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- Develop bioreactor-based cell culture processes for manufacturing of AAV-based gene therapy vectors across multiple preclinical programs
- Execute PD experiments in shaken cultures and stirred-tank bioreactors from 2L-250L scale
- Optimize expression and harvest processes for improved consistency, performance, and product quality
- Support scaleup and process transfer to manufacturing groups; including scaledown experiments, and authorship of technical documents
- B.S. degree in biochemical engineering, cell biology, biochemistry, or related field and 2-6 years of experience in a process development or MSAT setting
- OR; Master's degree related to bioprocessing, with experience operating mammalian cell culture bioreactors and some industry experience
- Prior experience operating mammalian cell culture bioreactors is required, and impeccable sterile technique is expected. Experience with single-use bioreactors and/or vector production is desired, but not needed
- Ability to design scientifically sound experiments under guidance, to interpret results, and to present findings
Process Development Associate - South San Francisco, United States - Astrix
Description
We are seeking an Upstream Process Development Associate to join a growing gene therapy company out of South San Francisco. In this role you will collaborate to develope and optimize bioreactor-based cell culture processes for manufacturing AAV-based gene therapy vectors.
Responsibilities
Requirements