- Provide strategic guidance on design and execution of oligo-based drug discovery programs.
- Lead the Oligonucleotide Chemistry Team ensuring the timely delivery of high quality, well characterized material to support oligo programs across the research portfolio.
- Integrate chemistry and delivery strategies in collaboration with the Bioconjugation and Analytical leads to develop and optimize oligonucleotide therapeutics.
- Identify and implement new technologies to enhance drug stability, delivery, and efficacy
- Manage and oversee outsourcing of research grade oligonucleotide synthesis at CROs and coordinate tech transfer to technical operations for GLP/GMP campaigns.
- Regularly review the literature for current advancements with novel nucleic acid chemistries, techniques, and delivery strategies.
- Represent the Oligonucleotide Modality in internal and external scientific meetings.
- Ph.
- Significant hands-on experience in the development of oligonucleotide therapeutics is required.
- Expertise in oligonucleotide chemistry is required
- Knowledge of current advancements in methods oligonucleotide synthetic chemistry and characterization is desired
- Diverse experience with nucleic acid modalities, modification chemistries, and mechanism of action is desired
- A record of accomplishments/publications in relevant scientific discipline
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Associate Director, Oligonucleotide Chemistry Lead - San Rafael, United States - Biomarin Pharmaceutical Inc.
Description
Who We Are
BioMarin is the world leader in delivering therapeutics that provide meaningful advances to patients who live with serious and life-threatening rare genetic diseases.
BioMarin's Research & Development group is responsible for everything from research and discovery to post-market clinical development. Research & Development involves all bench and clinical research and the associated groups that support those endeavors.
Our teams work on developing first-in-class and best-in-class therapeutics that provide meaningful advances to patients who live with rare diseases.
Come join our team and make a meaningful impact on patients' lives.
We are seeking a highly motivated and talented Associate Director to lead the Oligonucleotide Chemistry team within Research at BioMarin Pharmaceutical, Inc.
We are looking for a candidate with extensive experience in oligonucleotide drug discovery to drive the design and development of oligonucleotide-based therapeutics including antisense oligonucleotides and siRNA.
The candidate will work closely with cross-functional partners within the modality and therapeutic areas to develop novel oligonucleotide therapeutic candidates for in vitro and vivo screening, POC, and MOA studies.
Experience in successfully leading the development of multiple oligonucleotide-based modalities and experience with targeted extra-hepatic delivery of nucleic acids is highly desired.
Working knowledge of technical transfer, scale up, and manufacturing is also desired. The candidate must be ready to drive scientific innovation with oligonucleotide-based therapeutics within the research organization at BioMarin.
The candidate will interface with team leads across therapeutic areas including cardiology, neuroscience, musculoskeletal and hematology to advance our most promising research programs for rare genetic diseases.
The candidate will participate effectively in a multidisciplinary team and will lead projects from research through early development to drive effective decision making.
Strong leadership, communication and collaboration skills are essential for this role.This position offers a unique career opportunity to work on an exciting oligo pipeline across multiple therapeutic areas and modalities.
Responsibilities:
Requirements:
in synthetic organic chemistry, oligonucleotide chemistry, chemical biology, or medicinal chemistry, with 6+ years of relevant industry experience in biotech or pharmaceutical companies, is required.
An Equal Opportunity Employer.
All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, or protected veteran status and will not be discriminated against on the basis of disability.
In the U.S., the salary range for this position is $ 150,400 to $ 225,600 per year, which factors in various geographic regions.
The base pay actually offered will take into account internal equity and also may vary depending on the candidate's geographic region, job-related knowledge, skills, and experience among other factors.
A discretionary bonus and/or long-term incentive units may be provided as part of the compensation package, in addition to the full range of medical, financial, and/or other benefits, dependent on the level and position offered.
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