- In partnership with senior discovery and development leadership, set the DMPK strategy and plans for Odyssey's small molecule research and development portfolio
- Establish and oversee activities at CROs, including in vitro ADME, PK, bioanalysis and PK/PD modeling
- Build DMPK capabilities, externally and internally
- Be the functional area representative for DMPK on project teams, collaborating closely with medicinal chemistry and biology/pharmacology
- Design, analyze and interpret preclinical DMPK studies in support of program goals and objectives
- Use a broad array of DMPK data to enable integrated analyses of biopharmaceutics, drug metabolism, PK/PD, human PK/dose projections and risk of drug-drug interactions
- Author and review study reports and relevant sections of regulatory documents
- An advanced degree, such as MS with 15+ years of experience or PhD. with 10+ years of experience, with a focus in pharmacokinetics, pharmacology or related discipline
- Proactive at solving complex problems within a collaborative, multidisciplinary team environment
- Technical depth and a broad understanding of small molecule DMPK, with experience from early discovery through to IND
- Extensive experience optimizing and characterizing the ADME properties of small molecule drug candidates, supported by a strong publication record in DMPK sciences. Expertise in the interplay between DMPK parameters, physicochemical and molecular properties
- Proficient in the management of activities at CROs and comfortable working in virtual outsourced model.
- Expertise in PK/PD modeling from discovery through early development; proficient with Phoenix WinNonlin or similar
- Experience leading DMPK on projects particularly in discovery and early development
- Operational experience and familiarity with the drug discovery and development process, including external regulatory requirements
- Outstanding oral and written communication, and organizational skills; comfortable navigating complexity and ambiguity in a fast-paced environment interacting with consultants, external vendors, and internal cross-functional, global project teams
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Sr / Director DMPK - Boston, United States - Odyssey Therapeutics
Description
About Us
Odyssey Therapeutics is propelling drug development beyond what is now possible to deliver medicines that address critical needs of patients with inflammatory diseases and cancer. We achieve unprecedented speed and efficiency by bringing together a target-centric approach, a toolbox of cutting-edge technologies, and a team of accomplished, world-class drug hunters. By reimagining the drug development process, we are creating a deep and broad drug pipeline that holds the potential to transform human health.
Position Details
Job Title: Sr/Director DMPK
Location: Boston, MA
Employment Type: Full-Time
Department: Non-Clinical Development
The Opportunity
The Sr/Director drug metabolism-pharmacokinetics (DMPK) will oversee the company's DMPK function and will play a key role in the discovery and advancement of Odyssey's small molecule therapeutic portfolio. This role will serve as the function head, applying subject matter expertise in absorption, distribution, metabolism, and excretion (ADME), pharmacokinetics (PK), and pharmacodynamics to drive the strategy and execution of our pre-clinical programs. The candidate will be expected to collaborate cross functionally to develop and implement studies vital to address key program DMPK issues and successfully advance pre-clinical compounds into development.
Key Responsibilities
About You
