- Evaluate Life Edit gene editing systems in mammalian cells to identify optimal engineered systems for further therapeutic discovery and development
- Evaluate and troubleshoot protocols for the delivery of Life Edit gene editing systems to different primary cells and cell lines
- Follow current SOPs with an eye towards future improvements
- Support common workflows with the team to maximize efficiencies and progress
- Flexibly communicate and plan support work to enable rapid experimentation
- Analyze experimental data and present scientific results at team research meetings
Requirements: - Senior Associate Scientist: Bachelor's degree in Cell Biology, Biology, Molecular Biology, or a related field with 2+ years of experience or master's degree (0 years experience) in academic or biopharmaceutical organization
- Expertise culturing, transfecting, and analyzing cell lines and primary cells
- Experience delivering nucleic acids or RNA into mammalian cells using multiple delivery methods including nucleofection, lipofection, and lipid nanoparticles
- Experience with modern molecular biology techniques including DNA/RNA extraction, PCR, qPCR, NGS, Flow cytometry and ELISAs
- Experience with molecular cloning techniques including bacterial transformation, nucleic acid purification, and Gibson assembly style cloning
- Comfortable with the execution of computational pipelines with appropriate training
- Experience with laboratory automation and liquid handlers is a plus
- Experience maintaining and organizing ELN documentation
- Demonstrated ability to work independently and collaborate in a team-oriented environment
- Outstanding written and verbal communication skills
- Industry experience strongly preferred
Why join Life Edit and the ElevateBio ecosystem?Life Edit Therapeutics is an integrated subsidiary of ElevateBio, a technology-driven cell and gene therapy company that is accelerating access to the cutting-edge technologies and expertise that can change the future of medicine. Our integrated model combines multiple R&D technology platforms – including Life Edit gene editing – and cGMP manufacturing to power the discovery and development of advanced therapeutics. Our ecosystem is designed to enhance speed, delivery, and probability of success to change patient lives.
Life Edit is an integral part of ElevateBio's ecosystem of platform technologies and is pioneering focused next-generation gene editing technologies and therapeutics. Located in Durham, NC, members of Life Edit work closely with the ElevateBio Research and Development and BaseCamp manufacturing teams in Waltham, MA. Life Edit is advancing therapeutic programs in collaboration with industry partners while building its own internal pipeline of gene editing therapies. We are looking for a unique individual who can continue to lead the cultural development of Life Edit and build on its momentum as an integral part of the ElevateBio ecosystem.
Our Mission:
To power the creation of life-transforming cell and gene therapies, at a speed the world deserves.Our Vision:
We seek to be the world's most indispensable cell and gene therapy technology company, redefining how companies operate, how products are created and how disease is treated.ElevateBio is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, gender, age, religion, national origin, ancestry, disability, veteran status, genetic information, sexual orientation or any characteristic protected under applicable law. ElevateBio will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.
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Senior Associate Scientist, Lead Development - Durham, United States - Life Edit Therapeutics
Description
The Role:
The Lead Development group at Life Edit discovers new genome editing systems and establishes new editing capabilities and optimizes them to support efforts developing curative gene editing therapies and gene edited cell therapies. We are looking for an enthusiastic, competent, and self-motivated Senior Associate Scientist with a strong background in mammalian cell culture and genome editing to help expand our mammalian cell screening efforts.
Here's What You'll Do:
