Medicinal Chemistry Scientist II/ III - Rockville - Frederick National Laboratory

Description

Medicinal Chemistry Scientist II/III
Job Summary:
The Frederick National Laboratory is seeking a skilled Medicinal Chemistry Scientist to support the development of therapeutic candidates and lead compounds. The selected candidate will provide technical expertise in medicinal chemistry, working closely with the DDD program leadership to implement research and development practices.

Responsibilities:
• Provide support for medicinal chemistry of therapeutic candidates and promising lead compounds with NCATS APP program
• Support the Antiviral Program for Pandemics (APP) initiatives by providing technical support for the design, synthesis, purification, analytical characterization, and biological evaluation of bioactive compounds
• Assist in the design, synthesis, purification, and characterization of bioactive compounds with techniques such as column chromatography, high performance liquid chromatography, nuclear magnetic resonance, and parallel or combinatorial synthesis
• Design new bioactive compounds by interacting with other chemists regarding biochemical, molecular biochemical, and pharmacological topics
• Provide technical expertise in the implementation and execution of chemistry design and synthesis improvements
• Evaluate the structure-activity relationships of compounds
• Review and analyze data from diverse in vitro assays and ADME, PK, and efficacy studies
• Summarize data and prepare reports for individual or sets of compounds
• Design, implement, execute assigned projects with minimal supervision
• Prepare documentation associated with project/objectives including technical reports, SOPs, project-specific protocols, and reports
• Prepare manuscripts and scientific presentations
• Ensure laboratory procedures and testing are compliant with internal requirements and quality system
• Work with automated systems, such as robotics, system integration, and software programming
• Analyze data and present findings at meetings
• Anticipate obstacles and implement solutions
• Perform review of project-specific documents
• Ensure appropriate communication strategies and plans are in place to facilitate and maintain communication among scientific, regulatory, safety, monitoring, laboratory, and project team members

BASIC QUALIFICATIONS
To be considered for this position, you must minimally meet the knowledge, skills, and abilities listed below:
• Possession of a PhD degree in a field related to organic/medicinal chemistry from an accredited college or university according to the Council for Higher Education Accreditation (CHEA). Foreign degrees must be evaluated for equivalency.
• In addition to the education requirement, a minimum of two (2) years of progressively responsible relevant experience for the Medicinal Chemistry Scientist II role or five (5) years of progressively responsible relevant experience for the Medicinal Chemistry Scientist III role
• Experience and training relevant to conduct the design, synthesis, purification, and characterization of bioactive compounds and evaluate new bioactive compounds regarding biochemical, molecular biochemical, and pharmacological topics
• Excellent written and oral communication skills, including strong report writing and presentation skills
• Strong interpersonal and cross-cultural communication skills
• Experience in analysis, planning, and problem solving
• Strong organizational skills with the ability to prioritize and manage multiple tasks with a high degree of accuracy and attention to detail
• Ability to work effectively, both independently and as a team member, with consistent ability to take initiative and make an active contribution to the team's performance
• Demonstrated proficiency in Windows and Microsoft Office Suite, including Word, Excel, Project, and Outlook
• Ability to obtain and maintain a security clearance