- Drive performance by leading team members in the design and synthesis of low dose drug candidates and the development of stage-appropriate progression funnels for their identification
- Develop and execute a strategy in alignment with functional goals and key scientific objectives across discovery research and within the Calico aging and oncology portfolio
- Maintain appropriate resourcing and budget projections in partnership with the Abbvie-Calico Project management team
- As programs advance, develop plans to address and reduce risks in collaboration with key stakeholders to help successfully drive towards candidate nomination
- Manage project activities and professional development of a team of scientists through effective mentoring, guidance, and supervision
- Advance scientific expertise within the function and collaborate with cross-disciplinary teams to advance programs from research to development
- Ensure the quality and effectiveness of key project results through sound medicinal chemistry design, early risk assessments, and implementation of fallback strategies
- Provide expert advice and share knowledge with direct reports, peers, and senior management
- Provide guidance to develop both the skills and the careers of direct reports.
- Train and mentor functional colleagues and assess current and emerging business challenges to achieve functional goals
- Identify and integrate emerging scientific trends from internal and external sources into functional objectives
- Present program updates and research strategies to functional and non-functional leaders as well as potential and existing partners
- Maintain awareness of emerging literature and science in the field and author scientific disclosures/publications
- Maintain scientific presence outside AbbVie with appropriate publication and conference abstract submission highlighting innovative medicinal chemistry learnings
Qualifications
Qualifications: - BS, MS, or PhD in organic chemistry or medicinal chemistry or equivalent field with 10+ years (PhD), 16+ years (MS) or 18+ years (BS) of related work experience in biotech or pharma
- Proven track record of driving early to late-stage discovery programs
- Extensive knowledge and experience in modern medicinal chemistry
- Highly organized and self-directed, experience leading multiple complex simultaneous research programs
- Excellent written and verbal communication is required as well as critical evaluation and data-driven decision making
- Highly collaborative, team-oriented, and considerate of the needs of others
- Strong interpersonal skills and ability to collaborate with diverse groups within the organization and external partners
- Experience evaluating internal and external research and development programs
- Project director experience within the Calico collaboration within the aging and oncology portfolios
- Proven team leadership and management abilities, including experience mentoring, guiding, supervising, and developing scientific personnel with various backgrounds and training levels
- Ability to create an inclusive environment where diverse ideas, viewpoints and backgrounds are valued; willingness and ability to lead inclusively and demonstrate a commitment to listen and consider all points of view
Additional Information
Applicable only to applicants applying to a position in any location with pay disclosure requirements under state or local law: - The compensation range described below is the range of possible base pay compensation that the Company believesingood faith it will pay for this role at the time of this posting based on the job grade for this position.Individualcompensation paid within this range will depend on many factors including geographic location, and we mayultimatelypay more or less than the posted range. This range may be modified in the future.
- We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick),medical/dental/visioninsurance and 401(k) to eligible employees.
- This job is eligible to participate in our short-term incentive programs.
- This job is eligible to participate in our long-term incentive programs. Note: No amount of payis considered to bewages or compensation until such amount is earned, vested, anddeterminable.The amount and availability of any bonus, commission, incentive, benefits, or any other form of compensationand benefitsthat are allocable to a particular employee remains in the Company's sole and absolute discretion unless anduntil paid andmay be modified at the Companys sole and absolute discretion, consistent with applicable law. AbbVie is committed to operating with integrity, driving innovation, transforming lives, serving our community and embracing diversity and inclusion. It is AbbVies policy to employ qualified persons of the greatest ability without discrimination against any employee or applicant for employment because of race, color, religion, national origin, age, sex (including pregnancy), physical or mental disability, medical condition, genetic information, gender identity or expression, sexual orientation, marital status, status as a protected veteran, or any other legally protected group status.
Senior Principal Scientist, Medicinal Chemistry - North Chicago, United States - AbbVie
Description
Company Description
AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas immunology, oncology, neuroscience, and eye care and products and services in our Allergan Aesthetics portfolio. For more information about AbbVie, please visit us Follow @abbvie onTwitter,Facebook,Instagram,YouTubeandLinkedIn.
Job Description
Small Molecular Therapeutics and Platform Technologies (SMTPT) within Discovery Research seeks an accomplished scientist to lead a team of medicinal chemists within the Global Medicinal Chemistry (GMEC) organization. GMEC is committed to delivering first and best-in-class small molecules in conventional and unconventional drug-like space with the potential to improve human health. The Senior Principal Research Scientist will lead a team of chemists designing and synthesizing small molecules aimed at identifying and advancing promising low dose leads (responsibility for lead generation through candidate nomination).
She/He/They will be responsible for managing a diverse team of scientists who design and synthesize drug candidates for novel targets throughout AbbVies drug discovery pipeline including pipeline projects partnered with Calico Life Sciences. She/He/They may serve as Project Director for some/all of these efforts. The team will develop novel medicinal chemistry strategies and execute multiparametric optimization(s) of drug candidate properties in a highly collaborative environment aimed at accelerating the delivery of a sustainable pipeline of first in class/breakthrough small molecule drug candidates with transformative potential.
The candidate will have experience with project conception, strategic planning, and project leadership as well as contributing to cross-functional and matrixed teams within the Calico collaboration and the AbbVie therapeutic areas. The candidate will have a strong expertise in modern medicinal chemistry, including an appreciation of modern computational and experimental tools, multidisciplinary inputs, and synthetic technologies needed to develop low dose small molecule drug candidates. The ideal candidate will have a strong and established background in drug discovery and a proven track record of successfully leading diverse project teams and matrix teams to produce novel drug candidates. The candidate will be able to lead by influence in a matrix environment and maintain a productive, collaborative, and inclusive environment. Strong communication skills are essential as the candidate must be able to tailor interactions with technical teams and represent the program and strategy to executive-level management both within AbbVie and the joint AbbVie-Calico executive leadership team.
Key Responsibilities: