Associate Scientist I, Conjugation Development - San Carlos, United States - Vaxcyte

Vaxcyte

Verified Company

San Carlos, United States

2 weeks ago

Posted by:

Mark Lane

beBee recruiter

Description

Join our Mission to Protect Humankind

Vaxcyte is a clinical-stage vaccine innovation company engineering high-fidelity vaccines to protect humankind from the consequences of bacterial diseases, which have serious and costly health consequences when left unchecked.

Working to eradicate or treat bacterial infections such as invasive pneumococcal disease, Group A Strep, periodontitis and Shigella is just the beginning.

Our path to success is clear and well-defined, and Vaxcyte is set up to go the distance.

WHAT we do is every bit as important as
HOW we do it Our work together is guided by four enduring core values:

AIM HIGH: We embody our collectively audacious goal to courageously make the most complex biologics ever attempted to protect humankind.
LEAD WITH HEART: Everyone leads at Vaxcyte with a kindness first, inclusive approach to collaboration and vigorous debate that advances our business objectives.
RETHINK CONVENTION: We bring creative and intellectual diversity to every facet of the work we do in order to innovate and re innovate the way vaccines are delivered.
MODEL EXCELLENCE: The magnitude of our challenge requires our shared commitment to demonstrating integrity, accountability, equality and clarity across communications and decision making.

Summary:

Essential Functions:

Optimize and troubleshoot multistep synthesis of proteinpolysaccharide conjugates.
Analyze conjugates with several methods including colorimetric assays and multiple HPLC assays.
Purify conjugates using a variety of methods including sizeexclusion chromatography and tangential flow filtration (TFF).
Contribute to the development and execution of Design of Experiment (DoE) models for process development.
Support the development work toward a process characterization of conjugate vaccine.
Complete any assigned tasks in high quality and in a timely manner.
Maintain good documentation practices for recording experimental plans and results in electronic lab notebook and associated reports.
Assist in troubleshooting of instrumentation and test methods, including the ordering of supplies and maintenance of equipment.
Participate in group meetings, present results of work, interpret data, and report results in an accurate manner.
Work within a team environment and provide support to further team objectives.

Requirements:

BS or MS Degree in Chemistry, Biochemistry or related discipline with 02 years of industrial experience.
Experience in setting up and carrying out chemical reactions. Experience with protein conjugation reactions is a major plus.
Experience with laboratoryscale protein purification methods such as dialysis, diafiltration, sizeexclusion chromatography, and tangential flow filtration (TFF).
Hands on experience with analytical methods including reversedphase HPLC, colorimetric assays, sizeexclusion chromatography (SEC), and SDS-PAGE for characterization of reaction products.
Direct experience operating Agilent HPLC using OpenLab/ Chemstation software and/ or Waters UPLC and Empower software for data acquisition and analysis is a plus.
Highly organized, strong attention to details and excellent record keeping/documentation abilities.
Critical thinking and ability to analyze data.
Eager and able to learn and understand new concepts.
Strong interpersonal skills and ability to communicate effectively with team members.
Ability to work under supervision and collaborate effectively with team members.
Committed to upholding high standards of integrity, professionalism, and safety in all aspects of work.
All Vaxcyte employees require vaccination against COVID19.

Reports to:
Scientist I, Conjugation Development

Location:
San Carlos, CA

Compensation:

The compensation package will be competitive and includes comprehensive benefits and an equity component.

Salary Range:
$74,000 - $88,000

Send resumes to:

Vaxcyte, Inc.

825 Industrial Road, Suite 300

San Carlos, CA 94070

We are an equal opportunity employer.

All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or veteran status.