- Doctorate degree (PhD, ScD and/or MD) in computational biology, statistical genetics, quantitative genomics, bioinformatics or relevant area
- Analytical experience with single-cell RNA-seq, single-cell multi-omics and other NGS-based seq
- Fluency in R/Python/TensorFlow analytic techniques necessary for data analysis
- Experience working with cloud computing environment and data management
- Publication track record in peer-review journals
- Experience in biomedical studies relevant to diseases being investigated including musculoskeletal diseases
- Strong interpersonal, collaborative, organizational, and presentation (oral or written) skills
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Research Fellow
2 weeks ago
Harvard Pilgrim HealthCare Boston, United States Full timeWho We Are · Point32Health is a leading health and wellbeing organization, delivering an ever-better personalized health care experience to everyone in our communities. At Point32Health, we are building on the quality, nonprofit heritage of our founding organizations, Tufts Healt ...
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Research Fellow
4 weeks ago
Harvard Pilgrim HealthCare Boston, United States Full timeWho We Are · Point32Health is a leading health and wellbeing organization, delivering an ever-better personalized health care experience to everyone in our communities. At Point32Health, we are building on the quality, nonprofit heritage of our founding organizations, Tufts Healt ...
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Research Fellow
5 days ago
Mass General Brigham Boston, United States RegularResearch Fellow Description GENERAL SUMMARY/ OVERVIEW STATEMENT: · Our laboratory applies computational, and machine learning methods to understand the impact of seizures and abnormal brain activity on outcomes in critically ill patients with brain injury. Our goal is to improve ...
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Research Fellow
2 weeks ago
Harvard Pilgrim Health Care Institute Boston, United States Full timeWho We Are · Point32Health is a leading health and wellbeing organization, delivering an ever-better personalized health care experience to everyone in our communities. At Point32Health, we are building on the quality, nonprofit heritage of our founding organizations, Tufts Healt ...
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Research Fellow
3 weeks ago
Harvard Pilgrim HealthCare Boston, United States Full timeWho We Are · Point32Health is a leading health and wellbeing organization, delivering an ever-better personalized health care experience to everyone in our communities. At Point32Health, we are building on the quality, nonprofit heritage of our founding organizations, Tufts Healt ...
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Research Fellow BE
2 weeks ago
Mass General Brigham Boston, United States RegularResearch Fellow BE (KPro Description POSITION SUMMARY: Post-doc fellowship in methods for surface modifications of the KPro to improve bio-integration and in delivering gene therapy to the eye. Designs and performs in vitro and in vivo experiments to assess outcomes. · ESSENTI ...
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Research Fellow
3 weeks ago
InsideHigherEd Boston, United StatesJob no: 523287 · Position Type: Staff Full Time · Campus: UMass Boston · Department: SFE - Dean's Office · Date opened: 07 May 2024 Eastern Daylight Time · Applications close: 21 May 2024 Eastern Daylight Time · General Summary: · The Research Fellow would be responsible for cre ...
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Research Fellow BE
2 weeks ago
Massachusetts Eye and Ear Boston, United States Full timePost-doc fellowship in methods for surface modifications of the KPro to improve bio-integration and in delivering gene therapy to the eye. Designs and performs in vitro and in vivo experiments to assess outcomes. ESSENTIAL FUNCTIONS: · Read, analyze and summarize published lit ...
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Research Fellow
2 weeks ago
Mass General Physicians Organization(MGPO) Boston, United StatesGENERAL SUMMARY · The McCance Center for Brain Health in the Department of Neurology at Mass General Hospital is looking for a highly motivated individual with a background in social and behavioral sciences and/or public health to perform cutting-edge research utilizing quantitat ...
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Research Fellow
2 weeks ago
Point32Health Boston, United States**Who We Are** · Point32Health is a leading health and wellbeing organization, delivering an ever-better personalized health care experience to everyone in our communities. At Point32Health, we are building on the quality, nonprofit heritage of our founding organizations, Tufts H ...
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Research Fellow
2 weeks ago
Mass General Physicians Organization(MGPO) Boston, United StatesGENERAL SUMMARY/ OVERVIEW STATEMENT: · The Massachusetts General Hospital ICU Precision Medicine Lab, as part of the MGH Clinical Data Center and the National Patient-Centered CHoRUS for Equitable AI Collaboration, is seeking a Postdoctoral Fellow to participate in ongoing resear ...
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Research Fellow
2 weeks ago
Point32Health Boston, United States**Who We Are** · Point32Health is a leading health and wellbeing organization, delivering an ever-better personalized health care experience to everyone in our communities. At Point32Health, we are building on the quality, nonprofit heritage of our founding organizations, Tufts H ...
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Research Fellow
2 weeks ago
Point32Health Boston, United States**Who We Are** · Point32Health is a leading health and wellbeing organization, delivering an ever-better personalized health care experience to everyone in our communities. At Point32Health, we are building on the quality, nonprofit heritage of our founding organizations, Tufts H ...
