- Develop method using LC-MS/MS platform for large molecules (Proteins, antibodies, ADC, Oligonucleotides, Liposomal drugs, biomarkers, etc) quantitation in biological matrices.
- Facilitate the method transfer from the Method development team with the method validation team.
- Communicate project timelines, status, and data to Principal Investigator effectively addressing any issues that may arise.
- Ability to work on multiple projects at the same time.
- Research literature and external sources and identify new techniques and procedures that strengthen Frontage's capabilities.
- Maintain the proper level of regulatory compliance. Ensure that GLP regulations and SOPs are followed in all bioanalytical service activities.
- Help with training and/or mentoring of junior scientific staff.
- Set-up, utilize, and maintain complex instrumentation Follow safety precautions.
- Ph.D. or Master's degree in Analytical Chemistry, Biochemistry, Biology or related scientific discipline.
- 6-10 years of direct experience of bioanalytical method development for large molecules using LC-MS/MS in the biotech, pharma or CRO industry.
- Demonstrated experience in mass-spectrometry method development for antibodies including LC-MS intact protein analysis, peptide mapping, conjugate analysis etc.
- Demonstrated experience in small molecule and protein mass-spectrometry of quantitation of antibody drug-conjugates (ADC), including total Antibody, Conjugated payload, and free payload.
- Experience with Oligonucleotides and liposomal drug quantitation using LC-MS/MS is a plus.
- Proven ability to successfully work in a team environment. Excellent oral and written communication skills.
- Good knowledge and application of GLP with the ability to train technical personnel.
- Efficient time management.
- Strong troubleshooting and analytical skills.
- Detail oriented and meticulous.
- Ability to work independently under time constraints.
-
Scientist/Senior Scientist
1 day ago
Frontage Lab Exton, United StatesScientist/Senior Scientist · Full-Time · Exton PA · Frontage Laboratories · Frontage Laboratories is a CRO / Clinical Research Organization providing integrated, science-driven, product development services throughout the drug discovery and development process to enable life scie ...
-
Scientist/Senior Scientist
2 days ago
Frontage Laboratories Exton, United StatesJob Description · Job DescriptionScientist/Senior Scientist - Cell Bioassay/Potency · Title: Scientist/Sr. Scientist, Cell Bioassay/Potency · Location: 760 Pennsylvania Drive, Exton, PA 19341 · Reports to: Sr Director BGC Therapy Operations · Full-time · Frontage Laboratories In ...
-
Scientist/Senior Scientist
2 days ago
Frontage Laboratories Exton, United StatesJob Description · Job DescriptionScientist/Senior Scientist · Full-Time · Exton PA · Frontage Laboratories · Frontage Laboratories is a CRO / Clinical Research Organization providing integrated, science-driven, product development services throughout the drug discovery and devel ...
-
Senior Scientist
2 days ago
Frontage Laboratories Exton, United StatesJob Description · Job DescriptionSenior Method development scientist-Biomarker LC-MS/MS · Title: Senior method development scientist- Biomarker LC-MS/MS · Location: 700 Pennsylvania Dr. Exton, PA · Reports to: SVP, Central Lab, Biomarker, and Biologics Services · Full-time/on-sit ...
-
Scientist/ Senior Scientist-Genomics
2 days ago
Frontage Laboratories Exton, United StatesJob Description · Job DescriptionSenior Scientists and Scientists - Genomics · Full Time · Location-Exton, PA · Frontage Laboratories Inc. (Frontage), is a global contract research organization with broad expertise in supporting pre-clinical and clinical drug development. Frontag ...
-
Frontage Lab Exton, United StatesScientist/Senior Scientist - Pharmaceutical Analysis - Large Molecule · Exton, PA (Research) · Roles and Responsibilities: · * Develop and apply biochemistry, biophysics methods, immunoassays, and other state of the art analytical technologies to analyze and characterize oligonuc ...
-
Senior Scientist-Biomarker
1 day ago
Frontage Lab Exton, United StatesFrontage Laboratories: · Frontage Laboratories Inc. (Frontage), is a global contract research organization with broad expertise in supporting pre-clinical and clinical drug development. Frontage operates out of several different locations within the USA, Canada, and China. Fronta ...
-
Frontage Laboratories Exton, United StatesJob Description · Job DescriptionScientist/Senior Scientist - Pharmaceutical Analysis - Large MoleculeExton, PA (Research) · Roles and Responsibilities: · Develop and apply biochemistry, biophysics methods, immunoassays, and other state of the art analytical technologies to analy ...
-
Senior Scientist- Biologics
1 day ago
Frontage Lab Exton, United StatesSenior Scientist - Biologics · Full Time · Exton PA · Frontage Laboratories · Frontage Laboratories is a CRO / Clinical Research Organization providing integrated, science-driven, product development services throughout the drug discovery and development process to enable life sc ...
