Principal Scientist, Proteomics - La Jolla, United States - Pfizer

Pfizer

Verified Company

La Jolla, United States

4 weeks ago

Posted by:

Mark Lane

beBee recruiter

Description

ROLE SUMMARY

Pfizer's Oncology Research Division is dedicated to the development of oncology agents that disrupt cancer biology or redirect the immune system against cancer cells.

As a Principal Scientist in Proteomics, your research will drive a deeper understanding of ADCs including novel payloads, tumor-associated antigens, and immune engagers.

Relevant proteomic methodologies include label-free and TMT mass spectrometry, and profiling protein abundance, turnover, and interactomes.

You will represent the Systems Biology group on research and drug discovery teams, and will work closely with line leads in biology, chemical biology, drug design, and protein engineering groups to innovate and develop first-in-class oncology therapies.

ROLE RESPONSIBILITIES- Contribute as a proteomics team lead including line leadership within research project teams, developing and deploying new technologies, and manage junior colleagues.- Drive innovation in all aspects of laboratory operations including mass spec technology evaluation, proteomic software evaluation, development of quantitative sample preparation methods and peptide separation methods, data analysis and interpretation.- Enhance the external reputation of Pfizer's Systems Biology through establish research collaborations, presenting at conferences, and contributing publications.

MINIMUM QUALIFICATIONS- Ph.
D.

in biological sciences, proteomics, chemical biology, analytical chemistry, or a related field- 4+ years related industry R&D experience- Experience leading a small team- Applied mass spectrometry-based proteomics experience including experience with Thermo Tribrid Orbitraps.- Expertise with targeted mass spectrometry (parallel reaction monitoring; PRM), data independent acquisition (DIA), and/or tandem mass tag (TMT) methods.- Strong verbal and written communication skills.

PREFERRED QUALIFICATIONS- 6+ years of related industry and/or postdoctoral experience- Experience with ZenoTOF or timsTOF- Deep understanding of automated sample prep, chemoproteomics, targeted biologics, and small-molecule degraders.- Knowledge of oncology including cytotoxins, kinase inhibitors, molecular glues, CD3 bispecifics, and immune-oncology.

Relocation support available

Work Location Assignment:
On Premise

Relocation assistance may be available based on business needs and/or eligibility.
Sunshine Act

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Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act.

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If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.
EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status.

Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA.

Pfizer is an E-Verify employer. This position requires permanent work authorization in the United States.

Research and Development