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    Scientist, PhD - Stanford, CA, United States - Stanford University

    Stanford University
    Stanford University Stanford, CA, United States

    2 weeks ago

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    Description

    The Laboratories of Casey Gifford (Depts of Genetics and Pediatrics) and Jesse Engreit (Dept of Genetics) are seeking a Research Scientist (Life Science Research Professional 3) focusing on human and mouse genetics, genome editing, and genomics to lead a project to understand the genetic basis of congenital heart defects.

    The Gifford and Engreitz Laboratories are located in the Biomedical Innovations Building on the main campus at Stanford University and are members of the BASE Initiative in the Betty Irene Moore Children's Heart Center, a collaboration with Drs.


    Project overview:

    DNA regulatory elements in the human genome, which harbor thousands of genetic risk variants for common and rare heart diseases and could reveal targets for therapeutics that aim to precisely tune cellular functions — if only we could map the complex regulatory wiring that connects 2 million regulatory elements with 21,000 genes in thousands of cell types in the human body.

    We have recently developed new approaches that could enable mapping this regulatory wiring at massive scale (see Fulco et al. Science 2016, Fulco et al.

    Nature 2021), and applied these and other approaches to understand the genetic basis of congenital heart defects (Gifford et al.

    Science 2019, Schricker et al.

    We have now identified enhancers that contain disease variants that affect risk for congenital heart defects, and aim to study the functions of these enhancers in mouse models and human cardiac organoids.

    These studies will ultimately help to uncover biological mechanisms of congenital heart defects, and help to guide diagnosis and treatment for children with heart disease.

    We are looking for creative and passionate people at any stage in their career (see other job postings).

    The Gifford and Engreitz Laboratories are located adjacent to one another and provide a dynamic, interdisciplinary workplace with unique access to cutting edge technologies and scientific thought, with the potential for widespread recognition of scientific contributions.

    We value a diversity of values, backgrounds, and approaches to solving problems.

    The candidate for this position should have hands-on experience in mouse genetics, molecular biology, genomics, and cellular assay development; experience with quantitative data analysis; curiosity in research and creativity in problem-solving; experience building or managing teams; and have a passion for science and sense of urgency to find new medicines to benefit patients.


    In addition to submitting your application via the Stanford web portal, please email your CV and cover letter directly to Profs.

    Make fundamental discoveries about gene regulation and the genetics of cardiovascular disease.
    Together with PI and other lab members, design and execute scientific projects.
    Train and collaborate with other lab members in experimental techniques, scientific design, and other skills.
    Design and lead independent projects.
    D. in Biology, Biochemistry, Biophysics, Genetics, Bioengineering, Developmental Biology, or related life science field is preferred. Expert in mouse genetics, with experience studying embryoic or heart development a plus.
    Experience in technology development, molecular biology, genomics, and cellular assay development.
    Experience with quantitative data analysis.
    Curiosity in research and creativity in problem-solving.
    A passion for science and sense of urgency to find new medicines to benefit patients.

    Bachelor's degree in related scientific field and four years of relevant work experience; or Master's degree in a related scientific field and two years relevant experience; or PhD in related science field.

    Comprehensive understanding of scientific principles.
    Expert level knowledge and skills in field of science related to research project.
    General computer skills and experience with databases and scientific applications
    Developing project management skills.

    Frequently stand, walk, twist, bend, stoop, squat, grasp lightly, use fine manipulation, grasp forcefully, perform desk-based computer tasks, use telephone, write by hand, lift, carry, push and pull objects weighing over 40 pounds.

    Occasionally sit, kneel, crawl, reach and work above shoulders, sort and file paperwork or parts.

    Consistent with its obligations under the law, the University will provide reasonable accommodation to any employee with a disability who requires accommodation to perform the essential functions of his or her job.

    May require work in an environment where animals are used for teaching and research.

    Position may at times require the employee to work with or be in areas where hazardous materials and/or infectious diseases are present.

    Employee must perform tasks that require the use of personal protective equipment, such as safety glasses and shoes, protective clothing and gloves, and possibly a respirator.

    May require extended or unusual work hours based on research requirements and business needs.
    uses and promotes safe behaviors based on training and lessons learned.

    Subject to and expected to comply with all applicable University policies and procedures, including but not limited to the personnel policies and other policies found in the University's Administrative Guide, .

    The Cardinal at Work website () provides detailed information on Stanford's extensive range of benefits and rewards offered to employees.

    The job duties listed are typical examples of work performed by positions in this job classification and are not designed to contain or be interpreted as a comprehensive inventory of all duties, tasks, and responsibilities.

    Consistent with its obligations under the law, the University will provide reasonable accommodations to applicants and employees with disabilities.

    Applicants requiring a reasonable accommodation for any part of the application or hiring process should contact Stanford University Human Resources at .All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, protected veteran status, or any other characteristic protected by law.



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