Scientist I - San Francisco, United States - Deciduous Therapeutics

Description

Scientist I – Immunology

Deciduous Therapeutics is an early stage, venture backed biotechnology company based in San Francisco, CA. Our mission is to develop novel drugs that activate the endogenous immune system to eliminate senescent cells for the treatment of age-related diseases in the fibrosis and metabolic therapeutic areas.

We are looking for a highly ambitious Scientist I to join our team on location in San Francisco. This is an opportunity to make a significant impact on the trajectory and success of the company. This will be a highly cross-functional role across Research and Operations, reporting directly to a Senior Research Scientist.

Excited candidates, please review our founding publication in Cell Press Medicine and a short video that summarized the publication.

About the position

We are seeking an exceptional Scientist with 2+ years of industry experience to join our growing team. You will be responsible for conducting scientific research and experiments related to immune cell activation and evaluation of novel immune stimulants using in vivo and in vitro modeling. Your day-to-day tasks will include designing and performing experiments, analyzing data, and contributing to the development of therapeutic strategies. You will collaborate with interdisciplinary teams and contribute to the advancement of therapeutics in the field of age-related diseases.

Education Minimum Requirements

· PhD in immunology, cell biology, or related biomedical science with 2+ years of industry experience.

· MS in immunology, cell biology, or related biomedical science with 3-5 years of industry experience.

Key Responsibilities

· Design and execute high-dimensional flow-based assays to screen and validate Deciduous' lead compounds.

· Develop and perform immunological cell-based functional assays (cell lines, primary cells, whole blood) to support target validation, and drug target pathway activity.

· Collect, process, and critically interpret data; Accurately document assay results and analyze data through the maintenance of an updated electronic laboratory notebook, prepare study reports, and communicate results and research progress in lab meetings as needed.

Required Experience and Skills

· Masters with 3-5 years of industry experience OR PhD with 1-3 years of industry experience.

· Strong background in immunology, particularly T-cell biology, innate immune system, or related expertise.

· Demonstrate track record of productivity with running and analyzing multi-color (8+ colors) flow cytometry, immune cell phenotyping, T cell and NKT cell stimulation assays, cytotoxic assays, ELISA, and cell culture aseptic technique.

· Well-developed understanding of flow cytometry, cell sorting and immunology, following best industry practices.

· Experience working with mouse and human samples, developing, and optimizing cell-based immunological assays to assess immune responses from PBMCs and various immune cell subsets.

· Proficiency in flow cytometry analysis and acquisition software, Flowjo and GraphPad Prism.

· Excellent analytical, problem-solving skills, and project management skills, with meticulous attention to detail.

· Commitment to scientific rigor.

· The ideal candidate is entrepreneurial, energetic, and excited to work in a fast paced, and dynamic environment.

· Sponsorship may be possible.

Compensation

We offer a competitive salary and stock options commensurate to experience, and health benefits. In addition, we provide a monthly activity stipend to support outside personal interests.

Furthermore, we are a company that strongly believes in fostering the intellectual advancement of our team. As such, in addition to providing individualized professional mentorship we will support you in external educational opportunities (online courses, seminars, conferences) that intersect with areas of interest for the company.

Deciduous is an equal opportunity employer. We value diversity of personal identity, experience, and thought. We will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, age, protected veteran status, or disability status.

To apply, please send your C.V. along with a brief cover letter to