High-Throughput Screening Research Associate II, III - San Francisco - Amber Bio

    Amber Bio
    Amber Bio San Francisco

    1 day ago

    Pharmaceutical / Bio-tech
    Description

    Amber Bio is a biotechnology company pioneering new gene editing modalities using multi-kilobase edits to reach previously undruggable patient populations. Founded by pioneers in the CRISPR field from leading institutions for gene editing research, the company is developing a first-of-its-kind RNA editing platform that can correct thousands of bases at once, thereby correcting genetic mutations safely and reversibly. If you are interested in building a new frontier in genetic medicine, we welcome you to apply.

    Job Description: High-Throughput Screening Research Associate II, III (Biodesigner II, III)

    Responsibilities:

    • Perform massively parallel reporter assays and high-throughput screens across diverse cellular contexts using cellular and molecular readouts.
    • Develop and execute molecular biology workflows such as vector design and cloning, DNA/RNA extraction, RT-PCR, qPCR, and next-generation sequencing.
    • Support cell culture activities and experiments in multiple cell lines, at small and large scales.
    • Design and execute cell-based assays (AAV/lentiviral transduction, transfection, flow cytometry, immunostaining, and other plate reader assays).
    • Engineer and characterize cell-based systems using synthetic biology tools and techniques.
    • Conduct and troubleshoot experiments, independently and in collaboration with colleagues, to optimize screening throughput, sensitivity, and specificity.
    • Proactively troubleshoot technical issues and recommend potential corrective actions based on personal observations and literature searches.
    • Prepare summaries of data and present internally to colleagues and management.
    • Draft SOPs, follow protocols, diligently document experimental data in lab notebooks, and organize and maintain electronic work records.
    • Author scientific reports and data summaries.
    • Collaborate with cross-functional teams to meet project goals, bridging early discovery with high-throughput screens to nominate and optimize candidates for further characterization.

    Qualifications:

    • Bachelor's or Master's degree in Biology, Biochemistry, Chemical Engineering, Biological Engineering, or a related field.
    • At least 2 years of industry wet lab experience.
    • Mammalian cell culture experience (culturing, transfecting and transducing cells, and DNA/RNA purification from cells).
    • Molecular biology expertise (vector design and cloning, qPCR, primer and probe design, DNA/RNA extraction workflows)
    • Critical thinker with excellent communication skills who thrives in a multidisciplinary, fast-paced team environment.
    • Strong written and verbal communication skills.

    Preference will be given to those who display:

    • High throughput screening assay development in an industry setting.
    • High motivation, with a strong work ethic and dedication to generating impact.
    • Attention to detail, with the ability to extract deep insights from data.
    • First-principles thinking, and an ability to refine one's intuition based on additional data.
    • Ability to go from ideation to data in an independent fashion.
    • Long-term personal vision with defined career goals.
    • High EQ with team-oriented thinking.
    • Experience with pooled, high-throughput screens using next-generation sequencing-based readouts, and/or preparing screening plasmid libraries from synthesized oligo arrays.
    • Experience with CRISPR-Cas systems and/or gene editing and delivery technologies.
    • Experience preparing next-generation sequencing libraries (Illumina, PacBio, and/or Nanopore platforms).

    If you have a passion for advancing gene editing technologies and desire to be part of a pioneering biotech company, we encourage you to apply and join our ambitious team.

    Please apply directly through LinkedIn.

    Amber Bio is an equal-opportunity employer and encourages applications from candidates of diverse backgrounds. We value diversity and are committed to creating an inclusive and supportive work environment for all employees.

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