Scientist Ii, Dmpk - Ridgefield, United States - BI Pharmaceuticals, Inc.

BI Pharmaceuticals, Inc.
BI Pharmaceuticals, Inc.
Verified Company
Ridgefield, United States

3 weeks ago

Mark Lane

Posted by:

Mark Lane

beBee recruiter
Description

Boehringer Ingelheim is seeking an enthusiastic, creative, and highly motivated Scientist II to join the Viral Platforms Group in Drug Metabolism & Pharmacokinetics (DMPK) Department at our US headquarters in Ridgefield, CT.

The main responsibility of this position is to develop the assays (cell-based, ligand binding-based, PCR-based) used for evaluating PK and immunogenicity of viral vectors in a non-clinical and clinical setting.


As an employee of Boehringer Ingelheim, you will actively contribute to the discovery, development and delivery of our products to our patients and customers.

Our global presence provides opportunity for all employees to collaborate internationally, offering visibility and opportunity to directly contribute to the companies ́ success.

We realize that our strength and competitive advantage lie with our people.

We support our employees in a number of ways to foster a healthy working environment, meaningful work, diversity and inclusion, mobility, networking and work-life balance.

Our competitive compensation and benefit programs reflect Boehringer Ingelheim ́s high regard for our employees.


Duties & Responsibilities:


  • Design/develop/perform PCRbased assays (qPCR, qRTPCR, SLqPCR, and/or digital PCR) to detect viralvector based drugs and quantify their level in biological samples.
  • Design/develop/perform cell
- based and ligand binding-based assays to detect antibodies against viral-vector based drugs.

  • Design/develop/perform exploratory studies in vivo (primarily mice).
  • Operate and maintain lab equipment; initiate and complete routine procedures in an independent and efficient manner; troubleshoot effectively and solve scientific problems.
  • Serve as scientific monitor for assay performance at external CROs.
  • Effectively communicate and defend own work in the context of team and department goals, both orally and in writing.
  • Coauthor protocols and procedures.
  • Report and treat data with a high level of integrity and ethics; author/contribute to protocols, procedures, and technical reports; make scientific presentations internally and externally.
  • Comply with applicable regulations; perform all work in a safe manner; maintain proper records in accordance with SOPs and policies.

Requirements:


  • Bachelor ́s Degree with 3+ years experience in Immunology, Virology, Biochemistry or similar; or Master ́s Degree in Immunology, Virology, Biochemistry or similar; or equivalent experience in related field
  • Demonstrated expertise in developing one or more of the following: in vitro cellbased assays, ligand bindingbased immunoassays, PCRbased assays.
  • Demonstrates an appropriate level of understanding of immunology and viral vectors (e.g. VSV, AAV, HIV).
  • Proficient in cell culture.
  • Hands on experience performing routine animal procedures (e.g. mouse tailvein injection/ tissue collection) is a plus.
  • Hands on experience in ELISA, multiple assay platforms (Envision, Spectramax, MSD etc), flow cytometry experience is a plus.
  • Hands on experience with validation of bioanalytical methods for biologics in a regulatory environment (GLP/GCP) is desirable.
  • Ability to operate laboratory equipment independently.
  • Proven problemsolving ability.
  • Excellent oral and written communication skills.
  • Be a team player in a dynamic environment.

Compensation Data:


Eligibility Requirements:


  • Must be legally authorized to work in the United States without restriction.
  • Must be willing to take a drug test and postoffer physical (if required)
  • Must be 18 years of age or older
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