Senior Scientist, Product - Seattle, Washington, United States

Job Description · ATTENTION MILITARY AFFILIATED JOB SEEKERS - Our organization works with partner companies to source qualified talent for their open roles. The following position is available to Veterans, Transitioning Military, National Guard and Reserve Members, Military Spous ...

Job description

Job Description

ATTENTION MILITARY AFFILIATED JOB SEEKERS - Our organization works with partner companies to source qualified talent for their open roles. The following position is available to Veterans, Transitioning Military, National Guard and Reserve Members, Military Spouses, Wounded Warriors, and their Caregivers. If you have the required skill set, education requirements, and experience, please click the submit button and follow the next steps. Unless specifically stated otherwise, this role is "On-Site" at the location detailed in the job post.

Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment.

We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives.

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Job Description:

The Cell Therapy Product and Analytical Sciences (PAS) team is seeking a Senior Scientist to support the development of the Allogeneic Cell Therapy pipeline programs.

The goal of BMS Cell Therapy is to revolutionize medicine by re-directing the body's immune cells to specifically target cancer cells.

Allogeneic or "off-the-shelf" CAR T cells are generated from healthy donor-derived T cells rather than the patient's T cells and can be delivered to patients without manufacturing wait time.

The Product and Analytical Sciences Team is responsible for developing and executing in depth donor starting materials and drug product characterization strategies, as well as mechanism of action studies to support the development of allogeneic and autologous CAR T cell therapies.

The primary focus of the Product and Analytical Senior Scientist role will be to collaborate with PAS team members to build in depth allogeneic CAR T cell donor, product and manufacturing process knowledge, with particular focus on exploratory/investigational studies to drive:

In depth Healthy Donor cellular starting materials characterization to support donor pre-screening, selection, cell sourcing workflows across allogeneic cell therapy program Developing and executing complex cellular immunoassays and generating comprehensive datasets for correlative analysis execution and the building of in-depth donor > manufacturing process > drug product understanding across pipeline Allogeneic Cell Therapy Programs Support process development studies and investigations by building and mining in depth data packages and generating hypothesis-driven conclusions and proposed risk mitigation strategies Support the identification of drug product critical quality attributes (CQA) to inform the overall drug product control strategy and the generation of drug product quality target product profiles taking into account safety and efficacy of drug products Generate in-depth product characterization data packages for inclusion in regulatory submissions (with specific attention to Module 3 S.3.1.

Elucidation of Structure and S.3.2. Product Impurities) and to answer agencies' information requests

Successful candidates will have a strong foundation in Immunology and human T cell biology and experience with the design, optimization, and implementation of a broad range of in vitro cell-based and/or molecular T cell characterization assays (i.e. cytotoxicity assays, proliferation, cytokine production assays, multi-color conventional and spectral flow cytometry, gene editing, transcriptome and proteome profiling, etc.).

Prior research experience with T cells / CAR T cells (including cell therapy research, allogeneic hematopoietic stem cell transplantation, etc) will be prioritized.

This role is highly collaborative and requires strong ability to prioritize deliverables, independence, a demonstrated ability to support cross-functional teams, attention to detail, a healthy sense of urgency, and a passion for exploratory and investigational science.

Candidates with prior people management experience will be prioritized.


Responsibilities:
Work collaboratively with the Product and Analytical Sciences Team members to identify, prioritize and support immediate PAS team goals
Design, optimize, and execute in-depth characterization experiments and generate comprehensive characterization data packages focused on allogeneic cell therapy starting materials and pipeline CAR T cell products to enable immediate PAS team deliverables, leveraging cutting edge phenotypic, functional, metabolic, gene expression profiling tools and platforms
Answer high priority PAS Team targeted questions, such as identification of donor starting material attributes that best correlate with high quality drug product manufacturing, investigation of product mechanisms of action (MoA), manufacturing investigations, responses agency's information requests (IRs), data package generation in support of regulatory document submissions
Present experimental findings and project updates at cross-functional team meetings and to BMS leadership
Serve as allogeneic starting materials and product biology subject matter expert in multidisciplinary team settings that includes CMC functions, regulatory, non-clinical, clinical, translational teams
Collaborate with members of the Product and Analytical Sciences Team to identify, prioritize, and develop novel/next generation Analytical Platforms and Technologies to interrogate cell therapy starting materials and drug product function
Author, review, and approve electronic notebook entries (ELN), technical documents, including methods, protocols, reports, and SOPs
Execute method and instrument troubleshooting

Additional Qualifications/Responsibilities
Qualifications

PhD and 3+ years; MS and 10+ years; BS and 12+ years in Immunology, Cell Biology, Bioengineering, or relevant discipline

Expertise in cellular and molecular immunology. Prior research with cell therapy products (i.e. autologous or allogeneic T/CAR T cells, NK cells, HSC and/or iPSC) will be prioritized
Experience with routine and next generation analytical platforms for the characterization of T cell phenotype, differentiation, and function (i.e. cell-based immunoassays, cytokine/proteome analysis platforms, in vitro live imaging systems, conventional and spectral flow cytometry, metabolic profiling, CRISPR and gene editing, transcriptome and proteome profiling, etc)
Experience with data analysis and visualization software (Flowjo, OMIQ, JMP, EXCEL, etc.) and/or coding-based analysis (R, Python, etc.)
Independence in experimental design, data analysis, interpretation, and presentation
Ability to work in a high-paced, cross-functional team environment, meet deadlines, & prioritize work on multiple projects
Attention to detail and excellent interpersonal, written and verbal communication skills
Experience in managing and/or mentoring more junior scientists

Preferred Qualifications:
Experience with big/omic data analysis will be prioritized
Track record of successful internal and/or external scientific collaborations

If you come across a role that intrigues you but doesn't perfectly line up with your resume, we encourage you to apply anyway.

You could be one step away from work that will transform your life and career.


Compensation Overview:
Seattle - WA: $124,190 - $150,483