- Designing and implementing clear synthetic strategies towards complex molecules using innovative synthetic methodologies.
- Maintaining high efficiency in the laboratory setting to produce target molecules for SAR development.
- Implementing multiple parameter optimization strategy to advance SAR by applying medicinal chemistry knowledge and understanding of ADME, pharmacokinetics, optimal physicochemical properties, and AI/ML prediction tools.
- Collaborating with structure-based design group to influence the rational design of new molecules.
- Effectively communicating medicinal chemistry strategies, innovative ideas, and biological results in departmental and project meetings.
- Collaboratively supporting the advancement of compounds through in vitro and in vivo studies to identify development candidates.
- Ph.D. degree in organic or medicinal chemistry required, postdoc and/or 1-3 years of industrial experience preferred. A MS degree in organic/medicinal Chemistry and a minimum of 8 years of experience will be considered.
- Experience in NMR spectroscopy, x-ray crystallography, or cryo-EM would be a plus
- Strong track record of achievement in the synthesis of complex molecules and/or synthetic methodology development, with deep knowledge of modern synthetic & analytical techniques.
- Proven track record of scientific contributions including peer reviewed publications, patents, and presentations.
- Independent thinking and the ability to effectively collaborate in a highly matrixed environment.
- Excellent oral and written communication skills, including preparation of presentations.
-
Senior Medicinal Chemist
1 week ago
Newton Colmore Boston, United States· Newton Colmore is working with a dynamic drug discovery company dedicated to developing novel therapeutics to address unmet medical needs. They leverage cutting-edge technologies and a collaborative approach to drive advancements in drug discovery and improve patient outcomes. ...
-
Scientist, Medicinal Chemistry
1 week ago
Jnana Therapeutics Boston, United StatesAbout Us · Jnana Therapeutics is a clinical-stage biotechnology company leveraging its next-generation RAPID chemoproteomics platform to discover medicines for highly validated, challenging-to-drug targets to treat diseases with high unmet needs. Jnana is focused on developing fi ...
-
Boston University Boston, United StatesThe Department of Pathology and Laboratory Medicine at Boston University Chobanian & Avedisian School of Medicine (BUCASM) and Boston Medical Center (BMC) is seeking to hire a faculty member at the Assistant Professor level. The successful candidate Chemistry, Clinical, Director, ...
-
Boston University BOSTON, United StatesThis is an ideal opportunity for an experienced research technician seeking an exciting new position in a disease-relevant area that would allow them to expand their array of laboratory skills, as well as a person seeking a period of research experie Chemistry, Technician, Resear ...
-
BioSpace Boston, United StatesJob Details · At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees around the world work to discover and bring life-changing medicines to those who need th ...
-
Senior Director Medicinal Chemistry
1 week ago
Vertex Pharmaceuticals, Inc Boston, United StatesJob Description · General Summary: · We are seeking an accomplished and innovative scientist to lead a drug discovery team within the medicinal chemistry group at the Boston research site. This individual will lead, motivate, and develop a team of approximately 10-15 highly skill ...
-
Tufts Medicine Boston, United StatesWere saving lives, building careers, and reimagining healthcare. We cant wait to grow alongside you. · The Department of Pathology and Laboratory Medicine of Tufts Medical Center, Tufts Medicine, is seeking a full-time Medical Director of the Core Laboratory. The Core laboratory ...
-
Medical Technologist, Chemistry Lab
1 week ago
K.A. Recruiting Boston, United StatesMedical Technologist/ MLS or Medical Laboratory Technician CHEMISTRY Opening at one of MA's Top Healthcare Providers This organization is looking to add a permanent and full time Medical Technologist/ Medical Laboratory Technician to their team on e Medical Technologist, Chemistr ...
-
Tufts Medicine Boston, United StatesWe're saving lives, building careers, and reimagining healthcare. We can't wait to grow alongside you.The Department of Pathology and Laboratory Medicine of Tufts Medical Center, Tufts Medicine, is seeking a full-time Medical Director of the Core Laboratory. The Core laboratory f ...
-
Research Engineer 2
1 week ago
Brigham and Women's Hospital Boston, United StatesJob Description - Research Engineer · We are seeking a Research Engineer II, in the Traverso Lab at Brigham and Women's Hospital with a background in analytical chemistry. Our research group consists of an interdisciplinary team of engineers, chemists, biologists, pharmaceutical ...
