- Ph. D. with 5+ years or a Masters degree with 10+ years of NMR experience in small and/or large molecule structure elucidation.
- Experience with the state-of-the-art NMR instrumentation in order to provide key information for projects at all stages of pharmaceutical discovery and development.
- Experience in NMR spectroscopy and structure elucidation; demonstrated ability to apply 1D, 2D and heteronuclear NMR techniques specifically to the structural elucidation of small molecules (e.g., impurities/degradants/metabolites) and/or large molecules (e.g., oligonucleotides, proteins, monoclonal antibodies).
- Educated and trained in Pharmaceutical or Chemical Sciences
- Demonstrated expertise in modern NMR pulse sequence programming and AU/macro programming on Bruker spectrometers.
- Experience in structure elucidation software (e.g. ACD) for NMR.
- Expertise in automated sample preparation, acquisition, and data analysis.
- Demonstrated ability to utilize NMR techniques to characterize oligonucleotides, proteins, and monoclonal antibodies.
- Knowledge of closely related scientific disciplines as they apply to drug discovery and development (e.g., solid-state NMR, mass spectrometry, vibrational spectroscopy, XRPD).
- Demonstrated ability to integrate spectroscopic and other scientific data into the processes of structure elucidation.
- Demonstrated ability to deliver this scientific knowledge within and beyond their scientific discipline.
- Flexible thinking and demonstrated ability to innovate in creating options and solutions required in solving challenging problems.
- Experience with the overall drug development process, including GxP requirements.
- Demonstrated excellence in both oral and written communication.
- Demonstrated ability to proactively build networks and relationships that instill confidence, trust, and teamwork.
- Demonstrated knowledge and application of Digital, Data and Analytics principles, tools, and approaches.
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Investigator - Collegeville, United States - GlaxoSmithKline
Description
Site Name: USA - Pennsylvania - Upper ProvidencePosted Date: May
We currently have a vacancy on our team for an NMR spectroscopist focusing on small molecule structure elucidation. This is an exciting opportunity for an enthusiastic individual to join an NMR-focused team within a multi-disciplinary analytical department, delivering expert solution-state NMR support to a range of projects from early discovery through late-stage development. Applications in small molecules, oligonucleotides, protein therapeutics and drug products will all form part of this exciting role.
Working in a flexible NMR team, the successful candidate will undertake NMR analyses, including structure elucidation, conformational analysis, mixture analysis and more, supporting problem solving and product development from multiple projects with diverse challenges. The successful candidate will also work alongside other multi-faceted scientists as part of cross-functional project teams and will work with a high level of autonomy and accountability, contributing to regulatory submissions and overseeing the completion of work packages to deadlines.
Has a role under guidance of the Team Leader to :
• Provide knowledge and expertise in NMR, structure elucidation and reaction mechanisms to support the discovery and development of drug candidates
• Provide expertise, knowledge and strategic vision to enhance and expand NMR experimental approaches in structure elucidation including tailored approaches to meet the specific needs of stakeholders.
• Provide technical and scientific creativity in resolving non-routine issues associated with structure identification studies
• Serve as a mentor to team in developing scientific expertise
• Troubleshoot experimental and instrumental issues
• Comply with the requirements of Quality, Safety and GSK policies and procedures and ensure that GSK intellectual property is protected.
Further expectations :
• Contribute to and effectively work within matrix teams comprised of colleagues from both within and outside of their own department
• Self-motivated flexible approach with good organizational skills and ability to communicate in a scientific manner.
• Evaluate potential innovative research areas and/or apply innovative solutions to projects.
• Successful record of influencing, mentoring and developing colleagues.
• Contribute to regulatory dossiers and author/review expert reports
Why you?
Basic Qualifications:
We are looking for professionals with these required skills to achieve our goals:
Preferred Qualifications:
If you have the following characteristics, it would be a plus:
#LI-GSK
Please visit GSK US Benefits Summary t o learn more about the comprehensive benefits program GSK offers US employees.
Why GSK?
Uniting science, technology and talent to get ahead of disease together.
GSK is a global biopharma company with a special purpose - to unite science, technology and talent to get ahead of disease together - so we can positively impact the health of billions of people and deliver stronger, more sustainable shareholder returns - as an organisation where people can thrive. We prevent and treat disease with vaccines, specialty and general medicines. We focus on the science of the immune system and the use of new platform and data technologies, investing in four core therapeutic areas (infectious diseases, HIV, respiratory/ immunology and oncology).
Our success absolutely depends on our people. While getting ahead of disease together is about our ambition for patients and shareholders, it's also about making GSK a place where people can thrive. We want GSK to be a place where people feel inspired, encouraged and challenged to be the best they can be. A place where they can be themselves - feeling welcome, valued, and included. Where they can keep growing and look after their wellbeing. So, if you share our ambition, join us at this exciting moment in our journey to get Ahead Together.
If you require an accommodation or other assistance to apply for a job at GSK, please contact the GSK Service Centre at US Toll Free) or outside US).
GSK is an Equal Opportunity Employer and, in the US, we adhere to Affirmative Action principles. This ensures that all qualified applicants will receive equal consideration for employment without regard to race, color, national origin, religion, sex, pregnancy, marital status, sexual orientation, gender identity/expression, age, disability, genetic information, military service, covered/protected veteran status or any other federal, state or local protected class.
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