Scientist – Medicinal Chemistry - Monrovia, United States - Terray Therapeutics

Description

Company Overview

Terray is a biotechnology company with the technology, data, and mindset to radically change the way we discover and develop small molecule therapeutics. We explore molecules and targets broadly and deeply with a sophisticated integration of ultra-high throughput experimentation, generative AI, biology, medicinal chemistry, automation, and nanotechnology. Everything the company does is grounded in an iterative approach, producing massive amounts of precise, purpose-built data mapping interactions between small molecules and causes of disease that gets increasingly valuable with each cycle of design and experimentation. The company's platform uniquely blends experimentation and computation to improve the cost, speed, and success rate of small molecule drug discovery and development.

Position Summary

Terray is currently seeking a motivated and creative scientist to join our growing medicinal chemistry group. As an integral member of the Preclinical Development team, the candidate will contribute to hit-to- lead and lead optimization efforts across multiple programs, leveraging our vast chemical datasets and proprietary wet-lab + computational platforms to power state-of-the-art small molecule design and synthesis. In this interdisciplinary role, the candidate will work closely with the data science and biology functions at Terray, as well as the machine learning, computational chemistry, DMPK and Pharmacology teams within Terray.

The core responsibilities of this position are:

• Synthesis and design of small molecules from multiple programs in hit-to-lead and lead optimization
• Partner with the computational and platform teams to design compounds for on- and off-platform synthesis
• Work closely with CRO chemists to design synthetic routes and trouble-shoot problematic syntheses
• Apply physical organic chemistry principles to guide SAR, molecular design and target binding
• Learn medicinal chemistry principles to guide multiparameter optimization of ADME, DMPK and safety
  properties

Experience and Qualifications

Part of Terray's success is nurtured by a hands-on work environment where everyone is accountable, vested in a vision of excellence, and actively taking part in the success of the business. Terray supports a positive work environment where employees can feel engaged, recognized and empowered to be creative.

Required Qualifications:

• Ph.D. or postdoc in organic chemistry, synthetic chemistry or related field
• 0-2+ years of postdoctoral experience in synthetic chemistry, catalysis, reaction methodology
• Can demonstrate scientific initiative and creativity in multi-step synthesis and/or reaction methodology through primary authored, peer-reviewed publications
• Demonstrates high proficiency in purification methods and in principles of physical organic chemistry
• Formulates conclusions of scientific experiments clearly and can design follow-on experiments
• Demonstrates high productivity in the lab while showcasing a high degree of autonomy
• Adheres to good safety practices
• Reliable and dependable scientist with strong presentation and communication skills
• Excellent organizational and interpersonal skills and can thrive in a highly cooperative, fast-paced environment

Compensation Details

$104,000-$156,000 (annually) depending on seniority; participation in the Company's option plan; 3% 401K contribution; full benefits

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