Associate Scientist, Translational Biomarkers - Madison, United States - Arrowhead Pharmaceuticals

Description

Job Description

Arrowhead Pharmaceuticals, Inc. (Nasdaq: ARWR) is a clinical stage biopharmaceutical company that develops medicines that treat intractable diseases by silencing the genes that cause them. Using a broad portfolio of RNA chemistries and efficient modes of delivery, Arrowhead therapies trigger the RNA interference mechanism to induce rapid, deep, and durable knockdown of target genes. RNA interference, or RNAi, is a mechanism present in living cells that inhibits the expression of a specific gene, thereby affecting the production of a specific protein. Arrowhead's RNAi-based therapeutics leverage this natural pathway of gene silencing.

Arrowhead is focused on developing innovative drugs for diseases with a genetic basis, typically characterized by the overproduction of one or more proteins that are involved with disease. The depth and versatility of our RNAi technologies enables us to potentially address conditions in virtually any therapeutic area and pursue disease targets that are not otherwise addressable by small molecules and biologics. Arrowhead is leading the field in bringing the promise of RNAi to address diseases outside of the liver, and our clinical pipeline includes disease targets in the liver and lung with a promising pipeline of preclinical candidates.

Arrowhead's corporate headquarters is in Pasadena, CA with research and development teams in Madison, WI and San Diego, CA. Our employees are nimble, science-driven innovators who are collaborating to bring new therapies to patients in need.

The Position

The Associate Scientist will be part of a team responsible for performing various analytical assays to support translational biomarker strategies for drug development candidates. The ideal candidate should have excellent hands-on laboratory experience and possess a strong understanding of the scientific principles of common laboratory techniques. He/she will also have strong communication skills, ability to work in a matrixed-based, fast-paced environment, solid problem-solving abilities, and a commitment to excellence.

Responsibilities

• Conduct/execute in vitro, ex vivo and/or in vivo studies to facilitate drug discovery and development with some independence
• Perform gene or protein biomarker expression analysis using various methods
• Propose and carry out ways to optimize test methods
• Occasionally present research findings to project teams and governance bodies and prepare study reports
• Occasionally read relevant scientific literature and propose applicable suggestions for problem-solving
• Perform critical experiments with adherence to prescribed specifications
• Support team lab management activities
• Maintain a high level of productivity and quality in the lab

Requirements:

• Bachelor of Science in Biology or related field
• 3+ years of experience in cell biology, molecular biology, immunology, pharmacology or a related field of biology
• Experience in standard cellular and molecular biology techniques (Cell culture, ELISA, Cell-based assays, Immunofluorescence, Western blotting, Microscopy, RNA/DNA isolation, qPCR)
• Excellent problem-solving skills in assay design, data analysis and interpretation
• Excellent oral and written communication skills
• Self-motivated team player with the ability to thrive in a fast-paced, multi-disciplinary, matrixed environment

Preferred:

• Industrial experience in a regulated lab environment a plus

Arrowhead provides competitive salaries and an excellent benefit package.

All applicants must have authorization to work in the US for a company.

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