- Provide cross-functional project team leadership to create a portfolio of therapeutic assets
- Contribute to insitro's strategy in Metabolic Disease focusing on obesity and liver diseases (with future expansion into the cardio space)
- Conceptualize and design strategies for drug discovery using insitro's platforms from hit to lead using industry standard preclinical pharmacology models and standard drug development models by applying insights exposed by insitro's unique target discovery credentialization
- Provide regular updates to Executive team on project plans, vision and status
- Lead efforts to follow up on targets with the goal of producing viable therapeutic interventions
- Lead external collaborations with partners and other organizations and individuals in efforts related to hit-to-lead in the Metabolic Disease area
- PhD in a biological science related field (Pharmacology, Genetics, Biochem etc.) with 8+ years of industry experience in drug discovery.
- A strong scientific track record in Metabolic Disease, obesity/adiposityand/or cardio and contribution to delivering multi-modality drug candidates and contribution to INDs.
- Experience leading and influencing a high-performing team of scientists
- Demonstrated track record of leading cross-functional project teams, building partnerships and collaborations with scientists of diverse disciplines
- Capable of communicating effectively and collaborate with people of diverse backgrounds and job functions, including a track record of collaborating with life scientists
- Strong interpersonal skills that motivates others to excel and achieve their very best
- Ability to chart the course in a clear and direct manner
- Experience with multi modalities for drug candidates
- Experience in navigating efficacy and safety studies in preclinical models
- Understanding of standard drug development process, defining in vivo pharmacology, assessing PKPD and deriving margins to provide clinical starting doses
- 401(k) plan with employer matching for contributions
- Excellent medical, dental, and vision coverage (insitro pays 100% of premiums for employees on our base plans), as well as mental health and well-being support
- Open, flexible vacation policy
- Paid parental leave
- Quarterly budget for books and online courses for self-development
- Support to occasionally attend professional conferences that are meaningful to your career growth and development
- New hire stipend for home office setup
- Monthly cell phone & internet stipend
- Access to free onsite baristas and cafe with daily lunch and breakfast
- Access to free onsite fitness center
- Commuter benefits
-
Principal Scientist, Metabolic Diseases
2 weeks ago
Insitro South San Francisco, United StatesThe Opportunity · The heart of insitro's strategy is the combination and application of machine learning to disease biology at scale, and novel analyses from clinical and cellular datasets that address key shortcomings in the target discovery and drug development process. To acco ...
-
Registered Dietitian-Part Time
4 weeks ago
FRESENIUS MEDICAL CENTER San Francisco, United States Part timePURPOSE AND SCOPE: · Provides nutritional services for the facility's in-center and home patients as applicable in order to maximize the patient's nutritional status and improve clinical outcomes. Functions as a member of the interdisciplinary healthcare team, supporting the FMCN ...
-
InsideHigherEd San Francisco, United States Faculty Jobs ,· Lecturer - Department of Nutritional Sciences and Toxicology - Rausser College of Natural Resources · Position overview Position title: Lecturer · Salary range: The UC academic salary scales set the minimum pay at appointment. See the following table(s) for the current salary ...
-
89bio San Francisco, United StatesTHE COMPANY · 89bio is a clinical-stage biopharmaceutical company focused on the development and commercialization of innovative therapies for the treatment of liver and cardio-metabolic diseases. The company's lead product candidate, pegozafermin (BIO89-100), is a specifically ...
-
89bio San Francisco, United StatesTHE COMPANY · 89bio is a clinical-stage biopharmaceutical company focused on the development and commercialization of innovative therapies for the treatment of liver and cardio-metabolic diseases. The company's lead product candidate, pegozafermin (BIO89-100), is a specifically ...
-
Senior Research Associate
1 week ago
Deciduous Therapeutics San Francisco, United StatesSenior Research Associate – Immunology · Deciduous Therapeutics is an early-stage, venture-backed biotechnology company based in San Francisco, CA. Our mission is to develop novel drugs that activate the endogenous immune system to eliminate senescent cells for treating age-rel ...
