Principal CADD Scientist - San Diego - Genesis Molecular AI

    Genesis Molecular AI
    Genesis Molecular AI San Diego

    2 days ago

    Description

    Overview

    Genesis Molecular AI is assembling a world-class computational chemistry team to revolutionize drug discovery through cutting-edge machine learning and biophysical simulation. We are seeking a Principal CADD Scientist to join our team, working directly with scientists in our state-of-the-art wet lab and with our distributed computational chemistry and CADD science teams across the US.

    What You Will Do (Key Responsibilities)

    • Utilize a combination of industry-standard and proprietary AI-powered CADD tools to guide small molecule drug discovery programs across a diverse target portfolio, including novel targets with limited chemical precedents.
    • Use approaches like virtual screening, molecular simulation, and potency and ADMET prediction to support key decision-making in drug discovery efforts.
    • Collaborate closely with medicinal chemists in molecular design and the development of project-specific computational approaches.
    • Act as a cross-team connector, effectively communicating between our computational chemistry and medicinal chemistry teams to ensure seamless information flow and collaborative decision making.
    • Adapt to a fast-paced environment where innovation and quick iteration are encouraged.

    What You'll Bring (Qualifications)

    • PhD in Computational Chemistry, Structural Biology, or a related field. This particular role may also be suitable for PhD-level scientists with degrees in organic or medicinal chemistry with extensive experience in the lab, who have transitioned into industry roles in CADD.
    • Deep understanding of structure-based drug design and protein-ligand interactions.
    • Proficiency with industry-standard CADD tools such as MOE, PyMOL, and Schrodinger Suite.
    • Minimum of 5+ years of industry experience as a CADD scientist in pharma or biotech, with hands-on experience in active drug discovery programs.
    • Onsite in our San Diego lab is preferred for this role, to be able to collaborate with our scientists. We are open to remote team members too.

    What We Offer

    • Competitive Pay
    • Health Care Plans (including Medical, Dental, and Vision, fully covered for the employees)
    • Stock Option Eligibility
    • 401(k) Plan
    • Open PTO Policy
    • Paid Company Holidays
    • Subsidized lunch and snacks at our offices

    About Genesis Molecular AI

    Genesis Molecular AI is pioneering foundation models for molecular AI to unlock a new era of drug design and development. The company's generative and predictive AI platform, GEMS (Genesis Exploration of Molecular Space), integrates AI and physics into industry-leading models to generate and optimize drug molecules, including the breakthrough generative diffusion model Pearl for structure prediction. Genesis has raised over $300 million from leading AI, tech and life science-focused investors, signed multiple AI-focused research collaborations with major pharma partners, and is deploying GEMS to advance an internal therapeutics pipeline for a variety of high-impact targets.

    Genesis is headquartered in San Mateo, CA, with a fully integrated laboratory in San Diego. We are proud to be an inclusive workplace and an Equal Opportunity Employer.


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