventory, and training
    Train, mentor, and/or supervise lab members in experimental techniques, scientific design, and laboratory safety protocols
    Coordinate ordering for all lab members and maintain a database to manage these orders. Assist with budgeting and financial overviews, including compiling and reporting purchasing data and streamlining inventory and costs
    Develop organizational tools to improve productivity of lab
    Maintain and update laboratory protocols
    Oversee lab safety compliance and communicate with safety committees and groups, as well as participate in lab inspections.
    Coordinate the repair, evaluation, service contracts, calendar system, and annual certifications of lab equipment.
    Maintain a current chemical inventory.
    Oversee the maintenance of cold storage units, including liquid nitrogen.
    * - S. in Biology, Biochemistry, Biophysics, Genetics, or related life science field. Hands-on experience in molecular biology or genomics
    Experience with quantitative data analysis, CRISPR, and/or single-cell methods a plus
    Curiosity in research and creativity in problem-solving
    Previous leadership or lab management experience a plus
    Ability to adapt to and effectively manage changes in a fast paced and dynamic environment
    A passion for science and sense of urgency to find new medicines to benefit patients

    EDUCATION & EXPERIENCE (REQUIRED): Bachelor's degree in related scientific field and two years of relevant work experience; or Master's degree in a related scientific field.

    Comprehensive understanding of scientific principles.
    General computer skills and ability to quickly learn and master computer programs, databases, and scientific applications.

    Frequently stand, walk, twist, bend, stoop, squat, grasp lightly, use fine manipulation, grasp forcefully, perform desk-based computer tasks, use telephone, write by hand, lift, carry, push and pull objects weighing over 40 pounds.

    Occasionally sit, kneel, crawl, reach and work above shoulders, sort and file paperwork or parts.

    Consistent with its obligations under the law, the University will provide reasonable accommodation to any employee with a disability who requires accommodation to perform the essential functions of his or her job.

    May require work in an environment where animals are used for teaching and research.

    Position may at times require the employee to work with or be in areas where hazardous materials and/or infectious diseases are present.

    Employee must perform tasks that require the use of personal protective equipment, such as safety glasses and shoes, protective clothing and gloves, and possibly a respirator.

    May require extended or unusual work hours based on research requirements and business needs.

    The Cardinal at Work website () provides detailed information on Stanford's extensive range of benefits and rewards offered to employees.

    uses and promotes safe behaviors bases on training and lessons learned.

    Subject to and expected to comply with all applicable University policies and procedures, including but not limited to the personnel policies and other policies found in the University's Administrative Guide, .


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