-
Accounting Operations, Senior Manager 89bio
2 weeks ago
snaphire San Francisco, United States89bio is a clinical-stage biopharmaceutical company focused on the development and commercialization of innovative therapies for the treatment of liver and cardio-metabolic diseases. The company's lead product candidate, pegozafermin (BIO89-100), is a specifically engineered glyc ...
-
Accounting Operations, Senior Manager
2 weeks ago
89bio San Francisco, United StatesTHE COMPANY89bio is a clinical-stage biopharmaceutical company focused on the development and commercialization of innovative therapies for the treatment of liver and cardio-metabolic diseases. The company's lead product candidate, pegozafermin (BIO89-100), is a specifically engi ...
-
Senior Scientist, In Vitro Pharmacology
4 weeks ago
Altos Labs San Francisco, United StatesOur Mission · Our mission is to restore cell health and resilience through cell rejuvenation to reverse disease, injury, and the disabilities that can occur throughout life. · Our Value · Our Single Altos Value: Everyone Owns Achieving Our Inspiring Mission. · Diversity at Altos ...
-
CMC Operations
4 weeks ago
89bio San Francisco, United StatesTHE COMPANY · 89bio is a clinical-stage biopharmaceutical company focused on the development and commercialization of innovative therapies for the treatment of liver and cardio-metabolic diseases. The company's lead product candidate, pegozafermin (BIO89-100), is a specifically ...
-
Supply Chain, Senior Manager
3 weeks ago
89bio San Francisco, United StatesTHE COMPANY · 89bio is a clinical-stage biopharmaceutical company focused on the development and · commercialization of innovative therapies for the treatment of liver and cardio-metabolic diseases. The company's lead product candidate, pegozafermin (BIO89-100), is a specifically ...
-
CMC Operations
4 weeks ago
89bio San Francisco, United StatesTHE COMPANY · 89bio is a clinical-stage biopharmaceutical company focused on the development and commercialization of innovative therapies for the treatment of liver and cardio-metabolic diseases. The company's lead product candidate, pegozafermin (BIO89-100), is a specifically ...
-
InsideHigherEd San Francisco, United States Faculty Jobs ,· Instructor Pool Biological, Chemical, and Physical Sciences - UC Berkeley Extension · Position overview · Salary range: A reasonable estimate for this position is $2,750-$6,800 per course, or $170-$200/student for an asynchronous online course. Instructor compensation is dete ...
-
InsideHigherEd San Francisco, United States Faculty Jobs ,· Instructor Pool Biological, Chemical, and Physical Sciences - UC Berkeley Extension · Position overview · Salary range: A reasonable estimate for this position is $2,750-$6,800 per course, or $170-$200/student for an asynchronous online course. Instructor compensation is dete ...
-
InsideHigherEd San Francisco, United States Faculty Jobs ,· Instructor Pool Biological, Chemical, and Physical Sciences - UC Berkeley Extension · Position overview · Salary range: A reasonable estimate for this position is $2,750-$6,800 per course, or $170-$200/student for an asynchronous online course. Instructor compensation is dete ...
-
Postdoctoral Fellow, In Vivo Metabolism
2 weeks ago
California Life Company San Francisco, United StatesPosition description: · Calico is seeking a Postdoctoral Fellow who is excited to be part of a scientific team dedicated to unraveling the fundamentals of the aging process. We are looking for a scientist with a strong background in cellular and in vivo metabolism interested in a ...
-
Third Rock Ventures San Francisco, United Statesinsitro is using machine learning to yield entirely new, clinically actionable insights into critical unmet needs for patients. We aim to "go fast and improve things" across the entire drug development process from platform to pipeline to patients and back again. · The Senior Med ...
-
Postdoctoral Scholar- Jain Lab
2 weeks ago
BioSpace San Francisco, United StatesJob Details · Category:Postdoc · Lab/Area:Jain Lab · Description: · Postdoc Position to Study Vitamin and Oxygen Metabolism in Jain Lab at Gladstone · The Jain Lab ( ) is looking for motivated, hard-working and curious applicants. We recently discovered that chronic hypoxia (equ ...