-
Vertex Pharmaceuticals, Inc Boston, United StatesJob Description · General Summary: · The Analytical and Purification Principal Research Associate will lead the small molecule chiral purification platform within the Medicinal Chemistry group. The individual will propose and develop improvements in the purification workflow alon ...
-
Chemist
1 week ago
Mirus Consulting Group Boston, United Statesmirus Consulting Group is a local company based in Humacao, Puerto Rico that provides computer system validation and information technology consulting services to pharmaceutical companies and other organizations across the Island and parts of the United States. Its services inclu ...
-
Computational Chemist
3 days ago
Kojin Therapeutics Boston, United StatesThe ideal candidate will have a strong, demonstrated track-record of applying computational chemistry to accelerate drug-discovery processes, as well as excellent cross-disciplinary communication skills. The candidate should enjoy working in multi-disciplinary teams comprised of ...
-
Kojin Therapeutics Boston, United StatesWe are seeking highly motivated, skilled, and collaborative scientists to join our growing biology team. The ideal candidates will be proficient in molecular and cellular biological skills and have a passion for contributing to drug discovery. Applicants with expertise in chemica ...
-
BioSpace Boston, United StatesJob Details · At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees around the world work to discover and bring life-changing medicines to those who need th ...
-
Scientific Software Developer
2 weeks ago
PostEra Boston, United States[Full Time] Scientific Software Developer at PostEra (United States) | BEAMSTART Jobs · Scientific Software Developer · PostEra United States · Date Posted · 31 Oct, 2022 · Work Location · Boston, United States · Salary Offered · $120000 — $160000 yearly · Job Type · Full Time ...
-
Bioanalytical Chemist
4 days ago
Kojin Therapeutics Boston, United StatesWe are seeking a highly motivated and experienced bioanalytical chemist focused on mass spectroscopy to join our PK, metabolism, and biomarker discovery group. This group focuses on liquid chromatography-mass spectrometry (LC-MS) based quantitation of small molecule drugs and met ...
-
Research Engineer 2
6 days ago
Brigham & Women's Hospital(BWH) Boston, United StatesWe are seeking a Research Engineer II, in the Traverso Lab at Brigham and Women's Hospital with a background in analytical chemistry. Our research group consists of an interdisciplinary team of engineers, chemists, biologists, pharmaceutical scientists, and physicians focused on ...
-
Engineering Lead
1 week ago
1910genetics Boston, United StatesEngineering Lead - Manager / · Director/VP · Computation is revolutionizing drug discovery. Advances in bigchemical data, massive computing power, artificial intelligence, andmolecular dynamics simulation are changing the way we develop newdrugs. At 1910 Genetics, we put comput ...
-
Associate Director
1 week ago
Lifelancer Boston, United StatesAbout the job Associate Director / Director AI Cheminformatics · Associate Director or Director, Cheminformatics · Cambridge, Massachusetts · Onsite, 1 day a week remote working · Generative AI, Drug Discovery, Pharmaceutical, Machine Learning, Artificial Intelligence · KEMI ...
Medicinal/Organic Chemists - Boston, United States - Kojin Therapeutics
1 week ago
Description
The ideal candidates will have a deep understanding of organic reaction mechanisms, proficient organic chemistry lab skills, and a strong ability to design synthetic routes to complex molecules. Applicants with experience in small-molecule drug discovery will be given priority. The candidates should enjoy working in a multi-disciplinary team comprised of medicinal chemists, enzymologists, molecular, cell, and chemical biologists, pharmacologists and DMPK experts working on the development of novel therapeutics.
The best candidates for this role will have demonstrated success in these responsibilities:
The best candidates for this role will have the following qualifications:
About Us
Kojin Therapeutics, Inc. is harnessing groundbreaking discoveries in cell-state and ferroptosis biology to develop first-in-class, oral treatments for use in patients with various forms of cancer, as well as cardiovascular, immunologic, hepatic, and degenerative diseases. Named after the Japanese deity that tamed fire for the good of humanity, Kojin is located in Boston's Seaport biotech neighborhood. We have developed a drug-discovery platform that integrates computational chemistry, structural biology, chemical biology, target-informed screening, and mechanism-driven pharmacology to develop small-molecule therapeutics that specifically modulate ferroptosis -- a newly discovered form of programmed cell death. Kojin is backed by a strong syndicate of top-tier investors, led by an experienced biotechnology and pharmaceutical-industry leadership team, and driven by creative dedicated professionals.
We accept submission of CVs directly from candidates but not from any third-party recruitment or staffing agencies.