- Design, implement and evaluate methodologies for structure-based protein design.
- Collaborate with pre-clinical team to design and optimize molecules to achieve therapeutic program aims.
- Collaborate with platform scientists to define and generate training and validation data for optimal method development.
- Maintain up to date on state-of-the-art macromolecular modeling and ML advances.
- Ph.D. in Computational Biology, Bioengineering, Computer Science or a related field. Post-graduate experience is a plus.
- Experience with macromolecular modeling, docking and protein design. Experience with Rosetta is highly preferred. Experience in Molecular Dynamics is a plus.
- Experience with modeling and design of antibodies or antibody-like molecules.
- Experience with state-of-the-art protein design deep learning tools, such as AlphaFold2, RoseTTAFold, RFdiffusion, etc.
- Experience developing machine learning models in the context of protein design or protein property prediction.
- Familiarity with modern deep learning architectures such as Diffusion models, Transformers, Graph Neural Networks, Flow-based models, etc.
- Mastery of python and pytorch.
- Experience with git, docker, cloud computing, and software development best practices. Experience with ML experiment tracking, model registries and workflow orchestration tools such as Nextflow is a plus.
- Excellent communication, organizational and problem-solving skills.
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2024 Co-Op, Computational Protein Design
1 month ago
Moderna, Inc. Cambridge, United States Full timeThe Role: · The Computational Protein Engineering and Modeling team at Moderna is seeking a co-op in Computational Sciences to support our research and discovery efforts from July-December. You will learn first-hand about mRNA therapeutics and gain valuable experiences of what it ...
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Protein Engineer
5 days ago
Source Bio, Inc Cambridge, United StatesAPPLY FOR THIS JOB HERE: · Protein Engineer · At Source Bio, we are working on novel AAV gene therapy technologies – making AAV gene therapy safer, cheaper, and better for everyone. It is a big mission, and we are looking for talented, ambitious, optimistic people to join our te ...
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Scientist, Protein Sciences
5 days ago
Third Rock Ventures Cambridge, United StatesScientist/Sr. Scientist – Protein Sciences · A stealth mode Third Rock Ventures start up is seeking a dynamic and motivated Protein Scientist to become an integral part of the Discovery Biologics group. The successful candidate will spearhead the build-out of the Protein Sciences ...
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Bench Scientist
5 days ago
eTeam Cambridge, United StatesJob Title: Bench Scientist · Location: Cambridge, MA · Duration: 18 months · Role Summary: · BioMedicine Design (BMD) is seeking a highly motivated biochemist to join Biotherapeutic Expression and Purification group (BEP) in Cambridge, MA. Qualified candidate will play a unique a ...
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Scientist
5 days ago
Net2Source Inc. Cambridge, United StatesPlease find below the job description:- · Title- Bench Scientist · Location- Cambridge, MA · Duration- 18 months Contract · Payrate: $32- $34/HR on w2 without benefits · Job Description: Primary responsibilities include: · Client BioMedicine Design (BMD) is seeking a highly mot ...
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Postdoctoral Position in Biophysics
3 weeks ago
Harvard University Cambridge, United StatesDepartment/Area · Physics Department Position Description Physics Department at Harvard University invites applications for a postdoctoral position in the field of biophysics, biochemistry and biology. The successful applicant will work in Prof. Mara Prentiss' group at Harvard ...
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Scientist
3 days ago
AcousticaBio Cambridge, United StatesScientist, Formulation/Drug Delivery | Advanced Manufacturing in Life Science · Summary: AcousticaBio is proud to announce this unique opportunity to join our company as Scientist, Formulation/Drug Delivery. AcousticaBio is an innovative deep-tech startup; we're a venture and NIH ...
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Associate Scientist, Biology
2 weeks ago
The Steely Group Cambridge, United StatesYou will have the opportunity to contribute to an early drug discovery program in the Targeted Protein Degradation space. This position offers the unique opportunity to directly impact a growing portfolio of targeted therapies in a fast-paced and innovative research environment. ...
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Principal Scientist, Translational Discovery
2 weeks ago
Bristol Myers Squibb Cambridge, United States Full timeWorking with Us · Challenging. Meaningful. Life-changing. Those aren't words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production li ...
