Senior Scientist I, Analytical R&D - North Chicago - AbbVie

    AbbVie
    AbbVie North Chicago

    4 days ago

    Default job background
    Full time
    Description

    Job Description

    AbbVie is a global biopharmaceutical company dedicated to discovering and delivering innovative medicines that solve serious health issues today and address the medical challenges of tomorrow. Our mission is to have a remarkable impact on people's lives across several key therapeutic areas – immunology, oncology, neuroscience, and eye care – and products and services in our Allergan Aesthetics portfolio.

    We are seeking a highly motivated Senior Scientist I who can conceive, implement and execute novel scientific research and development. This individual will independently develop and optimize new methods and techniques to generate reliable and reproducible data in a timely manner, demonstrate broad versatile technical expertise, and support early phase development of New Chemical Entities (NCEs) drug substance in both preclinical and clinical phases.

    This position will focus primarily on transitioning NCEs from Discovery into Development Sciences and the individual will independently serve as an Analytical Research and Development representative in a highly cross-functional team, which includes Discovery, Process Chemistry, Quantitative and Translational ADME Sciences (QTAS), Safety Pharmacology, Pre-Clinical Safety (PCS), and Molecular Profiling and Drug Delivery (MPDD).

    Responsibilities:

    • Apply analytical separation and detection modes for complex impurity profiling of pharmaceutical drug substances to further the understanding of emerging non-GMP and cGMP manufacturing processes.
    • Responsible for leading the analytical aspects of a project while working with other functional areas to advance projects through the development pipeline.
    • Utilize understanding of a range of analytical techniques to conduct research and development studies related to small-molecule drug substances, intermediates, starting materials, impurities, and impurity profiling.
    • Support new product development with advanced method development and validation, technical transfer packages, and generation of technical data in support regulatory requirements.
    • Highly autonomous and productive in performing laboratory research or method development, requiring only minimal direction from or interaction with supervisor.
    • Formulate conclusions and design follow-on experiments based on multidisciplinary data.
    • May initiate new areas of investigation that are scientifically meaningful, reliable, and can be incorporated directly into a research or development program.
    • Process, interpret, and visualize data to facilitate project team decisions.
    • Communicate and collaborate with cross-functional groups and departments, especially process chemistry, process engineering, and technical operations.
    • Routinely demonstrate scientific initiative and creativity in research or development activities and maintain a high level of productivity in the lab.
    • Responsible for method development, testing procedures, and implementation of analytical control strategies to help the advancement of drug discovery candidates.
    • Raise the bar and never be satisfied with the status quo.
    • Understand and adhere to corporate standards regarding code of conduct, safety, appropriate handling of materials, controlled drug and radioactive compounds, and GxP compliance, where applicable.

    Qualifications:

    • Bachelor's, Master's, or Ph.D. in Chemistry (Analytical/Organic/Medicinal) or Pharmaceutical Sciences typically with minimum 10 (BS), 8 (MS), or 0 - 2 (Ph.D.) years related industry experience.
    • Strong technical background in chemistry, excellent analytical problem-solving skills. Capable of independently developing and troubleshooting analytical methods.
    • Demonstrated experience with HPLC analysis and method development preferred along with expertise and fundamental understanding of spectroscopic techniques.
    • Comfortable discussing organic chemistry topics within analytical R&D and with partner functions. Hands-on experience with synthetic organic chemistry preferred.
    • Self-motivated, hard-working, detail-oriented individual able to work in a fast-paced team environment.
    • Experience in the use of computerized data handling systems.
    • High-quality written and oral communication skills and ability to interact effectively with interdisciplinary scientists and engineers.
    • Practical knowledge of organic structure, functional groups, chemistry, and modern spectroscopic techniques as applied to small-molecule analytical analysis.
    • Builds strong relationships with peers and cross-functionally with partners outside of the team to enable higher performance.
    • Learns fast, grasps the
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