sr research investigator, myeloid diseases - Wilmington, DE, United States - InCyte

Description

Overview

Incyte is a biopharmaceutical company focused on the discovery, development, and commercialization of novel medicines to meet serious unmet medical needs in oncology and inflammation and autoimmunity.

Incyte is committed to the rigorous pursuit of research and development excellence to improve the lives of patients, make a difference in health care, and build sustainable value.

The Company strives to discover and develop first-in-class and best-in-class medicines-advancing a diverse portfolio of large and small molecules.

Job Summary (Primary function)

This position will be responsible for designing, performing, and interpreting in vitro and in vivo studies for drug discovery programs.

This includes the development of relevant model systems for the identification, validation, and screening of small and large molecules against novel therapeutic targets.

The successful candidate is extremely organized, able to work independently, and demonstrates a broad understanding of immunology, hematology, and/or cancer biology, being able to use this knowledge to design and execute a research plan that answers critical questions about compounds and targets under evaluation.

Essential Functions of the Job (Key responsibilities)

• Design, execute, and interpret cell-based in vitro experiments to explore the therapeutic potential of small and large molecules
• Identify and develop assays to screen functional activity of drug candidates
• Culture of cell lines and primary cells
• Isolation and culture of human hematopoietic cells
• Flow cytometry of mouse and human hematopoietic progenitor cells
• Design appropriate in vivo models to answer key biological and pharmacological questions
• Evaluate data, prepare reports and presentations for internal and external meetings
• Excellent record keeping
• Work collaboratively across multiple functional groups within drug discovery and clinical development to achieve key corporate goals
• Coordinate CRO work

Qualifications (Minimal acceptable level of education, work experience, and competency)

• Ph.

D. in Immunology, Hematology, Cancer Biology, Pharmacology, or related field

• Post-doctoral experience in a relevant field
• Preferred previous experience in the pharmaceutical or biotech industry
• Strong background in hematology, immunology, oncogenic signaling pathways, and/or fibrosis
• Able to design and interpret oncology in vivo studies
• Expertise in the following techniques is mandatory: magnetic cell isolation, cell culture, phenotyping of bone marrow progenitors using multicolor flow cytometry, CFU assays using CD34+ cells, ELISA, MSD, Western blot for signaling pathway proteins, basic molecular biology including isolation of nucleic acid and real-time PCR
• Excellent communication skills

Disclaimer:

The above statements are intended to describe the general nature and level of work performed by employees assigned to this job.

They are not intended to be an exhaustive list of all duties, responsibilities, and qualifications. Management reserves the right to change or modify such duties as required.

Incyte Corporation is committed to creating a diverse environment and is proud to be an equal opportunity employer.

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