Jobs
>
Chicago

    Research Scientist II - Chicago, United States - EVOZYNE INC

    EVOZYNE INC
    EVOZYNE INC Chicago, United States

    3 weeks ago

    Default job background
    Description

    Job Description

    Job Description

    Job Summary

    Reporting to the Scientific Program Director, you will drive assay development, protein expression optimization, and high-throughput protein characterization for the discovery of novel protein therapeutics.

    Your primary responsibility is to design and optimize assays for testing the biophysical and biochemical properties of natural and synthetic proteins. You have the expertise and experience in biomolecular structural dynamics to play a significant role on complex and challenging research projects. You'll also be accountable for conducting experiments and analyzing and presenting data to help advance potential assets toward IND. You will collaborate with team members, data scientists, and senior leadership to meet project goals.

    Location: This is an onsite role working in our Chicago office 5 days per week.

    What You'll Do

    • Design assays for testing biophysical and biochemical properties of natural and synthetic proteins, including expression level, solubility, stability, binding/enzymatic activity and inhibition of binding/enzymatic activity.
    • Lead the execution of low-throughput characterization of proteins and high-throughput plate-based/multiplexed screening assays.
    • Optimize protein expression, solubility, purification, and storage as needed for conducting downstream assays.
    • Conduct both high-throughput activity-based screening of large libraries of natural and synthetic protein sequences and low-throughput protein-characterization assays.
    • Collaborate with stakeholders at all levels of the organization to advance project goals.

    Who You Are

    You thrive in an early-stage start-up environment where you can leverage your agility and expertise to deliver high-quality results. You are naturally curious and excel when working collaboratively to solve tough problems. You are a strategic thinker and enjoy being hands-on in the lab. You have a drive for ongoing learning and development. You find satisfaction and motivation from your work, and you take the time to pursue your passions outside of the office.

    Required Skills

    • Demonstrated expertise in biochemistry and biophysics with an emphasis on biomolecular structure and folding and function.
    • Proven experience in protein expression and purification using multiple types of cell lines (bacteria, mammalian, insect, yeast, etc.) and FPLC-based purification platforms such as AKTA or NGC 10.
    • Deep knowledge and direct working expertise in protein stability measuring techniques, binding equilibrium and kinetic measurements, and enzyme kinetics and inhibition assays.
    • Comfortable working with LabChip and automated liquid handling systems such as Tecan or Echo.
    • Familiarity with spectroscopic techniques like fluorescence, plasmonics, raman/resonance raman, EPR, NMR, and FTIR.
    • Proficiency with data-analysis software such as Prism, Origin, and Matlab, and structure-viewing software like PyMOL, Cn3D, Swisspdb viewer, etc.
    • Familiarity with interactive computing platforms like Python, R, and Jupyter.

    Education + Experience:

    • PhD in biochemistry, biophysics, chemical biology or a related area with 4+ years of related experience; may include postdoctoral experience.

    Preferred Skills

    • Biotech and/or pharmaceutical experience strongly preferred.
    • Participation in IND-enabling studies for potential therapeutics.
    • Hands-on experience with at least one of the following biomolecular structure determination techniques like x-ray crystallography, NMR, cryo-electron microscopy, or SAXS.
    • Experience with mass spectrometry techniques such as MALDI, ESI, MS-MS, LC-MS, etc.
    • Exposure to in silico structure prediction and structural dynamics modeling techniques like Rosetta, AlphaFold, VMD, MODELLER, and Foldit.

    Please include a list of your most relevant scientific publications on your resume.

  • NORC

    Research Scientist

    3 weeks ago

    NORC Chicago, United States

    Research Scientist - Support Policy Analysis on Medicare Alternative Payment Models - Remote · Job no: Work type: Regular Full-Time Location: Remote Capability Area: Health Care Evaluation · JOB DESCRIPTION: · NORC at the University of Chicago seeks a qualified Research Scienti ...

  • University of Chicago

    Research Scientist

    2 days ago

    University of Chicago Chicago, United States

    Department · BSD IPP - Administration · About the Department · The newly created Institute for Population and Precision Health (IPPH), located in the Biological Sciences Division, will integrate a wide spectrum of factors such as human health behaviors, environmental factors, soc ...

  • University of Chicago

    Research Data Scientist

    19 hours ago

    University of Chicago Chicago, United States Full time

    Department · EPIC - Climate Impact Lab (CIL) About the Department · As an interdisciplinary research and training center at the University of Chicago, EPIC is contributing innovative solutions to the global energy challenge. Previous results from EPIC projects have been influe ...

  • Metropolitan Water Reclamation District of Greater Chicago

    Environmental Research Scientist

    1 day ago

    Metropolitan Water Reclamation District of Greater Chicago Chicago, United States

    General Statement · Under supervision, carries out applied research projects in relation to wastewater treatment processes, individually or in conjunction with other investigators. Essential Job Functions · Essential job functions are fundamental, core functions common to pos ...

  • Shirley Ryan AbilityLab

    Research Scientist II

    4 weeks ago

    Shirley Ryan AbilityLab Chicago, IL, United States Full time

    By joining our team, you'll be part of our life-changing Mission and Vision. You'll work in a truly inclusive environment where diversity and equity are championed through words and actions. You'll contribute to an innovative culture that is second to none, one that embraces curi ...

