Post Doc Res Assoc - Campus
1 day ago
Job description
Job SummaryThe Jurynec Lab (Department of Orthopaedics, ) is looking for a highly motivated and independent Post Doctoral Research Fellow to be part of a multidisciplinary team studying the genetics of osteoarthritis.
The lab uses human genetics, bioinformatics, molecular biology, and animal models to understand the factors that contribute to the onset and progression of osteoarthritis.
The Jurynec Lab has identified over 100 candidate gene variants that segregate with osteoarthritis in large pedigrees.We are analyzing candidate gene functions in zebrafish and generating mice carrying human disease alleles to understand the contribution of these genes to the osteoarthritis phenotype.
Analyses include CRISPR /Cas9 genome editing in mice and zebrafish, scRNA-seq, spatial profiling, WES / WGS , and tissue culture.
The candidate should be prepared to analyze gene function in vivo and perform genetic and chemical screens in vitro to identify potential therapeutics.
The lab is funded by the NIH and foundation grants. The applicant will be responsible for leading independent projects under the guidance of the PI. These studies include performing experiments with zebrafish, mice, and tissue culture. The applicant will also be responsible for the maintenance and breeding of zebrafish and mice.Responsibilities
Essential Functions 1. Performs and directs specialized and complex lab tests, experiments and surgical procedures for studies. 2.
Assists the Principal Investigator in the design, implementation and performance of new protocols and procedures as well as the modification of existing techniques.
3. Reviews scientific journals, abstracts and other literature for information concerning experimental procedures. 4. Makes advanced statistical calculations, analyzes data and prepares reports summarizing research results. 5. Operates complex and highly specialized laboratory and surgical instruments and equipment. Instructs others in their use. 6. Maintains a log of supplies used in procedures. 7. May supervise, train and review the work of laboratory personnel. 8. May prepare equipment and rooms for studies. 9. May assist with preparing budgets. Problem-Solving The Post Doc assists in the development of research protocols and designs. Modifies and implements procedures. Records and interprets research results. The incumbent works independently, under the general supervision of most senior laboratory personnel. Work may include training and supervising other laboratory personnel, who may refer sensitive or unusual situations to the incumbent. Problems that cannot be resolved by the incumbent will be referred to the most senior Lab personnel.Disclaimer This job description has been designed to indicate the general nature and level of work performed by employees within this classification.
It is not designed to contain or be interpreted as a comprehensive inventory of all duties, responsibilities and qualifications required of employees assigned to the job.
Comments Work Environment and Level of Frequency that may be required:Nearly Continuously:
Laboratory environment
Often:
Exposure to animals, and hazards (includes a variety of physical conditions, such as proximity to moving mechanical parts, moving vehicles, electrical current, working on scaffolding and high places, or exposure to chemicals)
Seldom:
Physical Requirements and Level of Frequency that may be required
Nearly Continuously:
Hearing, listening, talking
Often:
Repetitive hand motion (such as typing), walking, standing, sitting
Seldom:
Bending, reaching overhead.
Minimum Qualifications
Candidates should have a PhD, MD, or MD/PhD (or equivalent) degree or should be close to obtaining their doctoral or medical degree.
A working knowledge of advanced molecular biology, cell biology, and genomics techniques as well as the ability to make statistical calculations, analyze results, prepare reports and perform specialized tests also required.
Two letters of recommendation are required.The applicant must demonstrate proficiency in molecular biology techniques, including, but not limited to PCR , DNA cloning, and working with RNA .
Experience with animals is required. Experience with tissue culture is preferred, but not required. OSHA training and certification in animal care and use or the willingness to complete the certification will be required.IRB CITI Course in the Protection of Human Research subjects certificate obtained within two months of hire and demonstrated human relations and effective communication skills are also required.
Some departments may require IATA DGR training within two months.Applicants must demonstrate the potential ability to perform the essential functions of the job as outlined in the position description.
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