- Advance Small Molecule pharmaceutical project portfolio through application of cADME modelling tools and DMPK principles.
- Research, implement and apply methods to identify the need and guide the design of in vitro and in vivo experiments.
- Lead research efforts to understand connectivity of in silico model predictions to in vitro and in vivo experimental ADMET data.
- Conceptualize approaches, identify capability gaps, and set goals within small molecule ADMET modeling and drug design
- Own the implementation and deployment of production quality computational ADMET models.
- Represent Small Molecule ADMET CDD on cross-functional research teams
- Prepare and present research in top-leading journals or conferences.
- Maintain a well-documented, reusable codebase, and traceable model history
- Maintain scientific and technical expertise through familiarity with scientific literature and attending conferences
- Work closely with Therapeutic areas, Research Chemistry and Computational Drug Discovery to drive discovery and development efforts
- Work with ML scientists and engineers to guide the development of our ML model infrastructure.
- Collaborate with colleagues from ADME, Tox, Computational Drug Discovery and ML to implement production quality global and local predictive models.
- Actively participate in virtual global team meetings regularly
- Participate in the evaluation of external and internal capabilities and facilitate collaborations with external partners
- Present results to interdisciplinary teams of experimental, modeling scientists and machine learning colleagues at company meetings. Physical Requirements Up to 10% overnight travel required. Qualifications
- Ph.D. with 8+ years of relevant experience can be considered (or M.Sc. with 10+ years required). Degree in Cheminformatics, Computational Chemistry, Computational Biology or related quantitative field preferred
- Relevant experience includes:
- Research experience in the field of small molecule drug discovery within industry or academia (industry preferred)
- Solid understanding of DMPK principles
- Proven track record of knowledge and use of ADMET modeling and cheminformatics methods and tools
- Experience with QSAR/QSPR modeling, machine learning, and AI methods.
- Experience in scripting or programming languages such as Python and workflowing methods.
- Hands on experience with at least one major cheminformatics toolkit and artificial intelligence/machine learning platform (e.g. RDKit, PyTorch, Scikit-learn).
- Ability to perform in-depth data analysis and develop algorithms to solve complex problems.
- Excellent written and oral communication skills
- Detail oriented with strong documentation skills
- Familiarity with popular commercial in silico ADMET platforms
- Familiarity and working experience with a breadth of tasks of the Design-Make-Test-Analyze drug discovery cycle – highly preferred We commit to an inclusive recruitment process and equality of opportunity for all our job applicants. At Novo Nordisk we recognize that it is no longer good enough to aspire to be the best company in the world. We need to aspire to be the best company for the world and we know that this is only possible with talented employees with diverse perspectives, backgrounds and cultures. We are therefore committed to creating an inclusive culture that celebrates the diversity of our employees, the patients we serve and communities we operate in. Together, we're life changing. Novo Nordisk is an equal opportunity employer. Qualified applicants will receive consideration for employment without regard to race, ethnicity, color, religion, sex, gender identity, sexual orientation, national origin, disability, protected veteran status or any other characteristic protected by local, state or federal laws, rules or regulations. If you are interested in applying to Novo Nordisk and need special assistance or an accommodation to apply, please call us at This contact is for accommodation requests only and cannot be used to inquire about the status of applications.
-
Principal Scientist
1 week ago
Novo Nordisk A/S Lexington, United StatesThe Principal Scientist will, through external innovation, provide scientific leadership in the identification and validation of new drug targets, advancing novel therapies and developing technologies to accelerate drug research. This will be achieve Scientist, Diabetes, External ...
-
Principal Scientist
7 hours ago
Novo Nordisk A/S Lexington, United StatesOur US Research & Development (R&D) hub, located in the Greater Boston area, brings together the best talent to drive life science innovation, from early research through late-stage clinical development. By combining the speed and agility of biotech Drug, Scientist, Principal, Gl ...
-
Principal Scientist
1 week ago
BioSpace Lexington, United StatesJob Details · About the Department · As part of the establishment of our R&D Hub in greater Boston, Novo Nordisk is growing its efforts within advanced drug delivery. A cornerstone of this is an expansion of our efforts in advancing oral biologics-based treatments to address unme ...
