- Design and execute synthetic strategies to access complex target molecules (a strong organic synthesis background is essential)
- Demonstrate critical thinking skills and creativity to overcome challenging synthetic chemistry problems
- Learn and implement medicinal chemistry strategies that enable discovery of novel, differentiated small molecule candidates for tumor targeted delivery programs
- Analyze structural, pharmacological, physicochemical and ADMET data to derive SAR
- Employ structure and property-based design principles to generate innovative new target designs
- Work independently and as a team player who collaborates closely with colleagues from diverse drug discovery functions, including computational chemistry and high throughput experimentation
- Regularly attend, present and participate in group meetings
- Contribute to the writing of patent applications, program reports and peer reviewed publications
- Work safely in accordance with safety, health & environment (SHE) best practices
- Doctoral degree (Ph.
- Subject matter expert in organic synthesis and methodology, with general knowledge of the mechanisms of chemical reactivity and awareness of latest scientific literature.
- Strong work ethic and adherence to safe practices in the laboratory.
sr. scientist, medicinal chemistry, ttd, early oncology - Waltham, MA, United States - AstraZeneca PLC
![Default job background](https://contents.bebee.com/public/img/bg-user-ex-1.jpg)
Description
Sr. Scientist, Medicinal Chemistry, TTD, Early OncologyLocation:
Waltham, MA, US
Do you want to be at the cutting edge of innovation that will lead to state-of-the-art therapies for cancer? At AstraZeneca, we turn ideas into life changing medicines.
This Opportunity
The newly hired Sr. Scientist will contribute to and influence small molecule ligand discovery within the tumor targeted delivery (TTD) chemistry group.
This role is part of an important strategy to deliver highly specific therapeutics including, small molecule, peptide and antibody drug/prodrug/degrader conjugates with various targeting modalities to treat cancer.
The job posting is for our group at Boston/Waltham location.Core Accountabilities:
Essential Requirements:
D.) or equivalent focused in synthetic organic chemistry or medicinal chemistry with 0-3 years of experience in academia, biotech and/or pharmaceutical industry setting ((OR M.Sc.
degree focused in synthetic organic chemistry with 5+ years of industry experience), with a strong track record of scientific innovation and success documented through peer-reviewed publicationsThe Waltham R&D site is home to our small-molecule oncology research in North America. It is situated within a biopharma cluster of academic research institutions, medical centers, pharmaceutical companies and biotech start-ups. The Boston region is consistently ranked #1 globally for biotech research, investment, talent recruitment and lab space.
The campus, also known as the Boston BioHub, is one of the largest and most dynamic life-science research hubs in the region.
The site is also home to the AstraZeneca Incubator, a program that helps emerging companies advance novel and innovative healthcare solutions to meet the needs of patients.
Plenty of free covered/uncovered parking is available along with charging stations for electric vehicles. Additionally, shuttle service to local transportation hubs is also available.
As AstraZeneca continues to put patients at the forefront of our mission, we are excited for our move to Kendall Square/Cambridge in 2026.
Find out more information here:
Kendall Square Press Release
Why AstraZeneca?
At AstraZeneca, we are dedicated to being a Great Place to Work. A place where employees are empowered to push the boundaries of science and unleash their entrepreneurial spirit. There is no better place to make a difference to medicine, patients, and society. An inclusive culture that champions diversity and collaboration. Always committed to lifelong learning, growth, and development.
So, what is next?
A place built on courage, curiosity, and collaboration - we make bold decisions driven by patient outcomes.
Empowered to lead at every level, free to ask questions and take calculated risks that write the next chapter for our pipeline.
If you are swift to action, confident to lead, willing to collaborate, and passionate about the possibilities, then we are keen to hear from you
When we put unexpected teams in the same room, we unleash bold thinking with the power to inspire life-changing medicines.
Date Posted
29-Apr-2024
Closing Date
05-May-2024Our mission is to build an inclusive and equitable environment. We want people to feel they belong at AstraZeneca and Alexion, starting with our recruitment process. We welcome and consider applications from all qualified candidates, regardless of characteristics. We offer reasonable adjustments/accommodations to help all candidates to perform at their best. If you have a need for any adjustments/accommodations, please complete the section in the application form.
AstraZeneca requires all US employees to be fully vaccinated for COVID-19 but will consider requests for reasonable accommodations as required by applicable law.