Postdoctoral Research Scientist Position in Bioinformatics - New York City, United States - Columbia University Institute for Cancer Genetics

Description

Postdoctoral Research Scientist Position in Bioinformatics

A Postdoctoral position in Bioinformatics is available in the laboratory of Dr. Zhiguo Zhang at the Institute for Cancer Genetics, located in the Columbia University Irving Medical Center. We are interested in epigenetic inheritance and cancer epigenetics. We are generating a large amount of omic-based data including RNA-Seq, CUT&RUN, eSPAN, and MeDIP-Seq, and genome-wide CRISPR-Cas9 screens to address questions related to epigenetic inheritance and cancer epigenetics. We are seeking a highly motivated scientist with a strong background in Bioinformatic analysis who will analyze epigenomic datasets generated in the laboratory, generate novel hypotheses via data analysis, and collaborate with other fellows in the laboratory to complete projects in a timely manner.

Zhang Lab and Research information can be found at: https://zgzhanglab-

To apply for this position, please go to:

Interested candidates should email their CV and names of three references to:

部分发表论文列表:

1. Li Z, Duan S, Hua X, Xu X, Li Y, Menolfi D, Zhou H, Lu C, Zha S, Goff S, Zhang Z. Asymmetric distribution of parental H3K9me3 in S phase silences L1 elements Nature, 623:643–651.

2. Xu X, Duan S, Hua X, Li Z, He R, and Zhang Z. Stable inheritance of H3.3-containing nucleosomes during mitotic cell divisions Nature Communications, 13:2514.

3. Mo Y, Duan S, Zhang X, Hua X, Zhou H, Wei HJ, Watanabe J, McQuillan N, Su Z, Gu W, Wu CC, Vakoc CR, Hashizume R, Chang K and Zhang Z. Epigenome programing by H3.3K27M mutation creates a dependence of pediatric glioma on SMARCA Cancer Discovery, 12:2906–2929.

4. Yu, C., Gan, H., Serra-Cardona, A., Zhang, L., Gan, S., Sharma, S., Johansson, E., Chabes, A., Xu, R.M., Zhang, Z. A mechanism for preventing asymmetric histone segregation onto replicating DNA strands Science, 361:1386–1389.

5. Zhang, L., Serra-Cardona, A., Zhou, H., Wang, M., Yang, N., Zhang, Z.* and Xu, R.* Multisite substrate recognition in Asf1-dependent acetylation of histone H3K56 by Rtt Cell, 174(4):818–830

6. Fang D, Gan H, Lee J, Han J, Wang Z, Riester SM, Jin L, Chen J, Zhou H, Wang J, Zhang H, Yang N, Bradley EW, Ho TH, Rubin BP, Bridge JA, Thibodeau SN, Ordog T, Chen Y, van Wijnen AJ, Oliveira AM, Xu R, Westendorf JJ, Zhang Z The histone H3.3K36M mutation reprograms the epigenome of chondroblastomas. Science, 352:1344–1348.

Columbia University is an equal opportunity employer / disability / veteran.