-
Principal Scientist
3 weeks ago
Novo Nordisk Lexington, United States Full timeAbout the Department · Global Drug Discovery (GDD) is engaged in accelerating the path of novel cardiometabolic therapies for clinical development within Novo Nordisk. A main focus is discovery and evaluation of novel targets that can modulate cardiometabolic disease and advance ...
-
Principal Scientist
7 hours ago
BioSpace Lexington, United StatesJob Details · About the Department · Global Drug Discovery (GDD) is engaged in accelerating the path of novel cardiometabolic therapies for clinical development within Novo Nordisk. A main focus is discovery and evaluation of novel targets that can modulate cardiometabolic disea ...
-
Principal Scientist
1 week ago
BioSpace Lexington, United StatesJob Details · About the Department · Our US Research & Development (R&D) hub, located in the Greater Boston area, brings together the best talent to drive life science innovation, from early research through late-stage clinical development. By combining the speed and agility of ...
-
Principal Scientist
1 week ago
Novo Nordisk A/S Lexington, United StatesAbout the Department · Our US Research & Development (R&D) hub, located in the Greater Boston area, brings together the best talent to drive life science innovation, from early research through late-stage clinical development. By combining the speed and agility of biotech with ...
-
Principal Scientist
3 weeks ago
Novo Nordisk Lexington, United States Full timeAbout the Department · Our US Research & Development (R&D) hub, located in the Greater Boston area, brings together the best talent to drive life science innovation, from early research through late-stage clinical development. By combining the speed and agility of biotech with t ...
-
Principal Machine Learning Scientist
23 hours ago
Xometry Lexington, United StatesJob Description · Job DescriptionXometry (NASDAQ: XMTR) powers the industries of today and tomorrow by connecting the people with big ideas to the manufacturers who can bring them to life. Xometry's digital marketplace gives manufacturers the critical resources they need to grow ...
-
Senior Data Scientist
1 week ago
Xometry Lexington, United StatesXometry (NASDAQ: XMTR) powers the industries of today and tomorrow by connecting the people with big ideas to the manufacturers who can bring them to life. Xometry's digital marketplace gives manufacturers the critical resources they need to grow their business while also making ...
-
Senior Data Scientist
22 hours ago
Xometry Lexington, United StatesJob Description · Job DescriptionXometry (NASDAQ: XMTR) powers the industries of today and tomorrow by connecting the people with big ideas to the manufacturers who can bring them to life. Xometry's digital marketplace gives manufacturers the critical resources they need to grow ...
-
Head of Chemistry
23 hours ago
Orum Therapeutics Lexington, United StatesJob Description · Job DescriptionSalary: · We are seeking an experienced Head of Bioconjugation/Chemistry to join our dynamic technology platform team. As a key leader, you will play a pivotal role in advancing our efforts in the discovery and development of cutting-edge oncolog ...
-
Business Development/Project Delivery Leader
1 week ago
HDR Lexington, United StatesAbout Us · At HDR, we specialize in engineering, architecture, environmental and construction services. While we are most well-known for adding beauty and structure to communities through high-performance buildings and smart infrastructure, we provide much more than that. We cre ...
-
Business Development/Project Delivery Leader
1 week ago
hdr Lexington, United States Full timeBusiness Development/Project Delivery Leader Description About Us · At HDR, we specialize in engineering, architecture, environmental and construction services. While we are most well-known for adding beauty and structure to communities through high-performance buildings and s ...
-
FAST Labs
2 weeks ago
BAE Systems Lexington, United States Full timeJob Description Looking to make a difference developing disruptive technologies? BAE Systems FAST LabsTM leads the way with opportunities for tackling the Defense and Intelligence Communities' hardest problems with innovative software and hardware solutions. FAST Labs, the resear ...
-
Field Engagement
6 days ago
Pacific Institute for Research and Evaluation Frankfort, United StatesJob Title · Field Engagement - Program Coordinator · Shift Type · Education · Bachelor's Degree · Location · Kentucky US Counties: Perry Breathitt, Knott, Leslie, Letcher, Boyd, Greenup, and Carter - US (Primary) · Career Level · Experienced (Non-Manager) · Category · R ...
