- Develop new bioanalytical methods for quantification of small molecule compounds and oligonucleotides (ASO, siRNA etc.) in biological matrices.
- Analyze biological samples (plasma, CSF, tissue etc.) and timely deliver high quality bioanalytical data to support non-clinical and possible clinical studies.
- Oversee non-GLP and GLP bioanalytical activities at CROs. Provide scientific guidance on method transfer/development, qualification/validation, and sample analysis at CROs.
- Write and review study protocols and bioanalytical reports that are suitable for inclusion in registration dossiers.
- Manage multiple projects within timelines according to high scientific and ethical standards.
- Evaluate and implement new bioanalytical technologies for solving DMPK challenges or project needs.
- Publish scientific papers and present at external scientific meetings.
- Ph.D. in analytical chemistry, biochemistry, or related discipline with 0-3 years relevant industry experience.
- In-depth knowledge and extensive experience with LC-MS/MS bioanalysis of small molecule compounds are required. Experience with other modalities such as oligonucleotides and proteins is desired.
- Capable of performing bioanalysis and solving bioanalytical technical problems.
- Familiar with bioanalytical method validation regulatory guidance and GLP regulations.
- Understanding of pharmacokinetics and drug metabolism principles.
- Excellent communication skills
- Strong records of scientific publications
- Ability to work independently in a fast-paced environment, as well as in a team setting.
- Experience in ligand binding assays such as ELISA and MSD assays is a plus.
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Scientist, DMPK - Cambridge, MA, United States - Biogen
Description
Job Description
About This Role
Biogen is seeking a highly motivated scientist with excellent knowledge and experience in LC-MS/MS bioanalysis to join the Drug Metabolism and Pharmacokinetics (DMPK) department. The candidate will be responsible for bioanalytical support of discovery and development programs, including small molecule compounds and oligonucleotides. Experience in regulated bioanalysis and GLP studies is preferred. The candidate should be able to effectively manage and prioritize multiple projects to ensure timely support of the projects. Excellent communication and interpersonal skills are required, along with scientific thinking and problem-solving skills.
What You'll Do
Who You Are
You love bioanalysis and are passionate about applying bioanalysis to impact drug discovery and development. You love learning new technological skills and working through collaboration.
Qualifications
Required Skills
Additional Information
Why Biogen?
We are a global team with a commitment to excellence, and a pioneering spirit. As a mid-sized biotechnology company, we provide the stability and resources of a well-established business while fostering an environment where individual contributions make a significant impact. Our team encompasses some of the most talented and passionate achievers who have unparalleled opportunities for learning, growth, and expanding their skills. Above all, we work together to deliver life-changing medicines, with every role playing a vital part in our mission. Caring Deeply. Achieving Excellence. Changing Lives.
At Biogen, we are committed to building on our culture of inclusion and belonging that reflects the communities where we operate and the patients we serve. We know that diverse backgrounds, cultures, and perspectives make us a stronger and more innovative company, and we are focused on building teams where every employee feels empowered and inspired. Read on to learn more about our DE&I efforts.
All qualified applicants will receive consideration for employment without regard to sex, gender identity or expression, sexual orientation, marital status, race, color, national origin, ancestry, ethnicity, religion, age, veteran status, disability, genetic information or any other basis protected by federal, state or local law. Biogen is an E-Verify Employer in the United States.
PDN-9c0bc2d8-69ce-422e-825e-7e0c4c135e5d