-
Physician - Locums-to-Permanent
3 weeks ago
Pacific Companies, Inc. San Francisco, CA, United StatesThe locum tenens Pediatric Gastroenterologist opportunity in the bay area of California. Must have an active California license -Duration: June 2018 for 3+ months-Coverage: Anywhere from 1-4 weeks per month (per your availability)-Call: Rotating 1:3, light call back-Procedures: 2 ...
-
Associate Scientist II
2 weeks ago
Third Rock Ventures San Francisco, United StatesThe heart of Insitro's strategy is the development of novel, cutting edge methods in machine learning and high-throughput biology that address key bottlenecks in the drug development pipeline. Metabolic dysfunction-associated steatotic liver disease (MASLD) is a growing epidemic ...
Principal Scientist, Metabolic Diseases - San Francisco, United States - Third Rock Ventures
Description
The heart of insitro's strategy is the combination and application of machine learning to disease biology at scale, and novel analyses from clinical and cellular datasets that address key shortcomings in the target discovery and drug development process.
To accomplish that, we are putting together an incredible team of highly-talented motivated biologists with a passion for target discovery and therapeutic advancements.
In this cross-functional project-team leadership role, you will help build the Metabolic Disease therapeutic area (TA) pipeline.Our efforts have focused on high-density multi-modal clinical and cellular datasets for MASLD/Liver fat and Obesity/Adiposity to generate a distinct pipeline of novel targets and/or insights for therapeutic intervention.
Our successful ML-driven target discovery approaches have positioned the group to be sitting on many unique insights which require prosecution as therapeutic targets, towards delivering Drug Candidates and INDs.
Reporting to the VP of Metabolic Disease, his role will primarily be a cross-functional drug discovery project leadership role, focused on rapid development candidate generation from a pool of targets in Metabolic Disease.
This position is onsite and requires you to be in our South San Francisco headquarters five days per week.Your primary responsibilities will be:
You will join a growing biotech startup that has long-term stability due to significant funding, but yet is very much in formation.
You will work with a very accomplished team, learn a broad range of skills, and help shape insitro's culture, strategic direction, and outcomes.
Join us, and help make a difference to patients and find the next generation of therapeuticsAbout You
Our target starting salary for successful US-based applicants for this role is $180,000 - $200,000.
To determine starting pay, we consider multiple job-related factors including a candidate's skills, education and experience, market demand, business needs, and internal parity.
We may also adjust this range in the future based on market data.
This role is eligible for participation in our Annual Performance Bonus Plan (based on company targets by role level and annual company performance) and our Equity Incentive Plan, subject to the terms of those plans and associated policies.
In addition, insitro also provides our employees:
All applicants will be considered for employment without attention to race, color, religion, sex, sexual orientation, gender identity, national origin, veteran or disability status.
We believe diversity, equity, and inclusion need to be at the foundation of our culture.We work hard to bring together diverse teams-grounded in a wide range of expertise and life experiences-and work even harder to ensure those teams thrive in inclusive, growth-oriented environments supported by equitable company and team practices.
All candidates can expect equitable treatment, respect, and fairness throughout the interview process.#LI-Onsite
About insitro
insitro is a drug discovery and development company using machine learning (ML) and data at scale to decode biology for transformative medicines.
At the core of insitro's approach is the convergence of in-house generated multi-modal cellular data and high-content phenotypic human cohort data.
We rely on these data to develop ML-driven, predictive disease models that uncover underlying biologic state and elucidate critical drivers of disease.
These powerful models rely on extensive biological and computational infrastructure and allow insitro to advance novel targets and patient biomarkers, design therapeutics and inform clinical strategy.
insitro is advancing a wholly owned and partnered pipeline of insights and therapeutics in neuroscience, oncology and metabolism.Since launching in 2018, insitro has raised over $700 million from top tech, biotech and crossover investors, and from collaborations with pharmaceutical partners.
For more information on insitro, please visit
Principal Scientist, Metabolic Diseases professionals in San Francisco
-
Natalia Santos
Staff Scientist/ Scientific consultant
-
Sangeetha Kandoi
Stem Cell Biologist with 18+ years of experience.
-
Naikang Kuan
Executive Chef, Principal Food Scientist