-
Director, Formulations Development
1 week ago
Adare Pharma Solutions Frankfort, United StatesAre you ready to join a growing, global drug development and manufacturing organization that puts people first? · Come to Adare · We work closely with our pharmaceutical industry partners during all phases of drug development and commercial manufacturing with a mission of impro ...
-
Principal Consultant
6 days ago
Haley & Aldrich Frankfort, United StatesAt · Haley & Aldrich , a 900+ person national engineering and environmental consulting firm, our creative, technically strong staff work collaboratively to deliver exceptional value to clients. We look for professionals with a passion for solving complex challenges and for creat ...
-
Kion Group AG Frankfort, KY, United StatesAt Dematic, we are gearing up to revolutionize our data landscape by building a cutting-edge Enterprise Data Lakehouse Platform. We are forming two pivotal platform teams that will spearhead the creation of the platform's foundational components. These teams go beyond traditional ...
-
Environmental Engineer
2 weeks ago
U.S. Army Joint Munitions Command Richmond, United StatesSummary Please limit your resume to 5 pages. If more than 5 pages are submitted, only the first 5 pages will be reviewed to determine your eligibility/qualifications. About the Position: This position is located at the Blue Grass Army Depot, in Richmond Kentucky. If you are a cur ...
Principal Scientist - Lexington, United States - Novo Nordisk
Description
About the Department
Computational Drug Design (CDD) is the Novo Nordisk organization where we develop and apply state of the art capabilities in data science, predictive modeling, and AI/ML to enable both ligand and structure-based drug design. Scientists within CDD collaborate seamlessly with teams across the globe to invent better molecules faster. With an unbiased approach to drug modalities, in-house access to the newest screening techniques, and world-class experimentation, we have a wealth of opportunities to impact our pipeline and save and improve patient lives. We work in multidisciplinary, highly collaborative discovery teams both locally and across Novo Nordisk's global network to invent novel medicines by applying advanced computational techniques and developing innovative computational methods. We engage in external collaborations to ensure access to innovative research and technology. Small Molecule Digital Chemistry is dedicated to the research and development of small molecule therapeutics. Our role is two-fold: support cutting-edge pharmaceutical research projects and develop innovative computational technologies in digital chemistry field. To be successful, we foster strong collaborations with Small Molecule Medicinal Chemistry within our Global Research and Technology (GRT) organization and colleagues across the Data Science and Innovation (DSI) organization. Our mission is to deliver in silico models, cheminformatics tools and computational chemistry platforms to enable in silico small molecule drug design to benefit patients across the globe. We believe in the value of a diverse and inclusive culture. Together, we build and grow talent to ensure the development of novel solutions. The team is comprised of collaborative, diverse and passionate people who have a true sense of pride in their work. We are committed to helping each other grow, and we are driven by the opportunity to make a difference in the lives of people living with chronic disease. Everything we do starts and ends with the patient. And, while changing the future of chronic disease treatment, such as diabetes and obesity, is no easy task, we also recognize the importance of an enjoyable workplace, which is why we have cultivated a culture of fun, ingenuity, and innovation. Our competitive compensation package and support of a healthy work-life balance all add to a best-in-class employee experience. The Position The Senior/Principal Data Scientist – Computational Absorption, Distribution, Metabolism, and Excretion (cADME) will contribute to the Small Molecule Digital Chemistry team's effort towards improved understanding of ADMET biological endpoints through research and development of in silico models. The Senior/Principal Data Scientist – cADME will have knowledge and experience in ADME data analysis and modeling, advanced computational modeling methods and small molecule project support. They will have working knowledge of common ADME data and tools and a high degree of proficiency in AI/ML predictive modeling using machine learning, cheminformatics, and HPC/cloud computing. They will be able to implement complex workflows to aggregate and prepare experimental data, generate predictive ML/AI models, execute virtual screening, and perform multi-objective optimization of small molecules. The Senior/Principal Data Scientist - cADME will champion an in-silico first mindset and show initiative in recognizing and addressing unmet scientific needs using internal and external data. Relationships This role reports to the Senior Scientific Director of SMDC. They will have close interactions with scientists and experts within Computational Drug Discovery, Medicinal Chemistry, Quantitative Biology and ADME & Tox. Additional internal partners include data scientists, data engineers, ML specialists, software developers and others across US, UK, and Denmark. External relationships include commercial and academic collaboration partners. Essential Functions