-
Senior Scientist-Biomarker
2 days ago
Frontage Laboratories Exton, United StatesJob Description · Job DescriptionFrontage Laboratories: · Frontage Laboratories Inc. (Frontage), is a global contract research organization with broad expertise in supporting pre-clinical and clinical drug development. Frontage operates out of several different locations within t ...
-
Senior Scientist- Biologics
2 days ago
Frontage Laboratories Exton, United StatesJob Description · Job DescriptionSenior Scientist - Biologics · Full Time · Exton PA · Frontage Laboratories · Frontage Laboratories is a CRO / Clinical Research Organization providing integrated, science-driven, product development services throughout the drug discovery and deve ...
-
Senior QC Scientist
6 days ago
Beacon Hill Exton, United Stateseneral Responsibilities: · Performs testing in support of product manufacturing, employing manual and automated analytical equipment for a variety of molecular, protein and cell based assays, such as PCR, ELISA, and flow cytometry. · Responsibilities: · Execute Analytical Test Me ...
-
Immunome Inc Exton, United StatesJob title: Senior Research Scientist, Antibody Engineering · Location: Exton, PA · Reports To: Senior Director, Antibody Engineering · About Us: · Immunome is a biotechnology company dedicated to developing first-in-class and best-in-class targeted cancer therapies. Our portfoli ...
-
Senior Data Scientist
1 week ago
CubeSmart Malvern, United StatesCubeSmart is seeking a Senior Data Scientist to join our dynamic Revenue Management team at our Malvern, PA headquarters. We're seeking someone who is passionate about using data to drive strategic decisions and optimize our business operations. · ...
-
Senior Data Scientist
1 week ago
New York Technology Partners Malvern, United StatesTitle: Senior Data Scientist · Location: Malvern, PA (Hybrid) · Duration: long term contract · Job Description · Machine Learning techniques and algorithms · Python, R · SQL, NoSQL · Spark · Tableau, Jupiter Notebooks · Nice to have is AWS: Sagemaker, Lambda, EMR, Glue · ...
-
Frontage Laboratories Exton, United StatesSenior Scientist/ Principal Investigator, Bioanalytical Services · Exton, PA (Corporate) · ResponsibilitiesValidate unique scientific methods, assays, techniques, reports, etc. Run sensitive, reliable and efficient LC-MS/MS bioanalytical assays for TK/PK assessment · Perform high ...
-
Senior Data Scientist
2 weeks ago
New York Technology Partners Malvern, United Statesob Description: · We are seeking a highly skilled and experienced Data Scientist to join our team. As a Data Scientist, you will be responsible for leveraging advanced analytics and machine learning techniques to extract insights from complex datasets and drive data-driven decisi ...
-
Senior Data Scientist
2 weeks ago
Vanguard Malvern, United StatesLeads and executes deep dive diagnostic, predictive, and prescriptive analytics to support data-driven business decision making. Mentors and develops junior data scientists and analysts. · Your Challenge: · As a Data Scientist / Artificial Intelligence / Machine Learning / AI/M ...
-
Frontage Laboratories Exton, United StatesJob Description · Job DescriptionSenior Scientist/ Principal Investigator, Bioanalytical ServicesExton, PA (Corporate) · ResponsibilitiesValidate unique scientific methods, assays, techniques, reports, etc. Run sensitive, reliable and efficient LC-MS/MS bioanalytical assays for T ...
-
Frontage Laboratories Exton, United StatesJob Description · Job DescriptionTitle: Senior method development scientist-Large Molecule Bioanalysis by LC-MS/MS · Location: 700 Pennsylvania Dr. Exton, PA · Reports to: Executive Director, Bioanalytical Services · Full-time/on-site · Frontage Laboratories Inc. is an award winn ...
Senior Scientist - Exton, United States - Frontage Laboratories
Description
Senior Method development scientist-Biomarker LC-MS/MSTitle: Senior method development scientist- Biomarker LC-MS/MS
Location: 700 Pennsylvania Dr. Exton, PA
Reports to: SVP, Central Lab, Biomarker, and Biologics Services
Full-time/on-site
Frontage Laboratories Inc. is an award winning, publicly listed (HKSE), full-service CRO/Contract Research Organization operating over 25 state-of-the-art laboratories across the US, Canada and China, and growing over 30% YOY. Our core competencies include drug metabolism, pharmacokinetics/ pharmacodynamics (PK/PD), safety and toxicology, bioanalytical services, chemistry and manufacturing controls for drug development, and core laboratory services for clinical trials.
Position/Job Summary:
The Senior method development scientist supports method development using LC-MS/MS platform for large molecules (biomarkers, proteins, antibodies, ADCs, Oligonucleotides, etc). The senior method development scientist will be a member of the method development team, the responsibility includes serving as subject matter expert when new proposal is received, reviewing the client request and evaluating the feasibility of the project, developing the method after the contract is signed, transferring the developed method to the validation team, and troubleshooting for challenging method.
Roles & Responsibilities:
