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Eden Prairie

    Scientist - Eden Prairie, United States - Actalent

    Actalent
    Actalent Eden Prairie, United States

    2 weeks ago

    Actalent background
    Description
    URGENT HIRING FOR SCIENTIST ROLES( LAST CHANCE TO APPLY)


    Description:


    The Senior Scientist/Scientist Cell Sourcing will lead the development ( Senior Scientist), implementation, and refinement of robust protocols for the isolation and expansion of primary liver and kidney cells.

    This role, and team, will be tasked with developing large scale, GMP level protocols to supply cells for R&D cellularization efforts in decellularized liver and kidney scaffolds, and with providing necessary data and documentation support for the preparation of regulatory filings.


    • Coordinate with R&D and manufacturing teams to generate technical plans to develop and optimize targeted primary cell isolation protocols from human liver and kidney tissue
    • Draft protocols, experimental documentation strategies, summaries, and reports
    • Participate in drafting of documentation for regulatory submissions
    • Work with a team on a flexible schedule, according to organ availability, to conduct primary cell isolation protocols
    • Design and execute experiments to develop methods for downstream purification and expansion of primary liver and kidney cells
    • Work with manufacturing and engineering teams to design methods of control for the generation of reliable primary cell manufacturing processes that will adhere to GMP standards
    • Perform characterization of cells obtained from isolation and expansion protocols using standard techniques such as flow cytometry and IHC
    • Assist in coordination and training activities for tech transfer of fully developed protocols to manufacturing teams
    • Communicate using both oral presentations and written documents to broad level of audiences including R&D teams, quality, manufacturing, and upper management
    • Contribute to efforts to understand, explore, and incorporate new technologies to advance programs
    • Author and submit manuscripts, grants, and abstracts with approval of senior management
    Normal week - 50% lab work / 50% desk based work. Needs to be able to adjust and be flexible with this.


    Skills:
    cell culture, adherent celll, gmp, r&d


    Top Skills Details:
    cell culture, adherent celll, gmp, r&d


    Additional Skills & Qualifications:
    Doctor of Philosophy (PhD) in Tissue Engineering, Biomedical Engineering, Biological Sciences, or related field

    2+ (associate) 5+ ( senior ) years of relevant experience working with primary mammalian cell isolation and culture

    1+ years of relevant industry experience working in a quality-controlled research environment

    Experience with primary cell isolations (required Sr )

    knowledge of liver and/or kidney function and experience working with cells from these organs (required Sr

    Experience working with human tissue

    knowledge of perfusion control and fluid flow dynamics

    Experience with cell purification techniques such as MACS sorting or size exclusion

    Experience with flow cytometry

    Experience with immunohistochemistry or immunofluorescence staining


    Experience Level:
    Expert Level

    About Actalent

    Actalent is a global leader in engineering and sciences services and talent solutions.

    We help visionary companies advance their engineering and science initiatives through access to specialized experts who drive scale, innovation and speed to market.

    With a network of almost 30,000 consultants and more than 4,500 clients across the U.S., Canada, Asia and Europe, Actalent serves many of the Fortune 500.

    Diversity, Equity & Inclusion

    At Actalent, diversity and inclusion are a bridge towards the equity and success of our people.

    DE&I are embedded into our culture through:

    • Hiring diverse talent
    • Maintaining an inclusive environment through persistent self-reflection
    • Building a culture of care, engagement, and recognition with clear outcomes
    • Ensuring growth opportunities for our people


    The company is an equal opportunity employer and will consider all applications without regard to race, sex, age, color, religion, national origin, veteran status, disability, sexual orientation, gender identity, genetic information or any characteristic protected by law.

    If you would like to request a reasonable accommodation, such as the modification or adjustment of the job application process or interviewing process due to a disability, please email ) for other accommodation options.
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