Chief of and medical - San Francisco, CA, United States - Eli Lilly and Company

Description

We are a global healthcare leader headquartered in Indianapolis, Indiana.

Our employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism.

At DICE Therapeutics, a wholly owned subsidiary of Eli Lilly, we design and develop innovative therapies in immunology for patients with debilitating disease.

Seeking to create a future where convenient oral medicines with biologic-like efficacy are available to patients with serious medical conditions, we are developing oral alternatives to medicines currently limited to injectable forms.

We have an open position to head a growing Immunology department. This group is responsible for target identification and biology leadership for all DICE programs.

Our Immunology scientists are experts in target biology and solve basic biology questions that relate to the inhibition of our targets with small molecule compounds.

They conceptualize novel assay systems for in vitro and in vivo testing of drug candidates and work in close collaboration with our in vitro pharmacology team to design assay cascades in support of drug development.

This individual will be responsible for all immunology aspects of our drug development programs. Identification of targets with a medium to high degree of validation, a clinical need for orally bioavailable medication, and a structural opportunity to develop small molecule inhibitors that will disrupt target function through allosteric or isosteric mechanisms
Oversight of design and implementation of research plans to prosecute those targets with biochemical, biophysical, cell based, and primary cell-based assays, as well as in vivo PD and efficacy modeling
Building of expertise around target biology, with particular focus on aspects that relate specifically to small molecule inhibition and how it might mimic or differ from antibody mediated inhibition
Mentoring and leading a team of currently 4 PhD level FTE dedicated to the aforementioned tasks
When appropriate, accomplish results through outsourcing efforts
PhD degree in immunology or a related field
~10-15 years of proven experience in immunology and inflammation, with 5-10 years of that experience attained in an industrial setting
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