Research & Development Scientist III - Houston - Baylor Genetics

    Baylor Genetics
    Baylor Genetics Houston

    5 days ago

    Description
    SUMMARY:

    We are seeking a highly motivated and experienced R&D Scientist to join our dynamic, fast-paced team focused on driving innovation in the genomic diagnostics field. The R&D Scientist will play a critical role in developing new sequencing based diagnostic assays.

    This role is ideal for a scientist with a Ph.D. in molecular biology, biochemistry, genetics, or a related field, and a strong background in assay development and validation. The successful candidate will play a key role in developing and optimizing tissue biopsy and liquid biopsy workflows, contributing to the advancement of cutting-edge molecular diagnostic assays.

    The candidate will independently lead assay development projects while collaborating with cross-functional teams, both within and outside the department, under general supervision.

    REQUIRED QUALIFICATIONS:
    • Ph.D. in molecular biology, biochemistry, genetics, or related discipline.
    • Minimum of 3 years of hands-on experience in sequencing workflow and assay development, preferably in an industrial or clinical diagnostic setting.
    • Proven expertise in tissue FFPE, fine needle biopsy, and/or cfDNA sequencing workflows.
    • Strong understanding of molecular assay development and validation principles.
    • Proficiency in molecular biology techniques such as PCR, qPCR, NGS, and nucleic acid extraction.
    • Experience with data analysis tools and software relevant to NGS.
    • Excellent problem-solving skills and attention to detail.
    • Strong communication and collaboration skills.
    PREFERRED QUALIFICATIONS:
    • Agility in learning new concepts and skills and applying them to R&D work.
    • Experience in R&D assay transfer to operation.
    • Experience working in a regulated environment (e.g., CLIA, CAP).
    • Familiarity with automation platforms and liquid handling systems.
    DUTIES AND RESPONSIBILITIES:
    • Lead and contribute to the design, development, and optimization of molecular assays, with a focus on tissue and cfDNA workflows.
    • Develop DNA library preparation chemistry and workflow for FFPE tissue samples.
    • Refine chemistry and workflows for cell-free DNA library preparation.
    • Design and execute experiments, analyze data, and interpret results to support assay performance and troubleshooting.
    • Define assay performance metrics and collaborate with the validation team on designing verification & validation study.
    • Collaborate cross-functionally with bioinformatics, validation, automation, and clinical teams to ensure robust assay development, validation and transfer.
    • Maintain detailed records of experimental procedures, results, and protocols in accordance with regulatory and quality standards.
    • Present findings and updates to internal stakeholders and contribute to technical reports and publications.
    • Keep up to date with emerging technology and scientific trends, and contribute to new assay improvement or development ideas.
    • Evaluate assay improvement and novel ideas through experimental approach.
    • Adhere to the Code of Conduct as outlined in the Baylor Genetics Compliance Program.
    • Perform other job-related duties as assigned
    PHYSICAL DEMANDS AND WORK ENVIRONMENT:
    • Frequently required to sit
    • Frequently required to stand
    • Frequently required to utilize hand and finger dexterity
    • Frequently required to talk or hear
    • Frequently required to utilize visual acuity to operate equipment, read technical information, and/or use a keyboard.
    • Occasionally exposed to bloodborne and airborne pathogens or infectious materials
    EEO Statement:

    Baylor Genetics is proud to be an equal opportunity employer dedicated to building an inclusive and diverse workforce. We do not discriminate based on race, religion, color, national origin, sex, sexual orientation, age, gender identity, veteran status, disability, genetic information, pregnancy, childbirth, or related medical conditions, or any other status protected under applicable federal, state, or local law.

    Note to Recruiters:

    We value building direct relationships with our candidates and prefer to manage our hiring process internally. While we occasionally partner with select recruitment agencies for specialized roles, we do not accept unsolicited resumes from recruiters or agencies without a written agreement executed by the authorized signatory for Baylor Genetics ("Agreement"). Any resumes submitted to Baylor Genetics in the absence of an Agreement executed by Baylor Genetics' authorized signatory, will be considered the property of Baylor Genetics, and Baylor Genetics will not be obligated to pay any associated recruitment fees.

    Equal Opportunity Employer
    This employer is required to notify all applicants of their rights pursuant to federal employment laws. For further information, please review the Know Your Rights notice from the Department of Labor.

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