Description
Job Description
Job DescriptionReporting to the Associate Director, Product Sciences, CARGO is seeking a self-motivated and versatile individual to join us as a
Scientist within the Analytical Development organization. In this position, you will work closely with the Process Development, Quality Control, Analytical Operations, Quality Assurance, Translational Medicine, Biometrics, and Regulatory team members and will contribute to flow cytometry-based assay development for product understanding of CARGO Therapeutics' pipeline candidates, method transfer and/or qualification, SOP/technical report authoring and review, method life cycle management, data analysis, and execution of routine analytical testing. This individual must be highly organized, a quick learner, and largely independent. This an onsite, lab-based role located in San Carlos, CA.
WHAT YOU'LL DO AT CARGO THERAPEUTICS- Method development and qualification of extended characterization (EC) and/or lot release flow cytometry-based assays to interrogate immune cell biology and function, including compilation of associated SOPs (Standard Operating Procedures) and technical reports
- Collaborate closely with QC groups to support starting material, in process, and drug product method optimizations, troubleshooting, root cause investigations, and other activities related to method validation and lifecycle management
- Support the PD group in execution of methods and fit for purpose development of assays to assess characterization of process and product attributes
- Work with the AO team to support EC testing of clinical manufacturing material, method training/transfer, data analysis, troubleshooting, and review, as needed
- Participate in technology-transfer activities with internal and external partners to support early‐stage clinical programs
- Successfully execute and document laboratory procedures and experiments with great attention to detail, including Electronic Lab Notebook (ELN) record keeping
- Analyze data, prepare reports, presentations, and data packages for review
- Perform additional duties as assigned
THE RIGHT STUFF: Required Experience & Qualifications- Demonstrated experience in cell therapy, immunology, or a closely related field; PhD with 0‐2+ years of experience (MS with 4+ years or BS with 6+ years will also be considered); prior industry experience is preferred
- Industry experience in cell and gene therapy within an Analytical Development role is preferred
- Technical expertise in relevant technologies used in cell therapies, with an emphasis on multiparameter flow or spectral cytometry and cell sorting; experience with quantitation of antigen density, phospho‐flow, or co-culture assays is preferred
- Experience with release or extended characterization flow-based method development assessing T-cell phenotypes, as well as in method transfer and qualification, to support routine testing in a GLP and/or GMP environment
- Technical writing experience in a regulatory environment such as protocols, reports, and SOPs
- Proficient in MS Word, Excel, and PowerPoint, with knowledge related to scientific data analysis software for applications such as GraphPad Prism, JMP, and NovoExpress/FCS Express (flow/spectral cytometry)
- Comfortable in a fast-paced environment with minimal direction and able to adjust workload based upon changing priorities
- Self-motivated, detail-oriented, and willing to accept temporary responsibilities outside of initial job description
- Highly effective written and oral communication skills to address a wide variety of audiences and governing bodies
- Demonstrated resilience, diplomacy, influence, relationship-building, and problem-solving skills in various situations
- Willingness to travel to external partner locations for method‐related support, when necessary
PAY RANGEThe combined pay range for this role is $100,000 - $138,000. Title and salary will be based on our assessment of skills and experience relevant to our needs for the role.
ABOUT CARGO THERAPEUTICS CARGO Therapeutics, Inc. is a clinical-stage biotechnology company positioned to advance next generation, potentially curative cell therapies for cancer patients. CARGO's programs, platform technologies, and manufacturing strategy are designed to directly address the limitations of approved cell therapies, including limited durability of effect, safety concerns and unreliable supply. CARGO is currently evaluating its lead program, CRG-022, an autologous CD22 chimeric antigen receptor (CAR) T-cell therapy candidate, in a potentially pivotal Phase 2 clinical trial in patients with large B-cell lymphoma (LBCL) whose disease relapsed or was refractory (R/R) to CD19 CAR T-cell therapy. CARGO also plans to evaluate CRG-022 in patients at earlier stages of disease, including LBCL and other hematologic malignancies. Beyond its lead program, CARGO is leveraging its proprietary cell engineering platform technologies to develop a pipeline of programs that incorporate multiple transgene therapeutic "cargo" designed to enhance CAR T-cell persistence and trafficking to tumor lesions, as well as to help safeguard against tumor resistance and T-cell exhaustion. CARGO's founders are pioneers and world-class experts in CAR T-cell therapy, and its team has significant experience and success developing, manufacturing, launching and commercializing oncology and cell therapy products. For more information, please visit the CARGO Therapeutics website at https://cargo- us to help make a difference
EEO & EMPLOYMENT ELIGIBILITY CARGO Therapeutics, Inc. is committed to building a diverse, equitable, and inclusive company. We provide equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability, or veteran status. CARGO Therapeutics, Inc. also complies with all applicable national, state, and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification required of applicable law. CARGO Therapeutics requires all new hires to be fully vaccinated against COVID-19 as of their start date. This requirement is a condition of employment at CARGO Therapeutics, and it applies regardless of whether the position is located at a CARGO Therapeutics site or is fully remote. If you are unable to receive the vaccine due to a disability or serious medical condition, or because it is prohibited because of your sincerely held religious beliefs, you will have an opportunity to request a reasonable accommodation.