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Associate Research Scientist
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Net2Source Inc. Cambridge, United StatesNet2Source Inc. is an award-winning total workforce solutions company recognized by Staffing Industry Analysts for our accelerated growth of 300% in the last 3 years with over 5500+ employees globally, with over 30+ locations in the US and global operations in 32 countries. We be ...
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Biomarker Scientist
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QurAlis Cambridge, United StatesABOUT THE COMPANY · At QurAlis, we are neuro pioneers on a quest to cure. We work with a relentless pursuit of knowledge, a precise attention to craft, and an optimistic mindset to discover and develop effective precision medicines that will alter the trajectory of amyotrophic l ...
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Research Associate, Molecular
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Flagship Pioneering Cambridge, United StatesAbout Alltrna · Alltrna, a Flagship-founded company, has mapped tRNA biology to systematically design tRNA medicines and encode a completely new, unifying approach to treating both rare and common human diseases driven by shared genetic mutations. Our mission is to unlock tRNA b ...
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Senior Scientist, Discovery Biology
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Senior Research Associate, Cell
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Associate Research Scientist
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Senior Scientist
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Senior Research Associate
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Discovery Scientist
5 days ago
QurAlis Cambridge, United StatesABOUT THE COMPANY · At QurAlis, we are neuro pioneers on a quest to cure. We work with a relentless pursuit of knowledge, a precise attention to craft, and an optimistic mindset to discover and develop effective precision medicines that will alter the trajectory of amyotrophic l ...
Scientist, Computational Protein Design - Cambridge, United States - Flagship Pioneering
Description
Company Summary:
Founded by Flagship Pioneering in 2021, Metaphore aims to unlock breakthroughs that outperform today's drugs for maximum patient impact, We adapted this idea to drug discovery. MIMICTM, our computationally driven bioplatform that couples machine learning with molecular mimicry, engineers therapeutics to trigger a desired biological response. Our MIMIC platform opens the possibility to develop engineered medicines with specific features to access a range of targets, including those that were previously intractable. Flagship and Metaphore have also just announced a $600M research collaboration with Novo Nordisk to develop up to two next-generation therapeutics for obesity management.
Metaphore Biotechnologies is a product of Flagship Pioneering's venture creation engine, which has also given rise to companies such as Moderna Therapeutics (NASDAQ: MRNA), Editas Medicine (NASDAQ: EDIT), Omega Therapeutics (NASDAQ: OMGA), Seres Therapeutics (NASDAQ: MCRB), and Indigo Agriculture. Since its launch in 2000, Flagship has applied its unique hypothesis-driven innovation process to originate and foster more than 100 scientific ventures. In 2021, Flagship Pioneering was ranked 12th globally on Fortune's "Change the World" list, an annual ranking of companies that have made a positive social and environmental impact through activities that are part of their core business strategies.
Position Summary:
Metaphore Biotechnologies is seeking an enthusiastic Computational Protein Design and Machine Learning Scientist to join our computation-guided therapeutic discovery and development engine. In this role, you will work at the interface of physics-based and machine learning-based protein design to develop and deploy state-of-the-art approaches to challenging therapeutic biomolecule discovery and optimization goals. As a member of the modeling team, you will have the opportunity to be a key contributor on a variety of tasks, including de novo design, multi-parameter optimization, inverse folding, sequence-structure-function modeling and more. You will work closely with Metaphore's preclinical and platform teams to both develop molecules and delineate the ideal training and validation data for method development. The ideal candidate will bring experience in molecular modeling of proteins and protein complexes, structure-based design tools, and state-of-the-art deep learning approaches, helping us unlock the potential of molecular mimicry for therapeutics development. This individual will have the opportunity to join a dynamic interdisciplinary team and also be part of the Flagship ecosystem of companies, providing unique networking benefits through regular meetups, collaboration, and an environment of development and discussion around new ideas shaping the fields of computational biology, ML/AI and data-driven drug discovery.
Key Responsibilities:
Qualifications:
At Flagship, we recognize there is no perfect candidate. If you have some of the experience listed above but not all, please apply anyway. Experience comes in many forms, skills are transferable, and passion goes a long way. We are dedicated to building diverse and inclusive teams and look forward to learning more about your unique background.
Recruitment & Staffing Agencies : Flagship Pioneering and its affiliated Flagship Lab companies (collectively, "FSP") do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering's internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto.
Scientist, Computational Protein Design professionals in Cambridge
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Cole Paulin
Electrical Engineering and Computer Science