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Research Fellow
2 weeks ago
Point32Health Boston, United States**Who We Are** · Point32Health is a leading health and wellbeing organization, delivering an ever-better personalized health care experience to everyone in our communities. At Point32Health, we are building on the quality, nonprofit heritage of our founding organizations, Tufts H ...
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Research Fellow
2 weeks ago
Mass General Physicians Organization(MGPO) Boston, United StatesThe Yonker Laboratory in the Mucosal and Immunology and Biology Research Center (MIBRC) at Massachusetts General Hospital and Harvard Medical School is seeking a highly motivated postdoctoral research fellow. · The Yonker Lab works from bench to bedside to define innate immune ac ...
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Research Fellow
2 weeks ago
Mass General Physicians Organization(MGPO) Boston, United StatesIn the research area of materials for drug and gene delivery, the Center for Systems Biology (CSB) at Massachusetts General Hospital (MGH) seeks applications for postdoctoral fellows interested in new methods for gene and drug delivery. Areas of interest include ultrasound, nanom ...
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Research Fellow
2 weeks ago
Mass General Physicians Organization(MGPO) Boston, United StatesGENERAL SUMMARY/ OVERVIEW STATEMENT: · Our laboratory applies computational, and machine learning methods to understand the impact of seizures and abnormal brain activity on outcomes in critically ill patients with brain injury. Our goal is to improve treatment strategies and the ...
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Research Fellow
2 weeks ago
Harvard University Cambridge, United StatesDetails · Title Research Fellow · School Harvard School of Dental Medicine · Department/Area Kota Lab/Department of Oral Medicine, Infection, and Immunity · Position Description · Kota Laboratory at Harvard School of Dental Medicine is seeking a postdoctoral candidate to stu ...
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Postdoctoral Research Fellow
4 weeks ago
Brigham and Women's Hospital Brookline, United StatesThe Division of Preventive Medicine in the Department of Medicine at the Brigham and Women's Hospital invites applications for a full-time Postdoctoral Research Fellow with expertise in biostatistics, applied machine learning, multi-omics, and epidemiologic cohort analyses. Addit ...
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Postdoctoral Research Fellow
4 weeks ago
Beth Israel Lahey Health Brookline, United StatesWhen you join the growing BILH team, you're not just taking a job, you're making a difference in people's lives. · Job Type: · Regular · Scheduled Hours: · 40 · Work Shift: · Day (United States of America) · Has been awarded or has completed the requirements for a doctoral degree ...
Post-Doctoral Research Fellow - Roslindale, United States - Hebrew Senior Life
Description
Overview
The Marcus Institute for Aging Research is actively seeking a highly qualified and motivated Post-Doctoral Research Fellow and computational biologist with a strong background in NGS-based RNA-seq at single-cell resolution as well as 10X-based single-cell multi-omics data analyses and NGS-based analytical pipelines with innovative statistical and deep-learning modeling to explain skeletal biological mechanisms underlying the observation that the response to drug therapy for osteoporosis wears off over time.
The post-doc will join a Bioinformatics Core recently established via a NIH P50 Center Grant with joint effort from Harvard Medical School, Harvard Dental School, Massachusetts General Hospital, Beth Israel Deaconess Medical Center and the Marcus Institute for Aging Research, Boston, MA.
Bone biopsies from treated patients will be collected before and after treatment of osteoporosis in women who are being seen for osteoporosis at the Massachusetts General Hospital.
10X single-cell multi-omics seq, single-cell and bulk RNA-seq, and proteomics will be measured from both blood and bone biopsy samples.
In addition, mice treated with the same drugs as in the clinical trials will also be conducted and bone biopsies will be collected at different time points during treatment.
The same set of single-cell measurements will be conducted in bone samples collected from treated mice. Cross-species comparison analysis will also be conducted.The successful candidate will have a track record of innovative and collaborative research demonstrated through a strong training program and peer-reviewed publications.
In this vital role, the post-doc will develop and carry out analytical plans and statistical/bioinformatic analyses to study the effects of osteoporosis anabolic therapies on osteoblast progenitors as well as osteocytes in clinical and pre-clinical studies.
Computational analysis on single-cell RNA-seq, bulk RNA-seq and multi-omics seq obtained from post-menopausal women and female mice treated with osteoporosis anabolic therapies (either sclerostin inhibitor or PTH) will be analyzed.
Additional bioinformatic analyses will be conducted to prioritize genes regulating bone formation via existing human genetic variation association analyses; and proposed knockout mice with deeply skeletal phenotypes from collaborators.
The post-doc will interact with skeletal biologists, clinicians, computational biologists, statistical geneticists, and bench scientists at Harvard Medical School, Harvard Dental School, Massachusetts General Hospital, Beth Israel Deaconess Medical Center, the Marcus Institute for Aging Research Boston University and the Broad Institute of MIT and Harvard.
An ability to communicate clearly and collaborate effectively with colleagues from different disciplines will be essential.Required Qualifications
