Computational Scientist for SMaHT Project - Cambridge, MA

Only for registered members Cambridge, MA, United States

3 weeks ago

Job summary

The Somatic Mosaicism across Human Tissues (SMaHT) Network was established by the NIH to catalog somatic genetic variation across human tissues and discover its patterns causes and consequences.
This effort includes all classes of somatic mutation single nucleotide variants short insertions and deletions structural variants and other large chromosomal aberrations. The somatic mutation catalog will enable downstream analyses such as rates and burdens of mutations across tissues mutational signature analysis driver mutations and clonal expansions and lineage tracing.

Responsibilities

Design execute data QC and analysis strategies involving multimodal human tissue datasets.
Apply develop state-of-the-art computational tools pipelines to a) assess data quality b) integrate diverse data types metadata c) detect somatic mutations subsequent downstream analyses.

Job description

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