Scientist 3 - Beltsville, United States - NextCure Inc

Description

NextCure is a clinical-stage biopharmaceutical company located in Beltsville, MD, focused on the discovery and development of first-in-class immunomedicines for the treatment of cancer and other diseases We are committed to professional development in the context of learning, managing, and developing our employees.

We create a unique environment for our employees, providing exposure to various facets of our operations cultivating career growth and development.

• Design and execute cell culture and/or protein purification studies at bench and pilot scale to develop bioprocessing steps for monoclonal antibodies and other complex biologics.
• Design experiments, analyze and evaluate data and make sound conclusions based on scientific principles and statistical methodologies.
• Establish appropriate setpoints and ranges leading to robust and repeatable process performance.
• Support pilot and clinical manufacturing as needed.
• Challenge current paradigm to significantly improve cell culture productivity, process yield and efficiency through implementation of new technologies, optimization of platforms and improved raw materials.
• Operate automated and semiautomated small and pilotscale bioreactors and protein purification systems.
• Utilize highthroughput cell culture and purification equipment such as ambr15, ambr250, and Tecan liquid handlers.
• Perform process scaleup to pilot or clinical manufacturing scale equipment using engineering principles.
• Perform inprocess analytical testing using Nova, cell counters, Solo VPE, Octet and other technologies.
• Perform simple product quantity and quality analyses using technologies such as HPLC and UV/VIS spectrophotometers.
• Working in teams, plan and schedule studies, develop timelines and create raw material usage plans.
• Document laboratory data and experimental results in laboratory notebooks on an everyday basis.
• Write technical reports, verify data, and present experimental results in departmental or crossfunctional meetings.
• Follow good documentation practices, safety requirements and all department and company policies.

• 24 years of handson experience with process development studies using bench or pilot scale bioreactors, chromatography systems and filtration equipment.
• Experience with mammalian cell culture systems and/or purification of antibodies or biologics.
• Experience with operation and maintenance of inprocess analytics such as Nova, cell counters, ELISA plate readers, HPLC systems, SOLO VPE, Octet or other relevant technologies.
• Experience of authoring technical reports, brief technical presentations and conference posters and abstracts.
• Experience of design of experiments, simple statistical analysis and data interpretation.

• 4 or more years of experience in process development studies using bench or pilot scale bioreactors, chromatography systems and filtration equipment.
• Experience in GMP manufacturing of biopharmaceuticals.
• Knowledge and experience demonstrated by scientific accomplishments with high productivity cell lines, cell culture systems or highly innovative protein purification strategies.
• Knowledge of assay development and execution.
• Experience with use of engineering principles to perform process scaleup.
• Experience of media and/or feed optimization to significantly increase cell culture productivity.

• Bachelor's degree in the life sciences, chemical or biochemical engineering or related field required.
• Master's or higher degree in the life sciences, chemical or biochemical engineering or related field preferred.
• 4 years industry experience with process development studies using bench or pilot scale bioreactors, chromatography systems and filtration equipment.
• NextCure, Inc. is committed to equal opportunity and affirmative action in employment. The company ensures nondiscrimination in all its employment practices. Every qualified applicant is considered for employment without attention to race, color, religion, sex, national origin, political affiliation, sexual orientation, gender identity, marital status, disability, status as a protected veteran, genetic information, age, or any other characteristic protected by law._