  • Fuchs Lubricants

    Research scientist chemistry

    1 week ago

    Fuchs Lubricants Chicago, IL, United States Full time

    Ours is a culture that fosters creativity and empowerment, values work/life balance, and gives you the freedom to excel. With our corporate R&D headquarters and Americas R&D regional hub located in the US, the Research, Development, & Innovaiton Scientist will be working in key r ...

  • Rush Hospital

    Research Scientist II

    3 weeks ago

    Rush Hospital Chicago, United States Full time

    Location: Chicago, IL · Hospital: RUSH University Medical Center · Department: Rush Alzheimers Dis Ctr-ResFac · Work Type: Full Time (Total FTE between 0.9 and 1.0) · Shift: Shift 1 · Work Schedule: 8 Hr (9:00:00 AM - 5:00:00 PM) · Summary: · The Staff Research Scientist ...

  • Metropolitan Water Reclamation District of Greater Chicago

    Senior Environmental Research Scientist

    4 weeks ago

    Metropolitan Water Reclamation District of Greater Chicago Chicago, United States

    General Statement · Under general direction, carries out more complex applied research projects in relation to wastewater treatment processes, individually or in conjunction with other investigators. Work is characterized by greater freedom of action than at the Environmental Re ...

  • Northwestern University

    Senior Research Scientist

    3 weeks ago

    Northwestern University Chicago, United States

    The Department of Otolaryngology-Head and Neck Surgery at Northwestern University Feinberg School of Medicine seeks a full-time tenure track Investigator at the rank of Associate or Full Professor. Responsibilities include establishing hearing research which can effectively partn ...

  • Tempus

    Research Scientist Ii

    1 day ago

    Tempus Chicago, United States

    Passionate about precision medicine and advancing the healthcare industry? · Recent advancements in underlying technology have finally made it possible for AI to impact clinical care in a meaningful way. Tempus' proprietary platform connects an entire ecosystem of real-world evid ...

  • Northwestern University

    Senior Research Scientist

    3 weeks ago

    Northwestern University Chicago, United States

    The Department of Otolaryngology-Head and Neck Surgery at Northwestern University Feinberg School of Medicine seeks a full-time tenure track Investigator at the rank of Associate or Full Professor. Responsibilities include establishing hearing research which can effectively partn ...

  • The University of Chicago

    Research Scientist

    3 weeks ago

    The University of Chicago Chicago, United States

    Department · BSD IPP - Administration · About the Department · The newly created Institute for Population and Precision Health (IPPH), located in the Biological Sciences Division, will integrate a wide spectrum of factors such as human health behaviors, environmental factors, soc ...

  • NORC at the University of Chicago

    Research Scientist

    1 week ago

    NORC at the University of Chicago Chicago, United States

    **JOB SUMMARY**: · NORC at the University of Chicago is seeking a talented Research Scientist to support the Public Health Research Department on suicide prevention and other behavioral health projects. · NORC's Public Health staff work closely with colleagues in Health Sciences ...

  • Ann & Robert H. Lurie Children's Hospital of Chicago

    Research Scientist

    1 day ago

    Ann & Robert H. Lurie Children's Hospital of Chicago Chicago, United States

    Ann & Robert H. Lurie Children's Hospital of Chicago provides superior pediatric care in a setting that offers the latest benefits and innovations in medical technology, research and family-friendly design. As the largest pediatric provider in the region with a 140-year legacy of ...

  • Zoom Video Communications, Inc.

    Research Scientist

    3 weeks ago

    Zoom Video Communications, Inc. Chicago, United States

    **What you can expect** · As a Research Scientist, you will shape Zoom AI's future via groundbreaking research. Enhance AI models, algorithms, and techniques for complex business problems by collaborating with experienced researchers. Fresh graduates can join AI projects, work wi ...

  • University of Chicago

    Cancer Genomics Research Scientist

    3 weeks ago

    University of Chicago Chicago, United States

    Department · BSD PAT - Molecular Pathology · About the Department · Molecular and Cytogenetic Pathology (MCP) at University of Chicago was created to bring together the latest in genomics technologies, computational biology approaches and scientific knowledge for the care of pati ...

  • AbbVie

    Scientist II, Analytical Research

    1 week ago

    AbbVie North Chicago, United States

    Job Description · Job DescriptionCompany Description · AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives acr ...

  • AbbVie

    Scientist II, Analytical Research

    3 days ago

    AbbVie North Chicago, United States

    Job Description · Job DescriptionCompany Description · AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives acr ...

  • AbbVie

    Principal Research Scientist I Chemistry

    2 weeks ago

    AbbVie North Chicago, United States Full time

    Job Description · AbbVie (NYSE:ABBV) is a global, research-based biopharmaceutical company formed in 2013, following separation from Abbott. AbbVie combines the focus and passion of a leading-edge biotech with the expertise and capabilities of a long-established pharmaceutical le ...

  • Northwestern University

    Prosthetic-Orthotic Research Team Scientist

    3 weeks ago

    Northwestern University Chicago, United States

    The Department of Physical Medicine and Rehabilitation at Northwestern University Feinberg School of Medicine seeks a full-time non-tenure-eligible Team Scientist at the rank of Assistant Professor or Associate Professor for research and education opportunities at the Northwester ...