Molecular Biologist III - Austin, United States - Texas Department of Aging & Disability Services

Description

Job Description:

Under limited supervision of the Genetic Sequencing Branch Manager and Team Lead, following standard or developmental protocols, performs highly complex and advanced molecular testing and typing using Next Generation Sequencing (NGS).

Performs Bioinformatics analysis on NGS data. Assists with the development and implementation of additional molecular and epidemiological techniques. Ensures standard protocols and proper quality controls are followed for all the tests performed in the lab. Assists in evaluating the quality of reagents and in managing material resources. Consults with epidemiologists regarding test application and interpretation. Trains individuals on molecular techniques. Serves as Senior Molecular biologist within the laboratory; assumes additional duties as assigned. Duties are performed with significant latitude to interpret standard protocol, with significant use of scientific knowledge and judgment.

Safe operation of either a state owned vehicle or personal vehicle is required to conduct state business and an acceptable driving record must be maintained in accordance with DSHS Policy OS-, Fleet Operations and Management & Procedures and standards developed by the Texas Department of Public Safety.

Essential Job Functions:

Attends work on a regular and predictable schedule in accordance with agency leave policy and performs other duties as assigned.

EJF 1. Under the technical guidance of the Branch Manager/Team Lead, performs highly complex (senior-level) molecular biology work. Plans and conducts analysis of specimens using NGS by processing specimens in accordance with current protocols and regulations. (45%)
EJF 2. Performs bioinformatics analysis on NGS data using various bioinformatics software or pipelines. Communicates with epidemiologists regarding findings to help investigate outbreaks. (25%)
EJF 3. Investigates quality assurance problems, recommends and implements approved corrective actions. Initiates troubleshooting of tests and instruments and completes routine adjustments as indicated by Team Lead/Manager. Proposes solutions to problems, implements approved changes according to direction from Team Lead/Group Manager. Evaluates daily quality control records, performs preventive maintenance on laboratory equipment, and ensures all records are updated daily. Prepares solutions, reagents and other components as needed/assigned. Ensures an accurate and updated inventory of team's unique supplies and reagents is available. (15%)
EJF 4. Analyzes specimen and test data to identify unusual patterns of either specimen submission or test results. Evaluates test results, reviews and releases outgoing reports. Assesses atypical test results, consults with Team Lead/Group Manager and orders retesting as directed.

Assists Team Lead/Manager with determination of circumstances surrounding an incorrect report and with the initiation of corrective action to ensure accurate and consistent results are reported to customers.

(5%)
EJF 5. Researches current scientific literature, selects, interprets, and shares information for adaptation in the lab. Performs evaluation/validation studies and presents data to Team Lead/Manager. Assists in providing consultation and services to internal and external customers regarding specimen requirements, test results, and interpretation. Answers questions regarding laboratory testing methods. Assists Team Lead/Manager in drafting and reviewing standard operating procedures (SOPs). Updates computer data files, software programs, and SOPs as directed by Team Lead/Manager.

Participates in a cross-training program as both a student and instructor by teaching and/or demonstrating molecular techniques to other laboratory personnel, volunteers or students and documenting training for staff.

(5%)
EJF 6. Performs other duties as assigned by the Team Leader/Manager.

Other duties as assigned include but are not limited to actively participating and/or serving in a supporting role to meet the agency's obligations for disaster response and/or recovery or continuity of operations (COOP) activation.

Such participation may require an alternate shift pattern assignment and/or location.

Based on your work area, consistently comply with DSHS Laboratory, local, state and federal guidelines to ensure a safe functioning laboratory.

(5%)
Knowledge Skills Abilities:
Have an earned bachelor's, master's, or doctoral degree in a chemical, physical, biological or clinical laboratory science or medical technology from an accredited institution; or

Experience and education may be substituted as defined by the Clinical Laboratory Improvement Amendments of (CLIA '88) Standards.
Strong background and working knowledge of molecular biology principles and techniques such as NGS and PCR.

Skill in the operation of molecular as well as general laboratory equipment and in the use of a computer and applicable software for bioinformatics analysis.

Ability to interpret written protocols and to follow procedures
Ability to conduct advanced molecular analyses and tests, to interpret molecular biology test results, and to prepare reports.
Ability to plan and prioritize assignments
Ability to detect malfunctions in test protocols and errors in transcribed results; make recommendations /implementations for corrective action
Knowledge of quality assessment and quality control functions and CLIA/CAP regulations. Knowledge of validation process as required by CLIA/CAP.
Knowledge of unidirectional workflow and aseptic techniques to reduce the potential for contamination
Ability to teach molecular biology concepts and procedures.
Ability to communicate technical instructions and interact effectively with staff.
Ability to maintain positive customer relations.
Ability to work independently and make technical decisions based on professional knowledge and experience.